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11.03.2024 | Echokardiografie | Übersichten

Geschichte der Kontrastechokardiographie

verfasst von: Dr. Andreas Helfen, Prof. Dr. Harald Becher

Erschienen in: Die Kardiologie | Ausgabe 3/2024

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Zusammenfassung

Die Entwicklung der Kontrastechokardiographie erstreckt sich über mehr als 50 Jahre. Die Besonderheit der Ultraschallkontrastmittel besteht darin, dass nennenswerte Kontrasteffekte nur dann zu erzielen sind, wenn Mikrogasbläschen in der Injektionslösung vorhanden sind. Dazu mussten Kontrastmittel und spezifische echokardiographische Techniken entwickelt werden. Meilensteine waren die Zulassung von stabilen, i.v. applizierbaren Kontrastmitteln und die Verfügbarkeit von Harmonic Imaging und kontrastspezifischen Ultraschallmethoden auf den Echokardiographiegeräten. Die experimentelle und klinische Forschung wurde von deutschen Wissenschaftlern und Klinikern entscheidend mitgeprägt und hat zur weltweiten Etablierung der Kontrastechokardiographie in der klinischen Diagnostik beigetragen. Wesentliche Studien und die beteiligten Wissenschaftler und Kliniker werden vorgestellt. Die Translation der Studienergebnisse in die klinische Praxis findet sich in den Anweisungen zur Kontrastechokardiographie im Manual zur Indikation und Durchführung spezieller echokardiographischer Anwendungen von 2021 der AG Kardiovaskulärer Ultraschall der Deutschen Gesellschaft für Kardiologie (DGK).
Fußnoten
1
Becher H. Persönliche Mitteilung.
 
Literatur
1.
Zurück zum Zitat Senior R, Becher H, Monaghan M, Agati L, Zamorano J, Vanoverschelde JL, Nihoyannopoulos P, Edvardsen T, Lancelloti P (2017) Clinical Practice of Contrast Echocardiography: Recommendation by the European Association of Cardiovascular Imaging (EACVI). Eur Heart J Cardiovasc Imaging 18(11):1205–1205PubMed Senior R, Becher H, Monaghan M, Agati L, Zamorano J, Vanoverschelde JL, Nihoyannopoulos P, Edvardsen T, Lancelloti P (2017) Clinical Practice of Contrast Echocardiography: Recommendation by the European Association of Cardiovascular Imaging (EACVI). Eur Heart J Cardiovasc Imaging 18(11):1205–1205PubMed
2.
Zurück zum Zitat Porter TR, Mulvagh SL, Abdelmoneim SS, Becher H, Belcik JT, Bierig M, Choy J, Gaibazzi N, Gillam LD, Janardhanan R, Kutty S, Leong-Poi H, Lindner JR, Main ML, Mathias W Jr., Park MM, Senior R, Villanueva F (2018) Clinical Applications of Ultrasonic Enhancing Agents in Echocardiography: 2018 American Society of Echocardiography Guidelines Update. J Am Soc Echocardiogr 31(3):241–274PubMed Porter TR, Mulvagh SL, Abdelmoneim SS, Becher H, Belcik JT, Bierig M, Choy J, Gaibazzi N, Gillam LD, Janardhanan R, Kutty S, Leong-Poi H, Lindner JR, Main ML, Mathias W Jr., Park MM, Senior R, Villanueva F (2018) Clinical Applications of Ultrasonic Enhancing Agents in Echocardiography: 2018 American Society of Echocardiography Guidelines Update. J Am Soc Echocardiogr 31(3):241–274PubMed
3.
Zurück zum Zitat Hagendorff A, Helfen A, Flachskampf FA, Ewen S, Kruck S, La Rosée K, Knierim J, Voigt JU, Kreidel F, Fehske W, Brandt R, Zahn R, Knebel F (2021) Manual zur Indikation und Durchführung spezieller echokardiographischer Anwendungen. Kardiologe 15:595–641 Hagendorff A, Helfen A, Flachskampf FA, Ewen S, Kruck S, La Rosée K, Knierim J, Voigt JU, Kreidel F, Fehske W, Brandt R, Zahn R, Knebel F (2021) Manual zur Indikation und Durchführung spezieller echokardiographischer Anwendungen. Kardiologe 15:595–641
4.
Zurück zum Zitat Werdan K, Baldus St, Bauersachs J et al (2020) Curriculum Kardiologie, 2., aktualisierte Auflage. Kardiologe 14:505–536 Werdan K, Baldus St, Bauersachs J et al (2020) Curriculum Kardiologie, 2., aktualisierte Auflage. Kardiologe 14:505–536
5.
Zurück zum Zitat Gramiak R, Shah PM (1968) Echocardiography of the aortic root. Invest Radiol 3:356PubMed Gramiak R, Shah PM (1968) Echocardiography of the aortic root. Invest Radiol 3:356PubMed
6.
Zurück zum Zitat Kremkau FW, Gramiak R, Carstensen EL et al (1970) Ultrasonic detection of cavitation at catheter tips. Am J Roentgenol 110:177 Kremkau FW, Gramiak R, Carstensen EL et al (1970) Ultrasonic detection of cavitation at catheter tips. Am J Roentgenol 110:177
7.
Zurück zum Zitat Meltzer RS, Tickner EG, Sahines TP, Popp RL (1980) The source of ultrasound contrast effect. J Clin Ultrasound 8:121PubMed Meltzer RS, Tickner EG, Sahines TP, Popp RL (1980) The source of ultrasound contrast effect. J Clin Ultrasound 8:121PubMed
8.
Zurück zum Zitat Becher H, Langenstein B, Krebber HJ, Hanrath P (1984) Kontrast-echokardiografischer Nachweis einer traumatisch bdeingten Fistel zwischen Aortenwurzel und rechtem Vorhof. Herz/Kreislauf 1:38–40 Becher H, Langenstein B, Krebber HJ, Hanrath P (1984) Kontrast-echokardiografischer Nachweis einer traumatisch bdeingten Fistel zwischen Aortenwurzel und rechtem Vorhof. Herz/Kreislauf 1:38–40
9.
