Early onset primary Sjögren syndrome, clinical and laboratory characteristics
- 27.03.2020
- Original Article
Erschienen in:
- Verfasst von
- Müçteba Enes Yayla
- Zehra Karaman
- Murat Torgutalp
- Ayşe Bahar Keleşoğlu Dinçer
- Emine Gözde Aydemir Gülöksüz
- Serdar Sezer
- Didem Şahin Eroğlu
- Mehmet Levent Yüksel
- Tahsin Murat Turgay
- Gülay Kınıklı
- Aşkın Ateş
- Erschienen in
- Clinical Rheumatology | Ausgabe 9/2020
Abstract
Introduction/objectives
Primary Sjögren syndrome (pSS) is usually encountered between the fourth and sixth decades. It is known that the age of onset in autoimmune diseases may affect the clinical features. In this study, we aimed to investigate the clinical and laboratory characteristics of early onset pSS patients.
Method
The data of 352 pSS patients were analyzed retrospectively. The patients were divided into two groups as those with the onset age of 35 or younger (early-onset) and those with the onset age of older than 35. The clinical, laboratory, and serological characteristics of the two groups were compared. p < 0.05 was considered statistically significant.
Results
Forty patients in the group with an onset age of 35 or younger (11.4%) and 312 patients with an onset age of older than 35 (88.6%) were analyzed. The frequency of skin (22.5% vs 1.9%, p < 0.001) and renal involvement (10% vs 2.2%, p = 0.026) was significantly higher in the early-onset group than the late-onset group. There was no significant difference between the two groups in terms of xerostomia, eye dryness, arthritis, and other systemic involvement. Anti-Ro52 positivity (p = 0.04), elevated serum IgG levels (p = 0.004), and low C4 (p = 0.002) presence were more frequent in the early-onset group.
Conclusions
Consequently, it is seen that the clinical phenotype of early-onset pSS patients may be different to those with later onset. Especially the more frequent observation of poor prognostic factors at early-onset ages shows the necessity to monitor these patients more regularly.
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Key points:
• The clinical and laboratory features of patients with early-onset primary Sjogren syndrome may differ from late-onset patients.
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- Titel
- Early onset primary Sjögren syndrome, clinical and laboratory characteristics
- Verfasst von
-
Müçteba Enes Yayla
Zehra Karaman
Murat Torgutalp
Ayşe Bahar Keleşoğlu Dinçer
Emine Gözde Aydemir Gülöksüz
Serdar Sezer
Didem Şahin Eroğlu
Mehmet Levent Yüksel
Tahsin Murat Turgay
Gülay Kınıklı
Aşkın Ateş
- Publikationsdatum
- 27.03.2020
- Verlag
- Springer International Publishing
- Erschienen in
-
Clinical Rheumatology / Ausgabe 9/2020
Print ISSN: 0770-3198
Elektronische ISSN: 1434-9949 - DOI
- https://doi.org/10.1007/s10067-020-05017-3
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