Early onset breast cancer: differences in risk factors, tumor phenotype, and genotype between North African and South European women
- 05.08.2017
- Brief Report
Erschienen in:
- Verfasst von
-
Carole Corsini
Carole Corsini
- Department of Cancer Genetics, University of Montpellier and University Hospital (CHU), Montpellier, France
-
Sarra Henouda
Sarra Henouda
- University of Mentouri brothers, Constantine, Algeria
-
Dalel Ben Nejima
Dalel Ben Nejima
- Department of Biology, University of Sciences of Tunis, Tunis, Tunisia
-
Héléna Bertet
Héléna Bertet
- Department of medical information, University Hospital, Montpellier, France
-
Alain Toledano
Alain Toledano
- Department of radiotherapy, Hartmann Radiotherapy Center, American Hospital of Paris, Neuilly, France
-
Hamouda Boussen
Hamouda Boussen
- Department of oncology, Abderrahmen Mami Hospital, Ariana, Tunisia
-
Faouzi Habib
Faouzi Habib
- Department of oncology, Oncology Center Al Azhar, Rabat, Morocco
-
Asma Mouhout
Asma Mouhout
- Department of oncology, Oncology Center Al Azhar, Rabat, Morocco
-
Ahmed Gaballah
Ahmed Gaballah
- Alfa Cure Center and Ain Shams University-Hospitals, Cairo, Egypt
-
Hesham El Ghazaly
Hesham El Ghazaly
- Alfa Cure Center and Ain Shams University-Hospitals, Cairo, Egypt
-
Céline Bourgier
Céline Bourgier
- Department of radiotherapy, Cancer Institute of Montpellier, ICM Val d’Aurelle, Montpellier, France
-
Isabelle Coupier
Isabelle Coupier
- Department of Cancer Genetics, University of Montpellier and University Hospital (CHU), Montpellier, France
-
Virginie Galibert
Virginie Galibert
- Department of Cancer Genetics, University of Montpellier and University Hospital (CHU), Montpellier, France
-
Karen Baudry
Karen Baudry
- Department of Cancer Genetics, University of Montpellier and University Hospital (CHU), Montpellier, France
-
Paul Vilquin
Paul Vilquin
- Hormonal and cellular biology laboratory, University Hospital, Montpellier, France
-
Louise Biquard
Louise Biquard
- Polytechnique school, Palaiseau, France
-
Jean-Marc Rey
Jean-Marc Rey
- Hormonal and cellular biology laboratory, University Hospital, Montpellier, France
-
Yazid Belkacemi
Yazid Belkacemi
- Department of radiation oncology and Henri Mondor breast center, APHP Henri Mondor University Hospital, University of Paris-Est Creteil (UPEC), Creteil, France
-
Paul Ihout
Paul Ihout
- Department of radiotherapy, Hartmann Radiotherapy Center, American Hospital of Paris, Neuilly, France
-
David Khayat
David Khayat
- Department of radiotherapy, Hartmann Radiotherapy Center, American Hospital of Paris, Neuilly, France
-
Marie-Christine Picot
Marie-Christine Picot
- Department of medical information, University Hospital, Montpellier, France
-
Assia Bensalem
Assia Bensalem
- Department of oncology, EH Didouche Mourad and medical University, Constantine, Algeria
-
Pascal Pujol
Korrespondierender Autor Pascal Pujol
- Department of Cancer Genetics, University of Montpellier and University Hospital (CHU), Montpellier, France
- Unité d’oncogénétique, Centre Hospitalier Universitaire de Montpellier, 34295, Montpellier cedex 5, France
- Erschienen in
- Breast Cancer Research and Treatment | Ausgabe 2/2017
Abstract
Purpose
This report compares the risk factors, the tumor phenotypes, and the BRCA1/BRCA2 genotype of early onset breast cancer (EOBC) patients between Southern Europe and North Africa.
Methods
Four hundred and fifty six women with invasive EOBC (≤40 years) were prospectively included from four centers in France (n = 270) and four centers in North Africa (Algeria, Egypt, Morocco, Tunisia; n = 186). Life style, tumor phenotype, familial history, BRCA1/BRCA2 genotype were compared between the two populations.
Results
We found an older age at menarche, a higher number of childbearing, a more frequent breastfeeding, a higher body mass index, a lower use of oral contraceptives in North African women compared to French women. TNM stage at diagnosis was higher in North African women than in French women. North African women had a lower incidence of triple negative and proliferative (Ki 67 index > 20%) tumors. There was a lower rate of BRCA1 mutation in North Africa (7 vs. 15%, P = 0.02). Three putative BRCA1/2 founder mutations were identified in North Africa.
Conclusions
In EOBC, we found significant differences in risk factors, phenotype and a higher incidence of BRCA1 mutations in Southern Europe as compared to North Africa. The worst prognosis previously reported for EOBC in North Africa is more likely due to a higher stage at diagnosis than to a more aggressive phenotype, since triple negative tumors are more common in Southern Europe and advanced tumors in North Africa.
Anzeige
- Titel
- Early onset breast cancer: differences in risk factors, tumor phenotype, and genotype between North African and South European women
- Verfasst von
-
Carole Corsini
Sarra Henouda
Dalel Ben Nejima
Héléna Bertet
Alain Toledano
Hamouda Boussen
Faouzi Habib
Asma Mouhout
Ahmed Gaballah
Hesham El Ghazaly
Céline Bourgier
Isabelle Coupier
Virginie Galibert
Karen Baudry
Paul Vilquin
Louise Biquard
Jean-Marc Rey
Yazid Belkacemi
Paul Ihout
David Khayat
Marie-Christine Picot
Assia Bensalem
Pascal Pujol
- Publikationsdatum
- 05.08.2017
- Verlag
- Springer US
- Erschienen in
-
Breast Cancer Research and Treatment / Ausgabe 2/2017
Print ISSN: 0167-6806
Elektronische ISSN: 1573-7217 - DOI
- https://doi.org/10.1007/s10549-017-4434-y
Dieser Inhalt ist nur sichtbar, wenn du eingeloggt bist und die entsprechende Berechtigung hast.
