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Erschienen in: European Journal of Clinical Microbiology & Infectious Diseases 7/2017

16.02.2017 | Review

Drug-resistant Neisseria gonorrhoeae: latest developments

verfasst von: B. Suay-García, M. T. Pérez-Gracia

Erschienen in: European Journal of Clinical Microbiology & Infectious Diseases | Ausgabe 7/2017

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Abstract

Gonorrhea is the second most frequently reported notifiable disease in the United States and is becoming increasingly common in Europe. The purpose of this review was to assess the current state of drug-resistant Neisseria gonorrhoeae in order to evaluate future prospects for its treatment. An exhaustive literature search was conducted to include the latest research regarding drug resistance and treatment guidelines for gonorrhea. Gonococci have acquired all known resistance mechanisms to all antimicrobials used for treatment. Currently, the European Union, the United States, and the United Kingdom have established surveillance programs to assess, on a yearly basis, the development of gonococcal resistance. Current treatment guidelines are being threatened by the increasing number of ceftriaxone-, cefixime-, and azithromycin-resistant N. gonorrhoeae strains being detected worldwide. This has led the scientific community to develop new treatment options with new molecules in order to persevere in the battle against this “superbug”.
Literatur
1.
Zurück zum Zitat World Health Organization (WHO), Department of Reproductive Health and Research (2012) Global action plan to control the spread and impact of antimicrobial resistance in Neisseria gonorrhoeae. 36 pp World Health Organization (WHO), Department of Reproductive Health and Research (2012) Global action plan to control the spread and impact of antimicrobial resistance in Neisseria gonorrhoeae. 36 pp
3.
Zurück zum Zitat Centers for Disease Control and Prevention (CDC) (2012) Cephalosporin-resistant Neisseria gonorrhoeae public health response plan. 43 pp Centers for Disease Control and Prevention (CDC) (2012) Cephalosporin-resistant Neisseria gonorrhoeae public health response plan. 43 pp
4.
Zurück zum Zitat Bodoev IN, Il’ina EN (2015) Molecular mechanisms of drug resistance Neisseria gonorrhoeae: history and prospects. Mol Gen Mikrobiol Virusol 33(3):22–27PubMed Bodoev IN, Il’ina EN (2015) Molecular mechanisms of drug resistance Neisseria gonorrhoeae: history and prospects. Mol Gen Mikrobiol Virusol 33(3):22–27PubMed
6.
Zurück zum Zitat Fermer C, Kristiansen BE, Sköld O et al (1995) Sulfonamide resistance in Neisseria meningitidis as defined by site-directed mutagenesis could have its origin in other species. J Bacteriol 177(16):4669–4675CrossRefPubMedPubMedCentral Fermer C, Kristiansen BE, Sköld O et al (1995) Sulfonamide resistance in Neisseria meningitidis as defined by site-directed mutagenesis could have its origin in other species. J Bacteriol 177(16):4669–4675CrossRefPubMedPubMedCentral
7.
Zurück zum Zitat Tribuddharat C, Pongpech P, Charoenwatanachokchai A et al (2016) Gonococcal antimicrobial susceptibility and prevalence of bla TEM-1, bla TEM-135 genes in Thailand. Jpn J Infect Dis Tribuddharat C, Pongpech P, Charoenwatanachokchai A et al (2016) Gonococcal antimicrobial susceptibility and prevalence of bla TEM-1, bla TEM-135 genes in Thailand. Jpn J Infect Dis
8.
