Dr. Lynn has issued and pending patents which relate to the detection of sepsis and other clinical conditions by imaging time-matrix distortions. He is the owner of Lyntek Medical Technologies which develops sepsis detection software. He is the co-inventor of PateintStormTracker, visualization software for imaging and presentation of time-matrix distortions. He has licensed patents for monitor based pattern recognition to Covidien.
Decades of large, apparently well-designed clinical trials have failed to generate reproducible results in the investigation of many complex rapidly evolving and changing conditions such as sepsis. One possibility for the failure is that 20th century threshold science may be too simplistic to apply to complex rapidly changing conditions, especially those with unknown times of onset. There is an acute need to reconsider the fundamental validity of the application of simple threshold science in the study of complex rapidly evolving and changing conditions. In this letter, four potential axioms are presented which define a new science which assesses the probability of disease as a function of motion images of all the available clinical data.
Metz CE: Basic principles of ROC analysis. Semin Nucl Med. 1978, 4: 283-298. CrossRef
Opal SM, Dellinger RP, Vincent JL, Masur H, Angus DC: The next generation of sepsis clinical trial designs: what is next after the demise of recombinant human activated protein C?. Crit Care Med. 2014, Apr 8. [Epub ahead of print]
- Dynamic diagnostic relationism: a new diagnostic paradigm for complex rapidly changing clinical conditions
Lawrence A Lynn
- BioMed Central
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