Zurück zum Zitat Schreiner G, Mohr-Kahaly S, Erbel R, Meyer J (1985) Echoventrikulografie mittels Gelifundol, anstelle der Cineventrikulografie. In: Erberl R, Meyer J, Brennecke R (Hrsg) Fortschritte der Echokardiografie. Springer, Berlin, S 152–157 Schreiner G, Mohr-Kahaly S, Erbel R, Meyer J (1985) Echoventrikulografie mittels Gelifundol, anstelle der Cineventrikulografie. In: Erberl R, Meyer J, Brennecke R (Hrsg) Fortschritte der Echokardiografie. Springer, Berlin, S 152–157
10.
Zurück zum Zitat Schartl M, Fritsch T, Friedmann W, Lange L (1984) Quantifizierung myokardialer Perfusionsdefekte mittels zweidimensionaler Kontrastechokardiografie. Z Kardiol 73:560–567PubMed Schartl M, Fritsch T, Friedmann W, Lange L (1984) Quantifizierung myokardialer Perfusionsdefekte mittels zweidimensionaler Kontrastechokardiografie. Z Kardiol 73:560–567PubMed
11.
Zurück zum Zitat Berwing K (1993) Myokardiale Kontrast-Echokardiografie. Schattauer, Stuttgart, New York Berwing K (1993) Myokardiale Kontrast-Echokardiografie. Schattauer, Stuttgart, New York
12.
Zurück zum Zitat Berwing K, Schlepper M (1988) Echocardiographic imaging of the left ventricle by peripheral intravenous injection of echo contrast agent. Am Heart J 115(2):399–408PubMed Berwing K, Schlepper M (1988) Echocardiographic imaging of the left ventricle by peripheral intravenous injection of echo contrast agent. Am Heart J 115(2):399–408PubMed
13.
Zurück zum Zitat Mudra H, Zwehl W, Klauss V, Haufe M, Theisen K (1991) Myokardiale Kontrastechokardiografie mit sonikiertem Iopromid vor und nach Koronarangioplasie. Z Kardiol 80:367–372PubMed Mudra H, Zwehl W, Klauss V, Haufe M, Theisen K (1991) Myokardiale Kontrastechokardiografie mit sonikiertem Iopromid vor und nach Koronarangioplasie. Z Kardiol 80:367–372PubMed
14.
Zurück zum Zitat Mudra H, Klauss V, Meissner O, Metz J, Zwehl W, Theisen K (1993) Reproducibility of myocardial contrast echocardiography in human studies. Echocardiography 10(3):255–263PubMed Mudra H, Klauss V, Meissner O, Metz J, Zwehl W, Theisen K (1993) Reproducibility of myocardial contrast echocardiography in human studies. Echocardiography 10(3):255–263PubMed
15.
Zurück zum Zitat Mudra H, Zwehl W, Klauss V, Haufe M, Spes C, Theisen K (1991) Myocardial contrast echocardiography with sonicated iopromide (Ultravist 370) before and after coronary angioplasty. Z Kardiol 80(6):367–372PubMed Mudra H, Zwehl W, Klauss V, Haufe M, Spes C, Theisen K (1991) Myocardial contrast echocardiography with sonicated iopromide (Ultravist 370) before and after coronary angioplasty. Z Kardiol 80(6):367–372PubMed
16.
Zurück zum Zitat Klauss V, Mudra H, Sbarouni E, Meissner O, Metz J, Theisen K (1995) Myocardial contrast echocardiography for assessment of papaverine vasodilator response in patients with angiographically normal coronary arteries and in patients after orthotopic heart transplantation. Z Kardiol 84(10):852–859PubMed Klauss V, Mudra H, Sbarouni E, Meissner O, Metz J, Theisen K (1995) Myocardial contrast echocardiography for assessment of papaverine vasodilator response in patients with angiographically normal coronary arteries and in patients after orthotopic heart transplantation. Z Kardiol 84(10):852–859PubMed
17.
Zurück zum Zitat Seward JB, Tajik AJ, Spangler JG et al (1975) Echocardiographic contrast studies: Initial experience. Mayo Clin Proc 50:163–192PubMed Seward JB, Tajik AJ, Spangler JG et al (1975) Echocardiographic contrast studies: Initial experience. Mayo Clin Proc 50:163–192PubMed
18.
Zurück zum Zitat Hausmann D, Mügge A, Daniel WG (1995) Identification of patent foramen ovale permitting paradoxic embolism. J Am Coll Cardiol 26(4):1030–1038PubMed Hausmann D, Mügge A, Daniel WG (1995) Identification of patent foramen ovale permitting paradoxic embolism. J Am Coll Cardiol 26(4):1030–1038PubMed
19.
Zurück zum Zitat Hausmann D, Mügge A, Becht I, Daniel WG (1992) Diagnosis of patent foramen ovale by transesophageal echocardiography and association with cerebral and peripheral embolic events. Am J Cardiol 70(6):668–672PubMed Hausmann D, Mügge A, Becht I, Daniel WG (1992) Diagnosis of patent foramen ovale by transesophageal echocardiography and association with cerebral and peripheral embolic events. Am J Cardiol 70(6):668–672PubMed
20.
Zurück zum Zitat Lambertz H, Schweizer P, Erbel R, Meyer J, Effert S (1982) Value of contrast echocardiography in the diagnosis of tricuspid insufficiency. Z Kardiol 71(11):771–778PubMed Lambertz H, Schweizer P, Erbel R, Meyer J, Effert S (1982) Value of contrast echocardiography in the diagnosis of tricuspid insufficiency. Z Kardiol 71(11):771–778PubMed
21.
Zurück zum Zitat Himelman RB, Schiller N saline enhanced contrast echocardiography Himelman RB, Schiller N saline enhanced contrast echocardiography
22.