Zurück zum Zitat Ropp PA, Hu M, Olesky M et al (2002) Mutations in ponA, the gene encoding penicillin-binding protein 1, and a novel locus, penC, are required for high-level chromosomally mediated penicillin resistance in Neisseria gonorrhoeae. Antimicrob Agents Chemother 46:769–777CrossRefPubMedPubMedCentral Ropp PA, Hu M, Olesky M et al (2002) Mutations in ponA, the gene encoding penicillin-binding protein 1, and a novel locus, penC, are required for high-level chromosomally mediated penicillin resistance in Neisseria gonorrhoeae. Antimicrob Agents Chemother 46:769–777CrossRefPubMedPubMedCentral
10.
Zurück zum Zitat Serra-Pladevall J, Barberá MJ, Rodriguez S et al (2016) Neisseria gonorrhoeae antimicrobial susceptibility in Barcelona: penA, ponA, mtrR, and porB mutations and NG-MAST sequence types associated with decreased susceptibility to cephalosporins. Eur J Clin Microbiol Infect Dis 35(9):1549–1556. doi:10.1007/s10096-016-2696-7 CrossRefPubMed Serra-Pladevall J, Barberá MJ, Rodriguez S et al (2016) Neisseria gonorrhoeae antimicrobial susceptibility in Barcelona: penA, ponA, mtrR, and porB mutations and NG-MAST sequence types associated with decreased susceptibility to cephalosporins. Eur J Clin Microbiol Infect Dis 35(9):1549–1556. doi:10.​1007/​s10096-016-2696-7 CrossRefPubMed
11.
Zurück zum Zitat Morse SA, Johnson SR, Biddle JW et al (1986) High-level tetracycline resistance in Neisseria gonorrhoeae is result of acquisition of streptococcal tetM determinant. Antimicrob Agents Chemother 30:664–670CrossRefPubMedPubMedCentral Morse SA, Johnson SR, Biddle JW et al (1986) High-level tetracycline resistance in Neisseria gonorrhoeae is result of acquisition of streptococcal tetM determinant. Antimicrob Agents Chemother 30:664–670CrossRefPubMedPubMedCentral
12.
Zurück zum Zitat Phillips I (1976) Beta-lactamase-producing, penicillin-resistant gonococcus. Lancet 2:656–657CrossRefPubMed Phillips I (1976) Beta-lactamase-producing, penicillin-resistant gonococcus. Lancet 2:656–657CrossRefPubMed
13.
Zurück zum Zitat Davies C, Bussiere DE, Golden BL et al (1998) Ribosomal proteins S5 and L6: high-resolution crystal structures and roles in protein synthesis and antibiotic resistance. J Mol Biol 279:873–888CrossRefPubMed Davies C, Bussiere DE, Golden BL et al (1998) Ribosomal proteins S5 and L6: high-resolution crystal structures and roles in protein synthesis and antibiotic resistance. J Mol Biol 279:873–888CrossRefPubMed
15.
Zurück zum Zitat Belland RJ, Morrison SG, Ison C et al (1994) Neisseria gonorrhoeae acquires mutations in analogous regions of gyrA and parC in fluoroquinolone-resistant isolates. Mol Microbiol 14:371–380CrossRefPubMed Belland RJ, Morrison SG, Ison C et al (1994) Neisseria gonorrhoeae acquires mutations in analogous regions of gyrA and parC in fluoroquinolone-resistant isolates. Mol Microbiol 14:371–380CrossRefPubMed
17.
Zurück zum Zitat Roberts MC, Chung WO, Roe D et al (1999) Erythromycin-resistant Neisseria gonorrhoeae and oral commensal Neisseria spp. carry known rRNA methylase genes. Antimicrob Agents Chemother 43:1367–1372PubMedPubMedCentral Roberts MC, Chung WO, Roe D et al (1999) Erythromycin-resistant Neisseria gonorrhoeae and oral commensal Neisseria spp. carry known rRNA methylase genes. Antimicrob Agents Chemother 43:1367–1372PubMedPubMedCentral
18.
19.
