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19.03.2021 | Original Paper

Economic analysis of open versus laparoscopic versus robotic hepatectomy: a systematic review and meta-analysis

verfasst von: Ioannis A. Ziogas, Alexandros P. Evangeliou, Konstantinos S. Mylonas, Dimitrios I. Athanasiadis, Panagiotis Cherouveim, David A. Geller, Richard D. Schulick, Sophoclis P. Alexopoulos, Georgios Tsoulfas

Erschienen in: The European Journal of Health Economics | Ausgabe 4/2021

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Abstract

Background

Following the publication of reports from landmark international consensuses (Louisville 2008 and Morioka 2014), minimally invasive hepatectomy became widely accepted as a legitimate alternative to open surgery. We aimed to compare the operative, hospitalization, and total economic costs of open (OLR) vs. laparoscopic (LLR) vs. robotic liver resection (RLR).

Methods

We performed a systematic literature review (end-of-search date: July 3, 2020) according to the PRISMA statement. Random-effects meta-analyses were conducted. Quality assessment was performed with the Cochrane Risk of Bias tool for randomized controlled trials, and the Newcastle–Ottawa Scale for non-randomized studies.

Results

Thirty-eight studies reporting on 3847 patients (1783 OLR; 1674 LLR; 390 RLR) were included. The operative costs of LLR were significantly higher than those of OLR, while subgroup analysis also showed higher operative costs in the LLR group for major hepatectomy, but no statistically significant difference for minor hepatectomy. Hospitalization costs were significantly lower in the LLR group, with subgroup analyses indicating lower costs for LLR in both major and minor hepatectomy series. No statistically significant difference was observed regarding total costs between LLR and OLR both overall and on subgroup analyses in either major or minor hepatectomy series. Meta-analyses showed higher operative, hospitalization, and total costs for RLR vs. LLR, but no statistically significant difference regarding total costs for RLR vs. OLR.

