Erschienen in:
01.07.2011 | Original Article
Eccentric stimulation reveals an involvement of FGF6 in muscle resistance to mechanical stress
verfasst von:
Iman Laziz, Arnaud Ferry, Anne-Sophie Armand, Claude Louis Gallien, Bruno Della Gaspera, F. Charbonnier, C. Chanoine
Erschienen in:
European Journal of Applied Physiology
|
Ausgabe 7/2011
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Abstract
The objective of this report was to analyse a potential role for FGF6 in muscle resistance to mechanical stress. Normal or regenerating muscles of FGF6 (−/−) mice versus wild-type mice were submitted to different protocols of damaging eccentric contractions (eccentric electrostimulation and intermittent downhill exercise). Then muscular structural properties were analysed by histological and immunochemistry techniques to evaluate the post-injury muscle recovery; their muscle contractile parameters (maximal tetanic force, kinetics properties and fatigue resistance) were assessed. The absence of FGF6 causes (1) a fast-to-slow myofibre type switch in adult control and regenerating Tibialis anterior (TA) muscle; (2) muscle weakness in regenerating muscles in animals submitted to eccentric exercise protocols due to aberrant extensive necrotic zones. These observations point out a crucial and unexpected role for FGF6 in muscle integrity and muscle protection against mechanical stress.