Open Access
28.09.2016
Effect of a Mediterranean type diet on inflammatory and cartilage degradation biomarkers in patients with osteoarthritis
verfasst von:
J. Dyer, G. Davison, S. M. Marcora, Alexis R. Mauger
Erschienen in:
The journal of nutrition, health & aging
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Ausgabe 5/2017
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Abstract
Objectives
To investigate the effects of a Mediterranean type diet on patients with osteoarthritis (OA).
Participants
Ninety-nine volunteers with OA (aged 31 - 90 years) completed the study (83% female).
Setting
Southeast of England, UK.
Design
Participants were randomly allocated to the dietary intervention (DIET, n = 50) or control (CON, n = 49). The DIET group were asked to follow a Mediterranean type diet for 16 weeks whereas the CON group were asked to follow their normal diet.
Measurements
All participants completed an Arthritis Impact Measurement Scale (AIMS2) pre-, mid- and post- study period. A subset of participants attended a clinic at the start and end of the study for assessment of joint range of motion, ROM (DIET = 33, CON = 28), and to provide blood samples (DIET = 29, CON = 25) for biomarker analysis (including serum cartilage oligomeric matrix protein (sCOMP) (a marker of cartilage degradation) and a panel of other relevant biomarkers including pro- and anti-inflammatory cytokines).
Results
There were no differences between groups in the response of any AIMS2 components and most biomarkers (p > 0.05), except the pro-inflammatory cytokine IL-1α, which decreased in the DIET group (~47%, p = 0.010). sCOMP decreased in the DIET group by 1 U/L (~8%, p = 0.014). There was a significant improvement in knee flexion and hip rotation ROM in the DIET group (p < 0.05).
Conclusions
The average reduction in sCOMP in the DIET group (1 U/L) represents a meaningful change, but the longer term effects require further study.