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Erschienen in: European Archives of Psychiatry and Clinical Neuroscience 5/2018

08.02.2017 | Original Paper

Dysfunction of the blood-cerebrospinal fluid-barrier and N-methyl-d-aspartate glutamate receptor antibodies in dementias

verfasst von: Mandy Busse, Ralf Kunschmann, Henrik Dobrowolny, Jessica Hoffmann, Bernhard Bogerts, Johann Steiner, Thomas Frodl, Stefan Busse

Erschienen in: European Archives of Psychiatry and Clinical Neuroscience | Ausgabe 5/2018

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Abstract

N-Methyl-d-aspartate glutamate receptor (NMDA-R) antibodies (Abs) could play a role in neurodegenerative disorders. Since, in these diseases, NMDA-R Abs were detected in serum, but only sporadic in cerebrospinal fluid (CSF), the origin and impact of the Abs are still unresolved. We examined the presence of NMDA-R Abs in serum and CSF using a cell-based immunofluorescence assay as well as the function of the blood-CSF-barrier (B-CSF-B) by determination of Q albumin (ratio of albumin in CSF and serum) in patients with mild cognitive impairment (MCI; N = 59) and different types of dementia, Alzheimer’s disease (AD; N = 156), subcortical ischemic vascular dementia (SIVD; N = 61), and frontotemporal dementia (FTD; N = 34). Serum IgA/IgM NMDA-R Abs and/or a disturbed B-CSF-B were sporadically present in all investigated patients’ groups. In AD, these Abs often developed during the disease course. Patients with either no hippocampal atrophy and/or no AD-related characteristic changes in CSF, referred to “non-classical” AD, were characterized by seropositivity at diagnosis and loss of function of the B-CSF-B showed a progressive decline in cognitive functions and a poor prognosis. Our data indicate that NMDA-R Abs are present in different types of dementia and elderly healthy individuals. In combination with disturbed B-CSF-B integrity, they seem to promote their pathological potential on cognitive decline, and thus, a subgroup of dementia patients with these unique characteristics might inform clinicians.
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Metadaten
Titel
Dysfunction of the blood-cerebrospinal fluid-barrier and N-methyl-d-aspartate glutamate receptor antibodies in dementias
verfasst von
Mandy Busse
Ralf Kunschmann
Henrik Dobrowolny
Jessica Hoffmann
Bernhard Bogerts
Johann Steiner
Thomas Frodl
Stefan Busse
Publikationsdatum
08.02.2017
Verlag
Springer Berlin Heidelberg
Erschienen in
European Archives of Psychiatry and Clinical Neuroscience / Ausgabe 5/2018
Print ISSN: 0940-1334
Elektronische ISSN: 1433-8491
DOI
https://doi.org/10.1007/s00406-017-0768-z

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