Zurück zum Zitat Grube E, Fritzsch T (1986) Improved reproducibility of contrast echocardiography by SH U 454. Experimental studies using digital subtraction echocardiography. Z Kardiol 75(6):355–362PubMed Grube E, Fritzsch T (1986) Improved reproducibility of contrast echocardiography by SH U 454. Experimental studies using digital subtraction echocardiography. Z Kardiol 75(6):355–362PubMed
23.
Zurück zum Zitat Becher H, Schlief R (1989) Improved sensitivity of color Doppler by SHU 454. Am J Cardiol 64:374–377PubMed Becher H, Schlief R (1989) Improved sensitivity of color Doppler by SHU 454. Am J Cardiol 64:374–377PubMed
24.
Zurück zum Zitat Von Bibra H, Stempfle H, Poll A, Schlief R, Emslander H (1991) Echo contrast agents improve flow display of color Doppler: in vitro studies. Echocardiography 8(5):533–540 Von Bibra H, Stempfle H, Poll A, Schlief R, Emslander H (1991) Echo contrast agents improve flow display of color Doppler: in vitro studies. Echocardiography 8(5):533–540
25.
Zurück zum Zitat Feinstein SB, Cheirif J, Ten Cate FJ, Silverman PR, Heidenreich PA, Dick C, Desir RM, Armstrong WF, Quinones MA, Shah PM (1990) Safety and efficacy of a new transpulmonary ultrasound contrast agent: initial multicenter clinical results. J Am Coll Cardiol 16(2):316–324PubMed Feinstein SB, Cheirif J, Ten Cate FJ, Silverman PR, Heidenreich PA, Dick C, Desir RM, Armstrong WF, Quinones MA, Shah PM (1990) Safety and efficacy of a new transpulmonary ultrasound contrast agent: initial multicenter clinical results. J Am Coll Cardiol 16(2):316–324PubMed
26.
Zurück zum Zitat Smith MD, Elion JL, McClure RR et al (1989) Left heart opacification with peripheral venous injection of a new saccharide echo contrast agent. J Am Coll Cardiol 13:1622–1628PubMed Smith MD, Elion JL, McClure RR et al (1989) Left heart opacification with peripheral venous injection of a new saccharide echo contrast agent. J Am Coll Cardiol 13:1622–1628PubMed
27.
Zurück zum Zitat Schlief R, Staks T, Mahler M et al (1990) Successful opacification of the left heart chambers on echocardiographic examination after intravenous injection of a new saccharide-based contrast agent. Echocardiography 7:61–64PubMed Schlief R, Staks T, Mahler M et al (1990) Successful opacification of the left heart chambers on echocardiographic examination after intravenous injection of a new saccharide-based contrast agent. Echocardiography 7:61–64PubMed
28.
Zurück zum Zitat Beckmann S, Schartl M, Bocksch W, Paeprer H (1993) Stress echocardiography: evaluation of left ventricular function after administration of the transpulmonary echo contrast medium SHU 508 A. Z Kardiol 82(5):317–323PubMed Beckmann S, Schartl M, Bocksch W, Paeprer H (1993) Stress echocardiography: evaluation of left ventricular function after administration of the transpulmonary echo contrast medium SHU 508 A. Z Kardiol 82(5):317–323PubMed
29.
Zurück zum Zitat von Bibra H, Becher H, Firschke C, Schlief R, Emslander HP, Schömig A (1993) Enhancement of mitral regurgitation and normal left atrial color Doppler flow signals with peripheral venous injection of a saccharide-based contrast agent. J Am Coll Cardiol 22(2):521–528 von Bibra H, Becher H, Firschke C, Schlief R, Emslander HP, Schömig A (1993) Enhancement of mitral regurgitation and normal left atrial color Doppler flow signals with peripheral venous injection of a saccharide-based contrast agent. J Am Coll Cardiol 22(2):521–528
30.
Zurück zum Zitat von Bibra H, Sutherland G, Becher H, Neudert J, Nihoyannopoulos P (1995) Clinical evaluation of left heart Doppler contrast enhancement by a saccharide-based transpulmonary contrast agent. The Levovist Cardiac Working Group. J Am Coll Cardiol 25(2):500–508 von Bibra H, Sutherland G, Becher H, Neudert J, Nihoyannopoulos P (1995) Clinical evaluation of left heart Doppler contrast enhancement by a saccharide-based transpulmonary contrast agent. The Levovist Cardiac Working Group. J Am Coll Cardiol 25(2):500–508
31.
Zurück zum Zitat Lepper W, Franke A, von Bibra H, Becher H, Holz K, Näbauer M, Vered Z, Hoffmann R, Flachskampf FA, Hanrath P (2001) Shu 508 A (Levovist)-enhanced Doppler echocardiography improves the assessment of valvular heart disease. Echocardiography 18(5):363–372PubMed Lepper W, Franke A, von Bibra H, Becher H, Holz K, Näbauer M, Vered Z, Hoffmann R, Flachskampf FA, Hanrath P (2001) Shu 508 A (Levovist)-enhanced Doppler echocardiography improves the assessment of valvular heart disease. Echocardiography 18(5):363–372PubMed
32.
Zurück zum Zitat Firschke C, Köberl B, von Bibra H, Horcher J, Schömig A (1997) Combined use of contrast-enhanced 2‑dimensional and color Doppler echocardiography for improved left ventricular endocardial border delineation using Levovist, a new venous echocardiographic contrast agent. Int J Card Imaging 13(2):137–144PubMed Firschke C, Köberl B, von Bibra H, Horcher J, Schömig A (1997) Combined use of contrast-enhanced 2‑dimensional and color Doppler echocardiography for improved left ventricular endocardial border delineation using Levovist, a new venous echocardiographic contrast agent. Int J Card Imaging 13(2):137–144PubMed
33.
