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Pediatric Nephrology

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23.06.2016 | Educational Review

Drug-associated acute kidney injury: who’s at risk?

verfasst von: Emily L. Joyce, Sandra L. Kane-Gill, Dana Y. Fuhrman, John A. Kellum

Erschienen in: Pediatric Nephrology | Ausgabe 1/2017

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Abstract

The contribution of nephrotoxic medications to the development of acute kidney injury (AKI) is becoming better understood concomitant with the increased incidence of AKI in children. Treatment of AKI is not yet available, so prevention continues to be the most effective approach. There is an opportunity to mitigate severity and prevent the occurrence of AKI if children at increased risk are identified early and nephrotoxins are used judiciously. Early detection of AKI is limited by the dependence of nephrologists on serum creatinine as an indicator. Promising new biomarkers may offer early detection of AKI prior to the rise in serum creatinine. Early detection of evolving AKI is improving and offers opportunities for better management of nephrotoxins. However, the identification of patients at increased risk will remain an important first step, with a focus on the use of biomarker testing and interpretation of the results.

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Titel: Drug-associated acute kidney injury: who’s at risk?
verfasst von: Emily L. Joyce
Sandra L. Kane-Gill
Dana Y. Fuhrman
John A. Kellum
Publikationsdatum: 23.06.2016
Verlag: Springer Berlin Heidelberg
Erschienen in: Pediatric Nephrology / Ausgabe 1/2017
Print ISSN: 0931-041X
Elektronische ISSN: 1432-198X
DOI: https://doi.org/10.1007/s00467-016-3446-x

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Drug-associated acute kidney injury: who’s at risk?

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