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11.10.2019 | Original Contributions

Duodenal-Jejunal Bypass Ameliorates Type 2 Diabetes Mellitus by Activating Insulin Signaling and Improving Glucose Utilization in the Brain

Zeitschrift:
Obesity Surgery
Autoren:
Na Li, Qing-Tao Yan, Qi Jing, Rui-Yan Pan, Huai-Jie Wang, Bin Jiang, Xian-Jun Li, Yi Wang, Jun-Hong Dong, Xue-Jian Wang, Mei-Jia Zhang, Qing-Guo Meng, Xiang-Zhen Li, Zhi-Jun Liu, Zhi-Qin Gao, Mei-Hua Qu
Wichtige Hinweise

Electronic supplementary material

The online version of this article (https://​doi.​org/​10.​1007/​s11695-019-04153-3) contains supplementary material, which is available to authorized users.
Na Li, Qing-Tao Yan and Qi Jing contributed equally to this work.

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Abstract

Background

Duodenal-jejunal bypass (DJB) can dramatically improve type 2 diabetes independent of weight loss and food restriction. Increasing evidence has demonstrated that brain insulin signaling plays an important role in the pathophysiology of type 2 diabetes. This study explores whether the antidiabetic effect of DJB is involved in brain insulin signaling activation and brain glucose utilization.

Methods

A diabetic rat model was established by high-fat and high-glucose diet. DJB or sham surgery was performed in diabetic rats. 18F-FDG PET scanning was used to detect glucose uptake in different organs, particularly in the brain. The levels of glucose transporters, glucose utilization-related proteins (HK1 and PFK2), insulin, and insulin signaling pathway-related proteins (InsR, IRS1/2, PI3K, and p-Akt) in the brain tissues were evaluated and analyzed.

Results

The results showed that DJB significantly improved basal glycemic parameters and reversed the decreasing glucose uptake in the brains of type 2 diabetic rats. DJB significantly increased not only the expression levels of brain insulin, IRS1/2, PI3K, and p-Akt but also the levels of the glucose utilization enzymes HK1 and PFK2 in the brain.

Conclusion

These results indicate that enhanced brain insulin signaling transduction and brain glucose utilization play important roles in the antidiabetic effect of DJB.

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Zusatzmaterial
High resolution image (TIF 10404 kb)
11695_2019_4153_MOESM1_ESM.tif
ESM 2 (DOCX 17 kb)
11695_2019_4153_MOESM2_ESM.docx
ESM 3 (DOCX 16 kb)
11695_2019_4153_MOESM3_ESM.docx
ESM 4 (DOCX 16 kb)
11695_2019_4153_MOESM4_ESM.docx
Literatur
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