Introduction
Methods
Ethics approval statement
Study patients
DECT imaging evaluation
Statistical analysis
Results
The MSU deposition of the painful joint
MSU locations | Gout group | Control group | |||||
---|---|---|---|---|---|---|---|
MSU positive (n = 110) | MSU negative (n = 26) | Positive rate (%) | MSU positive (n = 10) | MSU negative (n = 75) | Positive rate (%) | ||
Lower limb | Foot | 68 | 12 | 85.00 | 0 | 0 | 0 |
Knee | 18 | 4 | 81.81 | 0 | 5 | 0 | |
Ankle | 20 | 4 | 83.33 | 10 | 25 | 28.57 | |
Upper limb | Hand | 8 | 2 | 80.00 | 0 | 20 | 0 |
Wrist | 2 | 4 | 33.33 | 0 | 20 | 0 | |
Elbow | 2 | 0 | 100 | 0 | 5 | 0 | |
Shoulder | 2 | 0 | 100 | 0 | 0 | 0 |
Sensitivity and specificity of DECT detection of MSU crystal deposition for the diagnosis of gout with different disease durations
Group | Positive
n
| Negative
n
| Sensitivity % (95% CI) | Specificity % (95% CI) | Positive predictive value % (95% CI) | Negative predictive value % (95% CI) | Diagnostic accuracy % (95% CI) |
---|---|---|---|---|---|---|---|
First onset | 10 | 18 | 35.71 (20.71, 54.17) | 88.24 (79.68, 93.48) | 50.00 (29.93, 70.07) | 80.65 (71.47, 87.39) | 75.22 (66.52, 82.26) |
Less than 24 months | 32 | 20 | 61.54 (47.96, 73.53) | 88.24 (79.68, 93.48) | 76.19 (61.47, 86.52) | 78.95 (69.71, 85.94) | 78.1 (70.46, 84.21) |
More than 24 months | 78 | 6 | 92.86 (85.28, 96.69) | 88.24 (79.68, 93.48) | 88.64 (80.33, 93.71) | 92.59 (84.77, 96.56) | 90.53 (85.17, 94.09) |
Total | 110 | 26 | 80.88 (73.46, 86.61) | 88.24 (79.68, 93.48) | 91.67 (85.34, 95.41) | 74.26 (64.95, 81.78) | 83.71 (78.27, 88.00) |
The MSU crystal volume in the foot
Parameters |
B
| 95% CI for B
|
P value |
---|---|---|---|
Disease duration | 0.066 | 0.028, 0.104 | 0.001 |
Serum uric acid | 0.002 | 0.001, 0.003 | 0.001 |
Gout flares | 0.064 | 0.006, 0.122 | 0.031 |
Age | 0.014 | 0.004, 0.024 | 0.006 |
ESR | −0.008 | −0.014, −0.002 | 0.009 |