Zurück zum Zitat Bartel, Müller S, Baumgart D, Mathew BT, Haude M, Erbel R (1999) Improved High-Frequency Transthoracic Flow Velocity Measurement in the Left Anterior Descending Coronary Artery After Intravenous Peripheral Injection of Levovist. J Am Soc Echocardiogr 12:252–256PubMed Bartel, Müller S, Baumgart D, Mathew BT, Haude M, Erbel R (1999) Improved High-Frequency Transthoracic Flow Velocity Measurement in the Left Anterior Descending Coronary Artery After Intravenous Peripheral Injection of Levovist. J Am Soc Echocardiogr 12:252–256PubMed
34.
Zurück zum Zitat Lambertz H, Tries HP, Stein T, Lethen H (1999) Noninvasive assessment of coronary flow reserve with transthoracic signal-enhanced Doppler echocardiography. J Am Soc Echocardiogr 12:186–195PubMed Lambertz H, Tries HP, Stein T, Lethen H (1999) Noninvasive assessment of coronary flow reserve with transthoracic signal-enhanced Doppler echocardiography. J Am Soc Echocardiogr 12:186–195PubMed
35.
Zurück zum Zitat Helfen A (2019) Multiparametric stress echocardiography. In: Becher H, Helfen A (Hrsg) Contrast echocardiography—compendium for clinical practice. Springer/Nature, Switzerland, S 263–308 Helfen A (2019) Multiparametric stress echocardiography. In: Becher H, Helfen A (Hrsg) Contrast echocardiography—compendium for clinical practice. Springer/Nature, Switzerland, S 263–308
36.
Zurück zum Zitat Senior R, Andersson O, Caidahl K, Cartens P, Herregods MC, Jenni R et al (2000) Enhanced left ventricular delineation with an intravenous injection of SonoVue, a new echocardiographic contrast agent: a European multicentre clinical trial. Echocardiography 17:705–711PubMed Senior R, Andersson O, Caidahl K, Cartens P, Herregods MC, Jenni R et al (2000) Enhanced left ventricular delineation with an intravenous injection of SonoVue, a new echocardiographic contrast agent: a European multicentre clinical trial. Echocardiography 17:705–711PubMed
37.
Zurück zum Zitat Cohen JL, Cheirif J, Segar DS et al (1998) Improved left ventricular endocardial border delineation and opaci-cation with Optison (FS069), a new echocardiographic contrast agent. J Am Coll Cardiol 32:746–752PubMed Cohen JL, Cheirif J, Segar DS et al (1998) Improved left ventricular endocardial border delineation and opaci-cation with Optison (FS069), a new echocardiographic contrast agent. J Am Coll Cardiol 32:746–752PubMed
38.
Zurück zum Zitat Kitzman DW, Goldman ME, Gillam LD, Cohen JL, Aurigemma GP, Gottdiener JS (2000) Efficacy and safety of the novel ultrasound contrast agent perflutren (definity) in patients with suboptimal baseline left ventricular echocardiographic images. Am J Cardiol 86(6):669–674PubMed Kitzman DW, Goldman ME, Gillam LD, Cohen JL, Aurigemma GP, Gottdiener JS (2000) Efficacy and safety of the novel ultrasound contrast agent perflutren (definity) in patients with suboptimal baseline left ventricular echocardiographic images. Am J Cardiol 86(6):669–674PubMed
39.
Zurück zum Zitat Becher H, Tiemann K, Schlosser T, Pohl C, Nanda NC, Averkiou MA, Powers J, Lüderitz B (1998) Improvement in Endocardial Border Delineation Using Tissue Harmonic Imaging. Echocardiography 15(5):511–518PubMed Becher H, Tiemann K, Schlosser T, Pohl C, Nanda NC, Averkiou MA, Powers J, Lüderitz B (1998) Improvement in Endocardial Border Delineation Using Tissue Harmonic Imaging. Echocardiography 15(5):511–518PubMed
40.
Zurück zum Zitat Becher H, Tiemann K, Schlief R, Lüderitz B, Nanda NC (1997) Harmonic Power Doppler Contrast Echocardiography: Preliminary Clinical Results. Echocardiography 14(6 Pt 1):637PubMed Becher H, Tiemann K, Schlief R, Lüderitz B, Nanda NC (1997) Harmonic Power Doppler Contrast Echocardiography: Preliminary Clinical Results. Echocardiography 14(6 Pt 1):637PubMed
41.
Zurück zum Zitat Köster J, Schlosser T, Pohl C, Lentz C, Lohmaier S, Veltmann C, Kuntz-Hehner S, Omran H, Lüderitz B, Becher H, Tiemann K (2001) Blood flow assessment by ultrasound-induced destruction of echocontrast agents using harmonic power Doppler imaging: which parameters determine contrast replenishment curves? Echocardiography 18(1):1–8PubMed Köster J, Schlosser T, Pohl C, Lentz C, Lohmaier S, Veltmann C, Kuntz-Hehner S, Omran H, Lüderitz B, Becher H, Tiemann K (2001) Blood flow assessment by ultrasound-induced destruction of echocontrast agents using harmonic power Doppler imaging: which parameters determine contrast replenishment curves? Echocardiography 18(1):1–8PubMed
42.
Zurück zum Zitat Hagendorff A, Gockritz A, Wunderlich A, Frigstad S, Pfeiffer D, Becher H (2002) Determinants of myocardial hypoperfusion analyzed for the interventricular septum using power Doppler harmonic imaging with contrast echocardiography in humans: A methodologic approach for clinical practice. J Am Soc Echocardiogr 15:404–415PubMed Hagendorff A, Gockritz A, Wunderlich A, Frigstad S, Pfeiffer D, Becher H (2002) Determinants of myocardial hypoperfusion analyzed for the interventricular septum using power Doppler harmonic imaging with contrast echocardiography in humans: A methodologic approach for clinical practice. J Am Soc Echocardiogr 15:404–415PubMed
43.