Conclusion

LLR’s higher operative costs are offset by lower hospitalization costs compared to OLR leading to no statistically significant difference in total costs, while RLR appears to be a more expensive alternative approach.
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Literatur
4.
Zurück zum Zitat Buell, J.F., Cherqui, D., Geller, D.A., O’Rourke, N., Iannitti, D., Dagher, I., Koffron, A.J., Thomas, M., Gayet, B., Han, H.S., Wakabayashi, G., Belli, G., Kaneko, H., Ker, C.G., Scatton, O., Laurent, A., Abdalla, E.K., Chaudhury, P., Dutson, E., Gamblin, C., D’Angelica, M., Nagorney, D., Testa, G., Labow, D., Manas, D., Poon, R.T., Nelson, H., Martin, R., Clary, B., Pinson, W.C., Martinie, J., Vauthey, J.N., Goldstein, R., Roayaie, S., Barlet, D., Espat, J., Abecassis, M., Rees, M., Fong, Y., McMasters, K.M., Broelsch, C., Busuttil, R., Belghiti, J., Strasberg, S., Chari, R.S.: Position on laparoscopic liver surgery. Ann. Surg. 250, 825–830 (2009). https://doi.org/10.1097/SLA.0b013e3181b3b2d8CrossRefPubMed Buell, J.F., Cherqui, D., Geller, D.A., O’Rourke, N., Iannitti, D., Dagher, I., Koffron, A.J., Thomas, M., Gayet, B., Han, H.S., Wakabayashi, G., Belli, G., Kaneko, H., Ker, C.G., Scatton, O., Laurent, A., Abdalla, E.K., Chaudhury, P., Dutson, E., Gamblin, C., D’Angelica, M., Nagorney, D., Testa, G., Labow, D., Manas, D., Poon, R.T., Nelson, H., Martin, R., Clary, B., Pinson, W.C., Martinie, J., Vauthey, J.N., Goldstein, R., Roayaie, S., Barlet, D., Espat, J., Abecassis, M., Rees, M., Fong, Y., McMasters, K.M., Broelsch, C., Busuttil, R., Belghiti, J., Strasberg, S., Chari, R.S.: Position on laparoscopic liver surgery. Ann. Surg. 250, 825–830 (2009). https://​doi.​org/​10.​1097/​SLA.​0b013e3181b3b2d8​CrossRefPubMed
5.
Zurück zum Zitat Wakabayashi, G., Cherqui, D., Geller, D.A., Buell, J.F., Kaneko, H., Han, H.S., Asbun, H., Orourke, N., Tanabe, M., Koffron, A.J., Tsung, A., Soubrane, O., Machado, M.A., Gayet, B., Troisi, R.I., Pessaux, P., Van Dam, R.M., Scatton, O., Abu Hilal, M., Belli, G., Kwon, C.H.D., Edwin, B., Choi, G.H., Aldrighetti, L.A., Cai, X., Cleary, S., Chen, K.-H., Schon, M.R., Sugioka, A., Tang, C.-N., Herman, P., Pekolj, J., Chen, X.-P., Dagher, I., Jarnagin, W., Yamamoto, M., Strong, R., Jagannath, P., Lo, C.-M., Clavien, P.-A., Kokudo, N., Barkun, J., Strasberg, S.M.: Recommendations for laparoscopic liver resection: a report from the second international consensus conference held in Morioka. Ann. Surg. 261, 619–629 (2015). https://doi.org/10.1097/SLA.0000000000001184CrossRefPubMed Wakabayashi, G., Cherqui, D., Geller, D.A., Buell, J.F., Kaneko, H., Han, H.S., Asbun, H., Orourke, N., Tanabe, M., Koffron, A.J., Tsung, A., Soubrane, O., Machado, M.A., Gayet, B., Troisi, R.I., Pessaux, P., Van Dam, R.M., Scatton, O., Abu Hilal, M., Belli, G., Kwon, C.H.D., Edwin, B., Choi, G.H., Aldrighetti, L.A., Cai, X., Cleary, S., Chen, K.-H., Schon, M.R., Sugioka, A., Tang, C.-N., Herman, P., Pekolj, J., Chen, X.-P., Dagher, I., Jarnagin, W., Yamamoto, M., Strong, R., Jagannath, P., Lo, C.-M., Clavien, P.-A., Kokudo, N., Barkun, J., Strasberg, S.M.: Recommendations for laparoscopic liver resection: a report from the second international consensus conference held in Morioka. Ann. Surg. 261, 619–629 (2015). https://​doi.​org/​10.​1097/​SLA.​0000000000001184​CrossRefPubMed
13.
Zurück zum Zitat Liberati, A., Altman, D.G., Tetzlaff, J., Mulrow, C., Gotzsche, P.C., Ioannidis, J.P.A., Clarke, M., Devereaux, P.J., Kleijnen, J., Moher, D.: The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: Explanation and elaboration. BMJ 339, b2700 (2009). https://doi.org/10.1136/bmj.b2700CrossRefPubMedPubMedCentral Liberati, A., Altman, D.G., Tetzlaff, J., Mulrow, C., Gotzsche, P.C., Ioannidis, J.P.A., Clarke, M., Devereaux, P.J., Kleijnen, J., Moher, D.: The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: Explanation and elaboration. BMJ 339, b2700 (2009). https://​doi.​org/​10.​1136/​bmj.​b2700CrossRefPubMedPubMedCentral
14.
