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Erschienen in: Pituitary 5/2019

30.04.2019 | Cushing's Syndrome

Ectopic cushing’s syndrome due to corticotropin releasing hormone

verfasst von: Manouchehr Nakhjavani, Alireza Amirbaigloo, Soghra Rabizadeh, Fabio Rotondo, Kalman Kovacs, Ali A. Ghazi

Erschienen in: Pituitary | Ausgabe 5/2019

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Abstract

Cushing’s syndrome (CS) secondary to corticotropin releasing hormone (CRH) producing tumors is rare. In this paper we present an Iranian patient who was admitted to our hospital with classic signs and symptoms of CS. Laboratory evaluation revealed high serum and urine cortisol which could not be suppressed with dexamethasone. Abdominal CT scan revealed a mass in abdominal cavity. A percutaneous needle biopsy was performed and histopathologic evaluation revealed that the mass was a neuroendocrine tumor. A multi-disciplinary approach including resection of the mass, bilateral adrenalectomy somatostatin analogue and chemotherapy was applied for management of the disease. Extensive review of English literature focusing on the topic from 1971 to 2018 revealed that there have been only 75 similar cases. Clinical, laboratory, imaging, histopathologic characteristics and managements of these patients will also be discussed in this paper.
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Metadaten
Titel
Ectopic cushing’s syndrome due to corticotropin releasing hormone
verfasst von
Manouchehr Nakhjavani
Alireza Amirbaigloo
Soghra Rabizadeh
Fabio Rotondo
Kalman Kovacs
Ali A. Ghazi
Publikationsdatum
30.04.2019
Verlag
Springer US
Erschienen in
Pituitary / Ausgabe 5/2019
Print ISSN: 1386-341X
Elektronische ISSN: 1573-7403
DOI
https://doi.org/10.1007/s11102-019-00965-9

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