Zurück zum Zitat Hagendorff A, Goeckritz A, Pfeiffer D, Becher H (2004) Myocardial contrast echocardiography demonstrates myocardial hypoperfusion in the LAD territory in patients with acute chest pain at rest—a prospective study using power Doppler harmonic imaging with intravenous bolus application. Eur J Echocardiogr 5(2):132–141PubMed Hagendorff A, Goeckritz A, Pfeiffer D, Becher H (2004) Myocardial contrast echocardiography demonstrates myocardial hypoperfusion in the LAD territory in patients with acute chest pain at rest—a prospective study using power Doppler harmonic imaging with intravenous bolus application. Eur J Echocardiogr 5(2):132–141PubMed
44.
Zurück zum Zitat Hagendorff A, Pfeiffer D, Rother T, Becher H (2003) Myocardial contrast echocardiography for assessment of myocardial perfusion at rest in a patient with left main coronary artery stenosis. Z Kardiol 92(10):876–883PubMed Hagendorff A, Pfeiffer D, Rother T, Becher H (2003) Myocardial contrast echocardiography for assessment of myocardial perfusion at rest in a patient with left main coronary artery stenosis. Z Kardiol 92(10):876–883PubMed
45.
Zurück zum Zitat Hagendorff A, Goeckritz A, Neugebauer A, Rother T, Linke T, Pfeiffer D, Becher H (2003) Assessment of regional myocardial hypoperfusion with myocardial contrast echocardiography using intravenous bolus application in patients with acute chest pain: a double case report. Eur J Echocardiogr 4(4):320–326PubMed Hagendorff A, Goeckritz A, Neugebauer A, Rother T, Linke T, Pfeiffer D, Becher H (2003) Assessment of regional myocardial hypoperfusion with myocardial contrast echocardiography using intravenous bolus application in patients with acute chest pain: a double case report. Eur J Echocardiogr 4(4):320–326PubMed
46.
Zurück zum Zitat Tiemann K, Lohmeier S, Kuntz S, Köster J, Pohl C, Burns PRT, Nanda NC, Lüderitz B, Becher H (1999) Real-Time Contrast Echo Assessment of Myocardial Perfusion at Low Emission Power: First Experimental and Clinical Results Using Power Pulse Inversion Imaging. Echocardiography 16(8):799–809PubMed Tiemann K, Lohmeier S, Kuntz S, Köster J, Pohl C, Burns PRT, Nanda NC, Lüderitz B, Becher H (1999) Real-Time Contrast Echo Assessment of Myocardial Perfusion at Low Emission Power: First Experimental and Clinical Results Using Power Pulse Inversion Imaging. Echocardiography 16(8):799–809PubMed
47.
Zurück zum Zitat Tiemann K, Veltmann C, Ghanem A, Lohmaier S, Bruce M, Kuntz-Hehner S, Pohl C, Ehlgen A, Schlosser T, Omran H, Becher H (2001) The impact of emission power on the destruction of echo contrast agents and on the origin of tissue harmonic signals using power pulse-inversion imaging. Ultrasound Med Biol 27(11):1525–1533PubMed Tiemann K, Veltmann C, Ghanem A, Lohmaier S, Bruce M, Kuntz-Hehner S, Pohl C, Ehlgen A, Schlosser T, Omran H, Becher H (2001) The impact of emission power on the destruction of echo contrast agents and on the origin of tissue harmonic signals using power pulse-inversion imaging. Ultrasound Med Biol 27(11):1525–1533PubMed
48.
Zurück zum Zitat Hoffmann R, von Bardeleben S, Kasprzak J, Borges A, ten Cate F, Firschke C, Lafitte S, Al-Saadi N, Kuntz-Hehner S, Engelhardt M, Vanoverschelde JL, Becher H (2006) Analysis of Regional Left Ventricular Function by Cineventriculography, Cardiac Magnetic Resonance Imaging, Unenhanced and Contrast Enhanced Echocardiography. A Multicenter Comparison of Methods. J Am Coll Cardiol 47(1):121–128PubMed Hoffmann R, von Bardeleben S, Kasprzak J, Borges A, ten Cate F, Firschke C, Lafitte S, Al-Saadi N, Kuntz-Hehner S, Engelhardt M, Vanoverschelde JL, Becher H (2006) Analysis of Regional Left Ventricular Function by Cineventriculography, Cardiac Magnetic Resonance Imaging, Unenhanced and Contrast Enhanced Echocardiography. A Multicenter Comparison of Methods. J Am Coll Cardiol 47(1):121–128PubMed
49.
Zurück zum Zitat Hoffmann R, von Bardeleben S, Ten Cate F, Borges AC, Kasprzak J, Firschke C, Lafitte S, Al-Saadi N, Kuntz-Hehner S, Engelhardt M, Becher H, Vanoverschelde JL (2005) Assessment of systolic left ventricular function: a multi-centre comparison of cineventriculography, cardiac magnetic resonance imaging, unenhanced and contrast-enhanced echocardiography. Eur Heart J 26(6):607–616PubMed Hoffmann R, von Bardeleben S, Ten Cate F, Borges AC, Kasprzak J, Firschke C, Lafitte S, Al-Saadi N, Kuntz-Hehner S, Engelhardt M, Becher H, Vanoverschelde JL (2005) Assessment of systolic left ventricular function: a multi-centre comparison of cineventriculography, cardiac magnetic resonance imaging, unenhanced and contrast-enhanced echocardiography. Eur Heart J 26(6):607–616PubMed
50.
Zurück zum Zitat Hoffmann R, von Bardeleben S, Kasprzak J, Borges A, ten Cate F, Firschke C, Lafitte S, Al-Saadi N, Kuntz-Hehner S, Engelhardt M, Vanoverschelde JL, Becher H (2006) Analysis of regional left ventricular function. Cardiol Rev 23(8):26–28 Hoffmann R, von Bardeleben S, Kasprzak J, Borges A, ten Cate F, Firschke C, Lafitte S, Al-Saadi N, Kuntz-Hehner S, Engelhardt M, Vanoverschelde JL, Becher H (2006) Analysis of regional left ventricular function. Cardiol Rev 23(8):26–28
51.