Zurück zum Zitat Veritas Health Innovation. Covidence Systematic Review Software. Melbourne, Australia: Veritas Health Innovation, 2018. www.covidence.org. Accessed 3 July 2020 Veritas Health Innovation. Covidence Systematic Review Software. Melbourne, Australia: Veritas Health Innovation, 2018. www.​covidence.​org. Accessed 3 July 2020
15.
Zurück zum Zitat Wohlin, C.: Guidelines for snowballing in systematic literature studies and a replication in software engineering. In: Proceedings of the 18th International Conference on Evaluation and Assessment in Software Engineering, pp. 381–3810. ACM, New York (2014) Wohlin, C.: Guidelines for snowballing in systematic literature studies and a replication in software engineering. In: Proceedings of the 18th International Conference on Evaluation and Assessment in Software Engineering, pp. 381–3810. ACM, New York (2014)
19.
Zurück zum Zitat Higgins, J.P.T., Thomas, J., Chandler, J., Cumpston, M., Li, T., Page, M.J., Welch, V.A.: Cochrane Handbook for Systematic Reviews of Interventions version 6.1 (updated September 2020). Cochrane (2020) www.training.cochrane.org/handbook. Accessed 1 Dec 2020 Higgins, J.P.T., Thomas, J., Chandler, J., Cumpston, M., Li, T., Page, M.J., Welch, V.A.: Cochrane Handbook for Systematic Reviews of Interventions version 6.1 (updated September 2020). Cochrane (2020) www.​training.​cochrane.​org/​handbook. Accessed 1 Dec 2020
20.
28.
29.
Zurück zum Zitat Daskalaki, D., Gonzalez-Heredia, R., Brown, M., Bianco, F.M., Tzvetanov, I., Davis, M., Kim, J., Benedetti, E., Giulianotti, P.C.: Financial impact of the robotic approach in liver surgery: A comparative study of clinical outcomes and costs between the robotic and open technique in a single institution. J. Laparoendosc. Adv. Surg. Tech. 27, 375–382 (2017). https://doi.org/10.1089/lap.2016.0576CrossRef Daskalaki, D., Gonzalez-Heredia, R., Brown, M., Bianco, F.M., Tzvetanov, I., Davis, M., Kim, J., Benedetti, E., Giulianotti, P.C.: Financial impact of the robotic approach in liver surgery: A comparative study of clinical outcomes and costs between the robotic and open technique in a single institution. J. Laparoendosc. Adv. Surg. Tech. 27, 375–382 (2017). https://​doi.​org/​10.​1089/​lap.​2016.​0576CrossRef
33.
Zurück zum Zitat Kawaguchi, Y., Otsuka, Y., Kaneko, H., Nagai, M., Nomura, Y., Yamamoto, M., Otani, M., Ohashi, Y., Sugawara, K., Koike, D., Ishida, T., Kokudo, N., Tanaka, N.: Comparisons of financial and short-term outcomes between laparoscopic and open hepatectomy: Benefits for patients and hospitals. Surg. Today 46, 535–542 (2016). https://doi.org/10.1007/s00595-015-1189-0CrossRefPubMed Kawaguchi, Y., Otsuka, Y., Kaneko, H., Nagai, M., Nomura, Y., Yamamoto, M., Otani, M., Ohashi, Y., Sugawara, K., Koike, D., Ishida, T., Kokudo, N., Tanaka, N.: Comparisons of financial and short-term outcomes between laparoscopic and open hepatectomy: Benefits for patients and hospitals. Surg. Today 46, 535–542 (2016). https://​doi.​org/​10.​1007/​s00595-015-1189-0CrossRefPubMed
37.
39.
Zurück zum Zitat Bell, R., Pandanaboyana, S., Hanif, F., Shah, N., Hidalgo, E., Lodge, J.P.A., Toogood, G., Prasad, K.R.: A cost effective analysis of a laparoscopic versus an open left lateral sectionectomy in a liver transplant unit. HPB (Oxford) 17, 332–336 (2015). https://doi.org/10.1111/hpb.12354CrossRef Bell, R., Pandanaboyana, S., Hanif, F., Shah, N., Hidalgo, E., Lodge, J.P.A., Toogood, G., Prasad, K.R.: A cost effective analysis of a laparoscopic versus an open left lateral sectionectomy in a liver transplant unit. HPB (Oxford) 17, 332–336 (2015). https://​doi.​org/​10.​1111/​hpb.​12354CrossRef
44.
Zurück zum Zitat Abu Hilal, M., Di Fabio, F., Syed, S., Wiltshire, R., Dimovska, E., Turner, D., Primrose, J.N., Pearce, N.W.: Assessment of the financial implications for laparoscopic liver surgery: A single-centre UK cost analysis for minor and major hepatectomy. Surg. Endosc. 27, 2542–2550 (2013). https://doi.org/10.1007/s00464-012-2779-1CrossRefPubMed Abu Hilal, M., Di Fabio, F., Syed, S., Wiltshire, R., Dimovska, E., Turner, D., Primrose, J.N., Pearce, N.W.: Assessment of the financial implications for laparoscopic liver surgery: A single-centre UK cost analysis for minor and major hepatectomy. Surg. Endosc. 27, 2542–2550 (2013). https://​doi.​org/​10.​1007/​s00464-012-2779-1CrossRefPubMed
