Preterm infants are high risk for delayed neurodevelopment. The main goal is to develop a program of early intervention for very preterm infants that allows families to apply it continuously at home, and quantify the results of early parental stimulation on improvement of cognition and motor skills.
Randomized clinical Trial including inborn preterm infants with gestational age less than 32 weeks or birth weight less than 1500 g at 48 h after birth. Eligible for begin the intervention up to 7 days after birth. Study Protocol approved by the Brazilian national Committee of ethics in Research and by the institutional ethics committee.
Intervention group (IG): skin-to skin care by mother (kangaroo care) plus tactile-kinesthetic stimulation by mothers from randomization until hospital discharge when they receive a program of early intervention with 10 parents’ orientation and a total of 10 home visits independently of the standard evaluation and care that will be performed. Systematic early intervention program will be according to developmental milestones, anticipating in a month evolutionary step acquisition of motor and / or cognitive expected for corrected age. Active comparator with a Conventional Group (CG): standard care according to the routine care of the NICU and their needs in the follow up program. Neurodevelopment outcome with blinded evaluations in both groups between 12 and 18 months by Bayley Scales of Infant and Toddler Development third edition and Alberta Motor Infant scale will be performed. All evaluations will be conducted in the presence of parents or caregivers in a safe room for the child move around during the evaluation.
If we can show that a continuous and global early intervention at home performed by low income families is better than the standard care for very preterm infants, this kind of program may be applied elsewhere in the world. We received grants by Bill and Melinda Gates Foundation, DECIT, Cnpq and Health Ministry. Grand Challenges Brazil: All Children Thriving.
March of Dimes, PMNCH, Save the Children, WHO. Born too Soon : The global action report on preterm birth. World Health Organization. Geneva, 2012.
Guinsburg R, de Almeida MF, de Castro JS, Silveira RC, Caldas JP, Fiori HH, et al. Death or survival with major morbidity in VLBW infants born at Brazilian neonatal research network centers. J Matern Fetal Neonatal Med. 2015;2:1–5.
American Academy of Pediatrics. Follow-up care of high-risk infants. Pediatrics. 2004;114:1377–97. CrossRef
Spittle A, Orion J, Anderson P, Boyd R, Doyle LW. Early developmental intervention programmes post-hospital discharge to prevent motor and cognitive impairments in preterm infants. Cochrane Database Syst Rev. 2012; issue 12 Art n :CD005495
Melnyk BM, Alpert-Gillis L, Feinstein NF, Fairbanks E, Czarniak-Schultz N, Hust D, et al. Improving cognitive development of low-birth-weight premature infants with the COPE program: a pilot study of the benefit of early NICU intervention with mothers. Res Nurs Health. 2001;24(5):373–89. CrossRefPubMed
Valentini NC, Saccani R. Escala Motora Infantil de Alberta: validação para uma população gaúcha. Rev Paul Pediatr. 2011;29(2):231–8. CrossRef
Bayley N. Manual for the Bayley scales of infant and toddler development. 3rd ed. San Antonio, TX: Psychological Corporation; 2006.
Morgan C, Novak I, Dale RC, Guzzetta A, Badawi N. GAME (Goals - Activity - Motor Enrichment): protocol of a single blind randomised controlled trial of motor training, parent education and environmental enrichment for infants at high risk of cerebral palsy. BMC Neurol. 2014;14:203. CrossRefPubMedPubMedCentral
Biringen Z, Derscheid D, Vliegen N, Closson L, Easterbrooks MA. Emotional availability (EA): theoretical background, empirical research using the EA scales, and clinical applications. Dev Rev. 2012;34(2):114–67. CrossRef
- Early intervention program for very low birth weight preterm infants and their parents: a study protocol
Rita C. Silveira
Eliane Wagner Mendes
Rubia Nascimento Fuentefria
Nadia Cristina Valentini
Renato S. Procianoy
- BioMed Central
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