Zurück zum Zitat Hoffmann R, von Bardeleben S, Barletta G, Pasques A, Kasprzak J, Greis C, Becher H (2014) Analysis of Regional Left Ventricular Function Using 2D and 3D Unenhanced and Contrast Enhanced Echocardiography in Comparison to Cineventriculography and Cardiac Magnetic Resonance. A Multicenter Comparison of Methods. Am J Cardiol 113(2):395–401PubMed Hoffmann R, von Bardeleben S, Barletta G, Pasques A, Kasprzak J, Greis C, Becher H (2014) Analysis of Regional Left Ventricular Function Using 2D and 3D Unenhanced and Contrast Enhanced Echocardiography in Comparison to Cineventriculography and Cardiac Magnetic Resonance. A Multicenter Comparison of Methods. Am J Cardiol 113(2):395–401PubMed
52.
Zurück zum Zitat Hoffmann R, Barletta G, von Bardeleben S, Vanoverschelde JL, Kasprzak J, Greis C, Becher H (2014) Analysis of Left Ventricular Volumes and Function—A Multicenter Comparison of Cineventriculography, Cardiac Magnetic Resonance Imaging, Unenhanced and Contrast Enhanced 2D and 3D Echocardiography. J Am Soc Echocardiogr 27(3):292–301PubMed Hoffmann R, Barletta G, von Bardeleben S, Vanoverschelde JL, Kasprzak J, Greis C, Becher H (2014) Analysis of Left Ventricular Volumes and Function—A Multicenter Comparison of Cineventriculography, Cardiac Magnetic Resonance Imaging, Unenhanced and Contrast Enhanced 2D and 3D Echocardiography. J Am Soc Echocardiogr 27(3):292–301PubMed
53.
Zurück zum Zitat Plana JC, Mikati IA, Dokainish H, Lakkis N, Abukhalil J, Davis R, Hetzell BC, Zoghbi WA (2008) A randomized cross-over study for evaluation of the effect of image optimization with contrast on the diagnostic accuracy of dobutamine echocardiography in coronary artery disease The OPTIMIZE Trial. JACC Cardiovasc Imaging 1(2):145–152PubMed Plana JC, Mikati IA, Dokainish H, Lakkis N, Abukhalil J, Davis R, Hetzell BC, Zoghbi WA (2008) A randomized cross-over study for evaluation of the effect of image optimization with contrast on the diagnostic accuracy of dobutamine echocardiography in coronary artery disease The OPTIMIZE Trial. JACC Cardiovasc Imaging 1(2):145–152PubMed
54.
Zurück zum Zitat Jung PH, Rieber J, Störk S, Hoyer C, Erhardt I, Nowotny A, Voelker W, Weidemann F, Ertl G, Klauss V, Angermann CE (2008) Effect of contrast application on interpretability and diagnostic value of dobutamine stress echocardiography in patients with intermediate coronary lesions: comparison with myocardial fractional flow reserve. Eur Heart J 29(20):2536–2543PubMed Jung PH, Rieber J, Störk S, Hoyer C, Erhardt I, Nowotny A, Voelker W, Weidemann F, Ertl G, Klauss V, Angermann CE (2008) Effect of contrast application on interpretability and diagnostic value of dobutamine stress echocardiography in patients with intermediate coronary lesions: comparison with myocardial fractional flow reserve. Eur Heart J 29(20):2536–2543PubMed
55.
Zurück zum Zitat Firschke C, Lindner JR, Wei K, Goodman NC, Skyba DM, Kaul S (1997) Myocardial perfusion imaging in the setting of coronary artery stenosis and acute myocardial infarction using venous injection of a second-generation echocardiographic contrast agent. Circulation 96:959–967PubMed Firschke C, Lindner JR, Wei K, Goodman NC, Skyba DM, Kaul S (1997) Myocardial perfusion imaging in the setting of coronary artery stenosis and acute myocardial infarction using venous injection of a second-generation echocardiographic contrast agent. Circulation 96:959–967PubMed
56.
Zurück zum Zitat Marwick TH, Brunken R, Meland N, Brochet E, Baer FM, Binder T, Flachskampf F, Kamp O, Nienaber C, Nihoyannopoulos P, Pierard L, Vanoverschelde JL, van der Wouw P, Lindvall K (1998) Accuracy and Feasibility of Contrast Echocardiography for Detection of Perfusion Defects in Routine Practice. Comparison With Wall Motion and Technetium-99m Sestamibi Single-Photon Emission Computed Tomography. J Am Coll Cardiol 32(5):1260–1269. https://doi.org/10.1016/s0735-1097(98)00373-8CrossRefPubMed Marwick TH, Brunken R, Meland N, Brochet E, Baer FM, Binder T, Flachskampf F, Kamp O, Nienaber C, Nihoyannopoulos P, Pierard L, Vanoverschelde JL, van der Wouw P, Lindvall K (1998) Accuracy and Feasibility of Contrast Echocardiography for Detection of Perfusion Defects in Routine Practice. Comparison With Wall Motion and Technetium-99m Sestamibi Single-Photon Emission Computed Tomography. J Am Coll Cardiol 32(5):1260–1269. https://​doi.​org/​10.​1016/​s0735-1097(98)00373-8CrossRefPubMed
57.
Zurück zum Zitat Senior R, Monaghan M, Main ML, Zamorano JL, Tiemann K, Agati L, Weissman NJ, Klein AL, Marwick TH, Ahmad M, DeMaria AN, Zabalgoitia M, Becher H, Kaul S, Udelson JE, Wackers FJ, Walovitch RC, Picard MH for the RAMP‑1 and RAMP‑2 Investigators. (2009) Detection of coronary artery disease with perfusion stress echocardiography using a novel ultrasound imaging agent: two Phase 3 international trials in comparison with radionuclide perfusion imaging. Eur J Echocardiogr 10:26–35PubMed Senior R, Monaghan M, Main ML, Zamorano JL, Tiemann K, Agati L, Weissman NJ, Klein AL, Marwick TH, Ahmad M, DeMaria AN, Zabalgoitia M, Becher H, Kaul S, Udelson JE, Wackers FJ, Walovitch RC, Picard MH for the RAMP‑1 and RAMP‑2 Investigators. (2009) Detection of coronary artery disease with perfusion stress echocardiography using a novel ultrasound imaging agent: two Phase 3 international trials in comparison with radionuclide perfusion imaging. Eur J Echocardiogr 10:26–35PubMed
58.