54.
57.
60.
Zurück zum Zitat Jajja, M.R., Maxwell, D., Hashmi, S.S., Meltzer, R.S., Lin, E., Sweeney, J.F., Sarmiento, J.M.: Standardization of operative technique in minimally invasive right hepatectomy: Improving cost-value relationship through value stream mapping in hepatobiliary surgery. HPB (Oxford) 21, 566–573 (2019). https://doi.org/10.1016/j.hpb.2018.09.012CrossRef Jajja, M.R., Maxwell, D., Hashmi, S.S., Meltzer, R.S., Lin, E., Sweeney, J.F., Sarmiento, J.M.: Standardization of operative technique in minimally invasive right hepatectomy: Improving cost-value relationship through value stream mapping in hepatobiliary surgery. HPB (Oxford) 21, 566–573 (2019). https://​doi.​org/​10.​1016/​j.​hpb.​2018.​09.​012CrossRef
61.
Zurück zum Zitat Fretland, A.A., Dagenborg, V.J., Bjornelv, G.M.W., Kazaryan, A.M., Kristiansen, R., Fagerland, M.W., Hausken, J., Tonnessen, T.I., Abildgaard, A., Barkhatov, L., Yaqub, S., Rosok, B.I., Bjornbeth, B.A., Andersen, M.H., Flatmark, K., Aas, E., Edwin, B.: Laparoscopic versus open resection for colorectal liver metastases: The OSLO-COMET randomized controlled trial. Ann. Surg. 267, 199–207 (2018). https://doi.org/10.1097/SLA.0000000000002353CrossRefPubMed Fretland, A.A., Dagenborg, V.J., Bjornelv, G.M.W., Kazaryan, A.M., Kristiansen, R., Fagerland, M.W., Hausken, J., Tonnessen, T.I., Abildgaard, A., Barkhatov, L., Yaqub, S., Rosok, B.I., Bjornbeth, B.A., Andersen, M.H., Flatmark, K., Aas, E., Edwin, B.: Laparoscopic versus open resection for colorectal liver metastases: The OSLO-COMET randomized controlled trial. Ann. Surg. 267, 199–207 (2018). https://​doi.​org/​10.​1097/​SLA.​0000000000002353​CrossRefPubMed
69.
Zurück zum Zitat Untereiner, X., Cagnet, A., Memeo, R., De Blasi, V., Tzedakis, S., Piardi, T., Severac, F., Mutter, D., Kianmanesh, R., Marescaux, J., Sommacale, D., Pessaux, P.: Short-term and middle-term evaluation of laparoscopic hepatectomies compared with open hepatectomies: A propensity score matching analysis. World J. Gastrointest. Surg. 8, 643–650 (2016). https://doi.org/10.4240/wjgs.v8.i9.643CrossRefPubMedPubMedCentral Untereiner, X., Cagnet, A., Memeo, R., De Blasi, V., Tzedakis, S., Piardi, T., Severac, F., Mutter, D., Kianmanesh, R., Marescaux, J., Sommacale, D., Pessaux, P.: Short-term and middle-term evaluation of laparoscopic hepatectomies compared with open hepatectomies: A propensity score matching analysis. World J. Gastrointest. Surg. 8, 643–650 (2016). https://​doi.​org/​10.​4240/​wjgs.​v8.​i9.​643CrossRefPubMedPubMedCentral
71.
Zurück zum Zitat Liu, L., Li, N.: Feasibility and advantages of large liver hemangioma treated with laparoscopic microwave ablation. Hepatogastroenterology 61, 1068–1073 (2014)PubMed Liu, L., Li, N.: Feasibility and advantages of large liver hemangioma treated with laparoscopic microwave ablation. Hepatogastroenterology 61, 1068–1073 (2014)PubMed
73.
74.
Zurück zum Zitat Fretland, Å.A., Dagenborg, V.J., Waaler Bjørnelv, G.M., Aghayan, D.L., Kazaryan, A.M., Barkhatov, L., Kristiansen, R., Fagerland, M.W., Edwin, B., Andersen, M.H.: Quality of life from a randomized trial of laparoscopic or open liver resection for colorectal liver metastases. Br. J. Surg. 106, 1372–1380 (2019). https://doi.org/10.1002/bjs.11227CrossRefPubMed Fretland, Å.A., Dagenborg, V.J., Waaler Bjørnelv, G.M., Aghayan, D.L., Kazaryan, A.M., Barkhatov, L., Kristiansen, R., Fagerland, M.W., Edwin, B., Andersen, M.H.: Quality of life from a randomized trial of laparoscopic or open liver resection for colorectal liver metastases. Br. J. Surg. 106, 1372–1380 (2019). https://​doi.​org/​10.​1002/​bjs.​11227CrossRefPubMed
75.
