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27.02.2024 | Short Communication

Dysregulated 24 h melatonin secretion associated with intrinsically photosensitive retinal ganglion cell function in diabetic retinopathy: a cross-sectional study

verfasst von: Sirimon Reutrakul, Jason C. Park, J. Jason McAnany, Felix Y. Chau, Kirstie K. Danielson, Bharati Prasad, Andrew Cross, Stephanie Sintetas, Julie Law, Silvana Pannain, Sarida Pratuangtham, Eve Van Cauter, Erin C. Hanlon

Erschienen in: Diabetologia | Ausgabe 6/2024

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Abstract

Aims/hypothesis

The aim of this study was to explore whether diabetic retinopathy is associated with alterations of the circadian system, and to examine the role of reduced intrinsically photosensitive retinal ganglion cell (ipRGC) function.

Methods

Participants with type 2 diabetes, with diabetic retinopathy (n=14) and without diabetic retinopathy (n=9) underwent 24 h blood sampling for melatonin and cortisol under controlled laboratory conditions. ipRGC function was inferred from the post-illumination pupil response (PIPR). Habitual sleep duration, efficiency and variability were assessed by actigraphy.

Results

Participants with diabetic retinopathy compared to participants without diabetic retinopathy had smaller PIPR (p=0.007), lower 24 h serum melatonin output (p=0.042) and greater day-to-day sleep variability (p=0.012). By contrast, 24 h cortisol profiles, sleep duration and efficiency were similar in both groups. Six individuals with diabetic retinopathy had no detectable dim-light melatonin onset. PIPR correlated with 24 h mean melatonin levels (r=0.555, p=0.007).

Conclusions/interpretation

ipRCG dysfunction in diabetic retinopathy is associated with disruptions of the 24 h melatonin rhythm, suggesting circadian dysregulation in diabetic retinopathy.

Graphical Abstract

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Titel: Dysregulated 24 h melatonin secretion associated with intrinsically photosensitive retinal ganglion cell function in diabetic retinopathy: a cross-sectional study
verfasst von: Sirimon Reutrakul
Jason C. Park
J. Jason McAnany
Felix Y. Chau
Kirstie K. Danielson
Bharati Prasad
Andrew Cross
Stephanie Sintetas
Julie Law
Silvana Pannain
Sarida Pratuangtham
Eve Van Cauter
Erin C. Hanlon
Publikationsdatum: 27.02.2024
Verlag: Springer Berlin Heidelberg
Erschienen in: Diabetologia / Ausgabe 6/2024
Print ISSN: 0012-186X
Elektronische ISSN: 1432-0428
DOI: https://doi.org/10.1007/s00125-024-06118-3

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Dysregulated 24 h melatonin secretion associated with intrinsically photosensitive retinal ganglion cell function in diabetic retinopathy: a cross-sectional study