Zurück zum Zitat Morse SA, Johnson SR, Biddle JW et al (1986) High-level tetracycline resistance in Neisseria gonorrhoeae is result of acquisition of streptococcal tetM determinant. Antimicrob Agents Chemother 30:664–670CrossRefPubMedPubMedCentral Morse SA, Johnson SR, Biddle JW et al (1986) High-level tetracycline resistance in Neisseria gonorrhoeae is result of acquisition of streptococcal tetM determinant. Antimicrob Agents Chemother 30:664–670CrossRefPubMedPubMedCentral
21.
Zurück zum Zitat Ohnishi M, Golparian D, Shimuta K et al (2011) Is Neisseria gonorrhoeae initiating a future era of untreatable gonorrhea?: detailed characterization of the first strain with high-level resistance to ceftriaxone. Antimicrob Agents Chemother 55:3538–3545. doi:10.1128/AAC.00325-11 CrossRefPubMedPubMedCentral Ohnishi M, Golparian D, Shimuta K et al (2011) Is Neisseria gonorrhoeae initiating a future era of untreatable gonorrhea?: detailed characterization of the first strain with high-level resistance to ceftriaxone. Antimicrob Agents Chemother 55:3538–3545. doi:10.​1128/​AAC.​00325-11 CrossRefPubMedPubMedCentral
22.
Zurück zum Zitat Unemo M, Golparian D, Nicholas R et al (2012) High-level cefixime- and ceftriaxone-resistant Neisseria gonorrhoeae in France: novel penA mosaic allele in a successful international clone causes treatment failure. Antimicrob Agents Chemother 56:1273–1280. doi:10.1128/AAC.05760-11 CrossRefPubMedPubMedCentral Unemo M, Golparian D, Nicholas R et al (2012) High-level cefixime- and ceftriaxone-resistant Neisseria gonorrhoeae in France: novel penA mosaic allele in a successful international clone causes treatment failure. Antimicrob Agents Chemother 56:1273–1280. doi:10.​1128/​AAC.​05760-11 CrossRefPubMedPubMedCentral
29.
Zurück zum Zitat Japanese Society of Sexually Transmitted Infection (2011) Gonococcal infection. Sexually transmitted infections, diagnosis and treatment guidelines 2011. Jpn Sex Transm Dis 22(Suppl 1):52–59 Japanese Society of Sexually Transmitted Infection (2011) Gonococcal infection. Sexually transmitted infections, diagnosis and treatment guidelines 2011. Jpn Sex Transm Dis 22(Suppl 1):52–59
30.
Zurück zum Zitat Workowski KA, Bolan GA (2015) Sexually transmitted diseases treatment guidelines, 2015. MMWR Recomm Rep 64:1–137CrossRefPubMed Workowski KA, Bolan GA (2015) Sexually transmitted diseases treatment guidelines, 2015. MMWR Recomm Rep 64:1–137CrossRefPubMed
36.
Zurück zum Zitat Roberts MC, Remy JM, Longcor JD et al (2013) In vitro activity of delafloxacin against Neisseria gonorrhoeae clinical isolates. In: Proceedings of the STI & AIDS World Congress, Vienna, Austria, July 2013 Roberts MC, Remy JM, Longcor JD et al (2013) In vitro activity of delafloxacin against Neisseria gonorrhoeae clinical isolates. In: Proceedings of the STI & AIDS World Congress, Vienna, Austria, July 2013
37.
39.
Zurück zum Zitat Kerstein K, Fyfe C, Sutcliffe JA et al (2013) Eravacycline (TP-434) is active against susceptible and multidrug-resistant Neisseria gonorrhoeae. In: Proceedings of the 53rd Annual Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), Denver, Colorado, USA, 10–13 September 2013. Poster E-1181 Kerstein K, Fyfe C, Sutcliffe JA et al (2013) Eravacycline (TP-434) is active against susceptible and multidrug-resistant Neisseria gonorrhoeae. In: Proceedings of the 53rd Annual Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), Denver, Colorado, USA, 10–13 September 2013. Poster E-1181
40.