Zurück zum Zitat Senior R, Moreo A, Gaibazzi N, Agati L, Tiemann K, Shivalkar B, von Bardeleben S, Galiuto L, Lardoux H, Trocino G, Carrió I, Le Guludec D, Sambuceti G, Becher H, Colonna P, ten Cate F, Bramucci E, Cohen A, Bezante G, Aggeli C, Kasprzak JD (2013) Comparison of Sulfur Hexafluoride Microbubble (SonoVue)-Enhanced Myocardial Echocardiography to gated Single Photon Emission Computerized Tomography for the Detection of Significant Coronary Artery Disease: A Large European Multicentre Study. J Am Coll Cardiol 62(15):1353–1361PubMed Senior R, Moreo A, Gaibazzi N, Agati L, Tiemann K, Shivalkar B, von Bardeleben S, Galiuto L, Lardoux H, Trocino G, Carrió I, Le Guludec D, Sambuceti G, Becher H, Colonna P, ten Cate F, Bramucci E, Cohen A, Bezante G, Aggeli C, Kasprzak JD (2013) Comparison of Sulfur Hexafluoride Microbubble (SonoVue)-Enhanced Myocardial Echocardiography to gated Single Photon Emission Computerized Tomography for the Detection of Significant Coronary Artery Disease: A Large European Multicentre Study. J Am Coll Cardiol 62(15):1353–1361PubMed
59.
Zurück zum Zitat Arnold JR, Karamitsos TD, Pegg TJ, Francis JM, Olszewski R, Searle N, Senior R, Neubauer S, Becher H, Selvanayagam JB (2010) Adenosine Stress Myocardial Contrast Echocardiography for the Detection of Coronary Artery Disease: a comparison with Diagnostic Coronary Angiography and with Cardiovascular Magnetic Resonance. JACC Cardiovasc Imaging 3(9):934–943PubMed Arnold JR, Karamitsos TD, Pegg TJ, Francis JM, Olszewski R, Searle N, Senior R, Neubauer S, Becher H, Selvanayagam JB (2010) Adenosine Stress Myocardial Contrast Echocardiography for the Detection of Coronary Artery Disease: a comparison with Diagnostic Coronary Angiography and with Cardiovascular Magnetic Resonance. JACC Cardiovasc Imaging 3(9):934–943PubMed
60.
Zurück zum Zitat von Bibra H, Bone D, Niklasson U, Eurenius L, Hansen A (2002) Myocardial contrast echocardiography yields best accuracy using quantitative analysis of digital data from pulse inversion technique: comparison with second harmonic imaging and harmonic power Doppler during simultaneous dipyridamole stress SPECT studies. Eur J Echocardiogr 3(4):271–282 von Bibra H, Bone D, Niklasson U, Eurenius L, Hansen A (2002) Myocardial contrast echocardiography yields best accuracy using quantitative analysis of digital data from pulse inversion technique: comparison with second harmonic imaging and harmonic power Doppler during simultaneous dipyridamole stress SPECT studies. Eur J Echocardiogr 3(4):271–282
61.
Zurück zum Zitat Lepper W, Nowak B, Franke A, Schroder J, Janssens U, Kaul S, Buell U, Hanrath P, Hoffmann R (2003) Myocardial contrast echocardiography, single-photon emission computed tomography, and regional function analysis for coronary stenosis description during vasodilator stress. Am J Cardiol 91:445–448PubMed Lepper W, Nowak B, Franke A, Schroder J, Janssens U, Kaul S, Buell U, Hanrath P, Hoffmann R (2003) Myocardial contrast echocardiography, single-photon emission computed tomography, and regional function analysis for coronary stenosis description during vasodilator stress. Am J Cardiol 91:445–448PubMed
62.
Zurück zum Zitat Korosoglou G, da Silva KG Jr, Labadze N, Dubart AE, Hansen A, Rosenberg M, Zehelein J, Kuecherer H (2004) Real-time myocardial contrast echocardiography for pharmacologic stress testing: Is quantitative estimation of myocardial blood flow reserve necessary? J Am Soc Echocardiogr pp:1–9 Korosoglou G, da Silva KG Jr, Labadze N, Dubart AE, Hansen A, Rosenberg M, Zehelein J, Kuecherer H (2004) Real-time myocardial contrast echocardiography for pharmacologic stress testing: Is quantitative estimation of myocardial blood flow reserve necessary? J Am Soc Echocardiogr pp:1–9
63.
Zurück zum Zitat Wasmeier GH, Asmussen S, Voigt JU, Flachskampf FA, Daniel WG, Nixdorff U (2008) Real-time myocardial contrast stress echocardiography using bolus application. Ultrasound Med Biol 34(11):1724–1731PubMed Wasmeier GH, Asmussen S, Voigt JU, Flachskampf FA, Daniel WG, Nixdorff U (2008) Real-time myocardial contrast stress echocardiography using bolus application. Ultrasound Med Biol 34(11):1724–1731PubMed
64.
Zurück zum Zitat von der Recke G, Schmidt H, Illien S, Luderitz B, Omran H (2002) Use of transesophageal contrast echocardiography for excluding left atrial appendage thrombi in patients with atrial fibrillation before cardioversion. J Am Soc Echocardiogr 15(10 Pt 2):1256–1261PubMed von der Recke G, Schmidt H, Illien S, Luderitz B, Omran H (2002) Use of transesophageal contrast echocardiography for excluding left atrial appendage thrombi in patients with atrial fibrillation before cardioversion. J Am Soc Echocardiogr 15(10 Pt 2):1256–1261PubMed
65.
