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Erschienen in:

Open Access 28.09.2016

Effect of a Mediterranean type diet on inflammatory and cartilage degradation biomarkers in patients with osteoarthritis

verfasst von: J. Dyer, G. Davison, S. M. Marcora, Alexis R. Mauger

Erschienen in: The journal of nutrition, health & aging | Ausgabe 5/2017

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Abstract

Objectives

To investigate the effects of a Mediterranean type diet on patients with osteoarthritis (OA).

Participants

Ninety-nine volunteers with OA (aged 31 - 90 years) completed the study (83% female).

Setting

Southeast of England, UK.

Design

Participants were randomly allocated to the dietary intervention (DIET, n = 50) or control (CON, n = 49). The DIET group were asked to follow a Mediterranean type diet for 16 weeks whereas the CON group were asked to follow their normal diet.

Measurements

All participants completed an Arthritis Impact Measurement Scale (AIMS2) pre-, mid- and post- study period. A subset of participants attended a clinic at the start and end of the study for assessment of joint range of motion, ROM (DIET = 33, CON = 28), and to provide blood samples (DIET = 29, CON = 25) for biomarker analysis (including serum cartilage oligomeric matrix protein (sCOMP) (a marker of cartilage degradation) and a panel of other relevant biomarkers including pro- and anti-inflammatory cytokines).

Results

There were no differences between groups in the response of any AIMS2 components and most biomarkers (p > 0.05), except the pro-inflammatory cytokine IL-1α, which decreased in the DIET group (~47%, p = 0.010). sCOMP decreased in the DIET group by 1 U/L (~8%, p = 0.014). There was a significant improvement in knee flexion and hip rotation ROM in the DIET group (p < 0.05).

Conclusions

The average reduction in sCOMP in the DIET group (1 U/L) represents a meaningful change, but the longer term effects require further study.
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Metadaten
Titel
Effect of a Mediterranean type diet on inflammatory and cartilage degradation biomarkers in patients with osteoarthritis
verfasst von
J. Dyer
G. Davison
S. M. Marcora
Alexis R. Mauger
Publikationsdatum
28.09.2016
Verlag
Springer Paris
Erschienen in
The journal of nutrition, health & aging / Ausgabe 5/2017
Print ISSN: 1279-7707
Elektronische ISSN: 1760-4788
DOI
https://doi.org/10.1007/s12603-016-0806-y

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