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Current Allergy and Asthma Reports

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01.06.2021 | Anaphylaxis and Drug Allergy (BT Kelly and M Castells, Section Editors)

Drug Desensitizations for Chemotherapy: Safety and Efficacy in Preventing Anaphylaxis

verfasst von: Joana Caiado, Mariana C. Castells

Erschienen in: Current Allergy and Asthma Reports | Ausgabe 6/2021

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Abstract

Hypersensitivity reactions (HSRs) to antineoplastic drugs are increasing due to the expanding use of classical and new drugs in a wide variety of malignancies.

Purpose of Review

The goal of this review is to provide current best practices in the diagnosis and management of HSRs based on data and evidence.

Recent Findings

A plethora of studies have provided evidence of the safety and efficacy of rapid drug desensitizations (RDD) to allow for the reintroduction of antineoplastic drugs following an HSR, based on risk stratification. Recently described biomarkers such as basophil activation test, total IgE, BRCA genotyping, and serum IL-6 can aid in guiding improved precision desensitization protocols. Personalized premedication regimens and protocols have improved RDD safety and outcomes.

Summary

RDD allows for the continued use of chemotherapeutic drugs without impaired drug efficacy. RDD represents the best approach to maintain cancer patients on their most effective treatments.

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Titel: Drug Desensitizations for Chemotherapy: Safety and Efficacy in Preventing Anaphylaxis
verfasst von: Joana Caiado
Mariana C. Castells
Publikationsdatum: 01.06.2021
Verlag: Springer US
Erschienen in: Current Allergy and Asthma Reports / Ausgabe 6/2021
Print ISSN: 1529-7322
Elektronische ISSN: 1534-6315
DOI: https://doi.org/10.1007/s11882-021-01014-x

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Springer Medizin

Drug Desensitizations for Chemotherapy: Safety and Efficacy in Preventing Anaphylaxis

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Springer Medizin

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Recent Findings

Summary

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Neu im Fachgebiet HNO

HNO-Op. auch mit über 90?

Intrakapsuläre Tonsillektomie gewinnt an Boden

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„Nur wer sich gut aufgehoben fühlt, kann auch für Patientensicherheit sorgen“

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