Zurück zum Zitat Jung PH, Mueller M, Schuhmann C, Eickhoff M, Schneider P, Seemueller G, Dutton R, Rieber J, Kääb S, Hae-Young S (2013) Contrast enhanced transesophageal echocardiography in patients with atrial fibrillation referred to electrical cardioversion improves atrial thrombus detection and may reduce associated thromboembolic events. Cardiovasc Ultrasound 11(1):1PubMedPubMedCentral Jung PH, Mueller M, Schuhmann C, Eickhoff M, Schneider P, Seemueller G, Dutton R, Rieber J, Kääb S, Hae-Young S (2013) Contrast enhanced transesophageal echocardiography in patients with atrial fibrillation referred to electrical cardioversion improves atrial thrombus detection and may reduce associated thromboembolic events. Cardiovasc Ultrasound 11(1):1PubMedPubMedCentral
66.
Zurück zum Zitat Helfen A, Becher H (2018) Kursbuch Kontrast-Echokardiografie. Springer, Heidelberg Helfen A, Becher H (2018) Kursbuch Kontrast-Echokardiografie. Springer, Heidelberg
67.
Zurück zum Zitat Becher H, Helfen A (Hrsg) (2019) Contrast echocardiography—compendium for clinical practice. Springer/Nature, Switzerland Becher H, Helfen A (Hrsg) (2019) Contrast echocardiography—compendium for clinical practice. Springer/Nature, Switzerland
68.
Zurück zum Zitat Ozawa K, Lindner JR (2020) Ultrasound molecular imaging: insights into cardiovascular pathology. J Echocardiogr 18:86–93PubMedPubMedCentral Ozawa K, Lindner JR (2020) Ultrasound molecular imaging: insights into cardiovascular pathology. J Echocardiogr 18:86–93PubMedPubMedCentral
69.
Zurück zum Zitat Davidson BP, Chadderdon SM, Belcik JT, Gupta S, Lindner JR (2014) Ischemic memory imaging in nonhuman primates with echocardiographic molecular imaging of selectin expression. J Am Soc Echocardiogr 27(7):786–793PubMedPubMedCentral Davidson BP, Chadderdon SM, Belcik JT, Gupta S, Lindner JR (2014) Ischemic memory imaging in nonhuman primates with echocardiographic molecular imaging of selectin expression. J Am Soc Echocardiogr 27(7):786–793PubMedPubMedCentral
70.
Zurück zum Zitat Schäfer S, Kliner S, Klinghammer L, Kaarmann H, Lucic I, Nixdorff U, Rosenschein U, Daniel WG, Flachskampf FA (2005) Influence of ultrasound operating parameters on ultrasound-induced thrombolysis in vitro. Ultrasound Med Biol 31:841–847PubMed Schäfer S, Kliner S, Klinghammer L, Kaarmann H, Lucic I, Nixdorff U, Rosenschein U, Daniel WG, Flachskampf FA (2005) Influence of ultrasound operating parameters on ultrasound-induced thrombolysis in vitro. Ultrasound Med Biol 31:841–847PubMed
71.
Zurück zum Zitat Aguiar MOD, Tavares BG, Tsutsui JM, Fava AM, Borges BC, Oliveira MT Jr, Soeiro A, Nicolau JC, Ribeiro HB, Chiang HP, Sbano JCN, Goldsweig A, Rochitte CE, Lopes BBC, Ramirez JAF, Kalil Filho R, Porter TR, Mathias W Jr. (2020) Sonothrombolysis Improves Myocardial Dynamics, and Microvascular Obstruct on Preventing Left Ventricular Remodeling in Patients with ST Elevation Myocardial Infarction. Circ Cardiovasc Imaging 13(4):e9536PubMed Aguiar MOD, Tavares BG, Tsutsui JM, Fava AM, Borges BC, Oliveira MT Jr, Soeiro A, Nicolau JC, Ribeiro HB, Chiang HP, Sbano JCN, Goldsweig A, Rochitte CE, Lopes BBC, Ramirez JAF, Kalil Filho R, Porter TR, Mathias W Jr. (2020) Sonothrombolysis Improves Myocardial Dynamics, and Microvascular Obstruct on Preventing Left Ventricular Remodeling in Patients with ST Elevation Myocardial Infarction. Circ Cardiovasc Imaging 13(4):e9536PubMed
72.
Zurück zum Zitat Bainey KR, Abulhamayel A, Aziz A, Becher H (2022) Sonothrombolysis Augments Reperfusion in ST-Elevation Myocardial Infarction With Primary Percutaneous Coronary Intervention: Insights From the SONOSTEMI Study. CJC Open 4:444–446 Bainey KR, Abulhamayel A, Aziz A, Becher H (2022) Sonothrombolysis Augments Reperfusion in ST-Elevation Myocardial Infarction With Primary Percutaneous Coronary Intervention: Insights From the SONOSTEMI Study. CJC Open 4:444–446
73.
Zurück zum Zitat Mason O’Neil R, Davidson BP, Sheeran P et al (2020) Augmentation of tissue perfusion in patients with peripheral artery disease using microbubble cavitation. JACC Cardiovasc Imaging 13:641–651PubMed Mason O’Neil R, Davidson BP, Sheeran P et al (2020) Augmentation of tissue perfusion in patients with peripheral artery disease using microbubble cavitation. JACC Cardiovasc Imaging 13:641–651PubMed
Metadaten
Titel
Geschichte der Kontrastechokardiographie
verfasst von
Dr. Andreas Helfen
Prof. Dr. Harald Becher
Publikationsdatum
11.03.2024
Verlag
Springer Medizin
Erschienen in
Die Kardiologie / Ausgabe 3/2024
Print ISSN: 2731-7129
Elektronische ISSN: 2731-7137
DOI
https://doi.org/10.1007/s12181-024-00681-0

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