Zurück zum Zitat Slim, A., Garancini, M., Di Sandro, S., Mangoni, I., Lauterio, A., Giacomoni, A., De Carlis, L.: Laparoscopic versus open liver surgery: a single center analysis of post-operative in-hospital and post-discharge results. Langenbeck’s Arch. Surg. 397, 1305–1311 (2012). https://doi.org/10.1007/s00423-012-0992-yCrossRef Slim, A., Garancini, M., Di Sandro, S., Mangoni, I., Lauterio, A., Giacomoni, A., De Carlis, L.: Laparoscopic versus open liver surgery: a single center analysis of post-operative in-hospital and post-discharge results. Langenbeck’s Arch. Surg. 397, 1305–1311 (2012). https://​doi.​org/​10.​1007/​s00423-012-0992-yCrossRef
83.
Zurück zum Zitat Okuno, M., Goumard, C., Mizuno, T., Omichi, K., Tzeng, C.-W.D., Chun, Y.S., Aloia, T.A., Fleming, J.B., Lee, J.E., Vauthey, J.-N., Conrad, C.: Operative and short-term oncologic outcomes of laparoscopic versus open liver resection for colorectal liver metastases located in the posterosuperior liver: A propensity score matching analysis. Surg. Endosc. 32, 1776–1786 (2018). https://doi.org/10.1007/s00464-017-5861-xCrossRefPubMed Okuno, M., Goumard, C., Mizuno, T., Omichi, K., Tzeng, C.-W.D., Chun, Y.S., Aloia, T.A., Fleming, J.B., Lee, J.E., Vauthey, J.-N., Conrad, C.: Operative and short-term oncologic outcomes of laparoscopic versus open liver resection for colorectal liver metastases located in the posterosuperior liver: A propensity score matching analysis. Surg. Endosc. 32, 1776–1786 (2018). https://​doi.​org/​10.​1007/​s00464-017-5861-xCrossRefPubMed
86.
Zurück zum Zitat Kasai, M., Cipriani, F., Gayet, B., Aldrighetti, L., Ratti, F., Sarmiento, J.M., Scatton, O., Kim, K.-H., Dagher, I., Topal, B., Primrose, J., Nomi, T., Fuks, D., Abu Hilal, M.: Laparoscopic versus open major hepatectomy: A systematic review and meta-analysis of individual patient data. Surgery 163, 985–995 (2018). https://doi.org/10.1016/j.surg.2018.01.020CrossRefPubMed Kasai, M., Cipriani, F., Gayet, B., Aldrighetti, L., Ratti, F., Sarmiento, J.M., Scatton, O., Kim, K.-H., Dagher, I., Topal, B., Primrose, J., Nomi, T., Fuks, D., Abu Hilal, M.: Laparoscopic versus open major hepatectomy: A systematic review and meta-analysis of individual patient data. Surgery 163, 985–995 (2018). https://​doi.​org/​10.​1016/​j.​surg.​2018.​01.​020CrossRefPubMed
100.
Zurück zum Zitat Ho, C., Tsakonas, E., Tran, K., Cimon, K., Severn, M., Mierzwinski-Urban, M., Corcos, J., Pautler, S.: Robot-assisted surgery compared with open surgery and laparoscopic surgery: clinical effectiveness and economic analyses. Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2011 Sep. (CADTH Technology Report, No. 137.) 5, Economic Analysis. Ho, C., Tsakonas, E., Tran, K., Cimon, K., Severn, M., Mierzwinski-Urban, M., Corcos, J., Pautler, S.: Robot-assisted surgery compared with open surgery and laparoscopic surgery: clinical effectiveness and economic analyses. Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2011 Sep. (CADTH Technology Report, No. 137.) 5, Economic Analysis.
101.
Zurück zum Zitat D’Annibale, A., Fiscon, V., Trevisan, P., Pozzobon, M., Gianfreda, V., Sovernigo, G., Morpurgo, E., Orsini, C., Del Monte, D.: The da Vinci robot in right adrenalectomy: considerations on technique. Surg. Laparosc. Endosc. Percutan. Tech. 14, 38–41 (2004)CrossRefPubMed D’Annibale, A., Fiscon, V., Trevisan, P., Pozzobon, M., Gianfreda, V., Sovernigo, G., Morpurgo, E., Orsini, C., Del Monte, D.: The da Vinci robot in right adrenalectomy: considerations on technique. Surg. Laparosc. Endosc. Percutan. Tech. 14, 38–41 (2004)CrossRefPubMed
Metadaten
Titel
Economic analysis of open versus laparoscopic versus robotic hepatectomy: a systematic review and meta-analysis
verfasst von
Ioannis A. Ziogas
Alexandros P. Evangeliou
Konstantinos S. Mylonas
Dimitrios I. Athanasiadis
Panagiotis Cherouveim
David A. Geller
Richard D. Schulick
Sophoclis P. Alexopoulos
Georgios Tsoulfas
Publikationsdatum
19.03.2021
Verlag
Springer Berlin Heidelberg
Erschienen in
The European Journal of Health Economics / Ausgabe 4/2021
Print ISSN: 1618-7598
Elektronische ISSN: 1618-7601
DOI
https://doi.org/10.1007/s10198-021-01277-1