Skip to main content
Erschienen in: Pediatric Cardiology 8/2016

24.08.2016 | Original Article

Doppler Flow Pattern and Arterial Stiffness in Patients with Aortic Coarctation

verfasst von: Susana Cordeiro, João Gomes, Inês Carmo Mendes, Duarte Saraiva Martins, Ana Sousa, Rui Anjos

Erschienen in: Pediatric Cardiology | Ausgabe 8/2016

Einloggen, um Zugang zu erhalten

Abstract

Patients with aortic coarctation (CoAo) often have a diastolic flow in the descending aorta. The effect of arterial stiffness on CoAo flow pattern was described in vitro and with computer models. Study of Doppler flow patterns and arterial stiffness may provide helpful data to support the decision of CoAo treatment. Fifty studies were obtained in 31 patients (14 women, 21.5 ± 15.5 years). In 19 patients, studies were performed before and after percutaneous intervention. Systolic invasive gradients were measured (Sgrad). Doppler parameters included Doppler corrected gradient (Dgrad), diastolic velocity at end of T wave (DVT), end diastolic velocity (DVQ), systolic and diastolic half pressure times (SHPTc and DHPTc) and velocity runoff (VRc). In 19 patients, before intervention, arterial stiffness was assessed by measuring pulsed wave velocity (PWV) between right carotid and radial arteries. Sgrad showed correlation with Dgrad, DVT, DVQ, SHPTc, DHPTc and VRc (p < 0.01). Using multiple regression models, Sgrad variability was best explained by combining the variables Dgrad and DHPTc (R 2 = 0.766). A variable named DTail was obtained with DTail = 1 if DHPTc > 0. In the group with Sgrad below 30 mmHg, a negative correlation was found between DTail and PWV (p = 0.024), suggesting that low aortic stiffness contributes to persistent diastolic flow in the descending aorta. Doppler systolic and diastolic parameters correlated well with severity of CoAo. In mild to moderate CoAo, Doppler diastolic flow in the descending aorta was more likely in patients with lower arterial stiffness.
Literatur
1.
Zurück zum Zitat Lai W, Mertens L, Cohen M, Geva T (2009) Echocardiography in pediatric and congenital heart disease from fetus to adult. Wiley, ChichesterCrossRef Lai W, Mertens L, Cohen M, Geva T (2009) Echocardiography in pediatric and congenital heart disease from fetus to adult. Wiley, ChichesterCrossRef
2.
Zurück zum Zitat Aldousany AW, DiSessa TG, Alpert BS, Birnbaum SE, Willey ES (1990) Significance of the Doppler-derived gradient across a residual aortic coarctation. Pediatr Cardiol 11:8–14CrossRefPubMed Aldousany AW, DiSessa TG, Alpert BS, Birnbaum SE, Willey ES (1990) Significance of the Doppler-derived gradient across a residual aortic coarctation. Pediatr Cardiol 11:8–14CrossRefPubMed
3.
Zurück zum Zitat Carvalho J, Redington AN, Shinebourne EA, Rigby ML, Gibson D (1990) Continuous wave Doppler echocardiography and coarctation of the aorta: gradients and flow patterns in the assessment of severity. Br Heart J 64:133–137CrossRefPubMedPubMedCentral Carvalho J, Redington AN, Shinebourne EA, Rigby ML, Gibson D (1990) Continuous wave Doppler echocardiography and coarctation of the aorta: gradients and flow patterns in the assessment of severity. Br Heart J 64:133–137CrossRefPubMedPubMedCentral
4.
Zurück zum Zitat Tan JL, Babu-Narayan SV, Henein MY, Mullen M, Li W (2005) Doppler echocardiographic profile and indexes in the evaluation of aortic coarctation in patients before and after stenting. J Am Coll Cardiol 46:1045–1053CrossRefPubMed Tan JL, Babu-Narayan SV, Henein MY, Mullen M, Li W (2005) Doppler echocardiographic profile and indexes in the evaluation of aortic coarctation in patients before and after stenting. J Am Coll Cardiol 46:1045–1053CrossRefPubMed
5.
Zurück zum Zitat Tacy TA, Baba K, Cape EG (1999) Effect of aortic compliance on Doppler diastolic flow pattern in coarctation of the aorta. J Am Soc Echocardiogr 12:636–642CrossRefPubMed Tacy TA, Baba K, Cape EG (1999) Effect of aortic compliance on Doppler diastolic flow pattern in coarctation of the aorta. J Am Soc Echocardiogr 12:636–642CrossRefPubMed
6.
Zurück zum Zitat Degroff CG, Orlando W, Shandas R (2003) Insights into the effect of aortic compliance on Doppler diastolic flow patterns seen in coarctation of the aorta: a numeric study. J Am Soc Echocardiogr 16:162–169CrossRefPubMed Degroff CG, Orlando W, Shandas R (2003) Insights into the effect of aortic compliance on Doppler diastolic flow patterns seen in coarctation of the aorta: a numeric study. J Am Soc Echocardiogr 16:162–169CrossRefPubMed
7.
Zurück zum Zitat Laurent S, Cockcroft J, Van Bortel L et al (2006) Expert consensus document on arterial stiffness: methodological issues and clinical applications. Eur Heart J. doi:10.1093/eurheartj/ehl254 Laurent S, Cockcroft J, Van Bortel L et al (2006) Expert consensus document on arterial stiffness: methodological issues and clinical applications. Eur Heart J. doi:10.​1093/​eurheartj/​ehl254
8.
Zurück zum Zitat Castellanos L, Melendez G, Meave A, Soto M, Magaña J (2015) Aortic wall abnormalities in patients with aortic coarctation. J Cardiovasc Magn Reson 17:P204CrossRef Castellanos L, Melendez G, Meave A, Soto M, Magaña J (2015) Aortic wall abnormalities in patients with aortic coarctation. J Cardiovasc Magn Reson 17:P204CrossRef
Metadaten
Titel
Doppler Flow Pattern and Arterial Stiffness in Patients with Aortic Coarctation
verfasst von
Susana Cordeiro
João Gomes
Inês Carmo Mendes
Duarte Saraiva Martins
Ana Sousa
Rui Anjos
Publikationsdatum
24.08.2016
Verlag
Springer US
Erschienen in
Pediatric Cardiology / Ausgabe 8/2016
Print ISSN: 0172-0643
Elektronische ISSN: 1432-1971
DOI
https://doi.org/10.1007/s00246-016-1458-8

Weitere Artikel der Ausgabe 8/2016

Pediatric Cardiology 8/2016 Zur Ausgabe

Update Kardiologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.