Zurück zum Zitat Zhang YY, Zhou L, Zhu DM et al (2004) In vitro activities of tigecycline against clinical isolates from Shanghai, China. Diagn Microbiol Infect Dis 50:267–281CrossRefPubMed Zhang YY, Zhou L, Zhu DM et al (2004) In vitro activities of tigecycline against clinical isolates from Shanghai, China. Diagn Microbiol Infect Dis 50:267–281CrossRefPubMed
41.
Zurück zum Zitat Fujimoto K, Takemoto K, Hatano K et al (2013) Novel carbapenem antibiotics for parenteral and oral applications: in vitro and in vivo activities of 2-aryl carbapenems and their pharmacokinetics in laboratory animals. Antimicrob Agents Chemother 57:697–707. doi:10.1128/AAC.01051-12 CrossRefPubMedPubMedCentral Fujimoto K, Takemoto K, Hatano K et al (2013) Novel carbapenem antibiotics for parenteral and oral applications: in vitro and in vivo activities of 2-aryl carbapenems and their pharmacokinetics in laboratory animals. Antimicrob Agents Chemother 57:697–707. doi:10.​1128/​AAC.​01051-12 CrossRefPubMedPubMedCentral
42.
Zurück zum Zitat Jacobsson S, Golparian D, Phan LT et al (2015) In vitro activities of the novel bicyclolides modithromycin (EDP-420, EP-013420, S-013420) and EDP-322 against MDR clinical Neisseria gonorrhoeae isolates and international reference strains. J Antimicrob Chemother 70:173–177. doi:10.1093/jac/dku344 CrossRefPubMed Jacobsson S, Golparian D, Phan LT et al (2015) In vitro activities of the novel bicyclolides modithromycin (EDP-420, EP-013420, S-013420) and EDP-322 against MDR clinical Neisseria gonorrhoeae isolates and international reference strains. J Antimicrob Chemother 70:173–177. doi:10.​1093/​jac/​dku344 CrossRefPubMed
43.
Zurück zum Zitat Golparian D, Fernandes P, Ohnishi M et al (2012) In vitro activity of the new fluoroketolide solithromycin (CEM-101) against a large collection of clinical Neisseria gonorrhoeae isolates and international reference strains, including those with high-level antimicrobial resistance: potential treatment option for gonorrhea? Antimicrob Agents Chemother 56:2739–2742. doi:10.1128/AAC.00036-12 CrossRefPubMedPubMedCentral Golparian D, Fernandes P, Ohnishi M et al (2012) In vitro activity of the new fluoroketolide solithromycin (CEM-101) against a large collection of clinical Neisseria gonorrhoeae isolates and international reference strains, including those with high-level antimicrobial resistance: potential treatment option for gonorrhea? Antimicrob Agents Chemother 56:2739–2742. doi:10.​1128/​AAC.​00036-12 CrossRefPubMedPubMedCentral
44.
Zurück zum Zitat Koeth LM, Difranco-Fisher J (2013) In vitro activity of dalbavancin against Neisseria gonorrhoeae and development of a broth microdilution method. In: Proceedings of IDWeek 2013, San Francisco, California, USA, 2–6 October 2013. Poster 255 Koeth LM, Difranco-Fisher J (2013) In vitro activity of dalbavancin against Neisseria gonorrhoeae and development of a broth microdilution method. In: Proceedings of IDWeek 2013, San Francisco, California, USA, 2–6 October 2013. Poster 255
Metadaten
Titel
Drug-resistant Neisseria gonorrhoeae: latest developments
verfasst von
B. Suay-García
M. T. Pérez-Gracia
Publikationsdatum
16.02.2017
Verlag
Springer Berlin Heidelberg
Erschienen in
European Journal of Clinical Microbiology & Infectious Diseases / Ausgabe 7/2017
Print ISSN: 0934-9723
Elektronische ISSN: 1435-4373
DOI
https://doi.org/10.1007/s10096-017-2931-x

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