Early osteosclerotic changes predict chemotherapy response in non-small-cell lung cancer patients with bone metastases
- 12.04.2018
- Computed Tomography
Erschienen in:
- Verfasst von
- Dailin Rong
- Yize Mao
- Qiuxia Yang
- Shuhang Xu
- Qianqian Zhao
- Rong Zhang
- Erschienen in
- European Radiology | Ausgabe 10/2018
Abstract
Objectives
To explore the relationship between osteosclerotic changes and chemotherapy response in non-small-cell lung cancer (NSCLC) patients with bone metastases (BM).
Methods
Fifty-two NSCLC patients with BM were enrolled from 1 January 2010–31 June 2015 and divided into two groups based on their CT features: an osteosclerotic change (OC) group and a no-osteosclerotic change (NOC) group. The disease control rate (DCR) was evaluated, and progression-free survival (PFS) was analysed using Kaplan-Meier curves. Univariate and multivariate Cox regression analyses were performed to analyse the factors that could affect PFS.
Results
Osteosclerotic changes were observed in 35/52 patients. The median interval when osteosclerotic changes occurred was 2 months (range 1–3 months) after chemotherapy. The OC group had a significantly higher 3-month DCR than the NOC group (p < 0.001). The OC group had a higher 1-year PFS rate than the NOC group (1-year PFS: 74.9% vs. 30.2%, p < 0.001). Univariate Cox regression analysis indicated that pathological subtype (HR = 4.419; 95% CI = 1.635–11.941, p = 0.003) and osteosclerotic changes (HR = 0.199; 95% CI = 0.083–0.477, p < 0.001) were significant predictors of PFS.
Conclusion
Early osteosclerotic changes predict chemotherapy response in NSCLC patients with BM.
Key Points
• Osteosclerotic changes were prevalent CT features after chemotherapy in NSCLC patients.
• Osteosclerotic changes were positively related to increased 3-month DCR.
• Osteosclerotic changes were positively related to increased 1-year PFS rate.
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- Titel
- Early osteosclerotic changes predict chemotherapy response in non-small-cell lung cancer patients with bone metastases
- Verfasst von
-
Dailin Rong
Yize Mao
Qiuxia Yang
Shuhang Xu
Qianqian Zhao
Rong Zhang
- Publikationsdatum
- 12.04.2018
- Verlag
- Springer Berlin Heidelberg
- Erschienen in
-
European Radiology / Ausgabe 10/2018
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084 - DOI
- https://doi.org/10.1007/s00330-017-5253-6
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