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Erschienen in: Journal of Neurology 11/2018

01.09.2018 | Original Communication

Effect of anti-seizure drugs on serum S100B in patients with focal seizure: a randomized controlled trial

verfasst von: Rituparna Maiti, Biswa Ranjan Mishra, Monalisa Jena, Archana Mishra, Santanu Nath, Anand Srinivasan

Erschienen in: Journal of Neurology | Ausgabe 11/2018

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Abstract

Purpose

S100B, a cytokine produced by astrocytes, has been studied as a biomarker of glial and neuronal damage in epilepsy. The present study investigated the reliability of serum S100B as a biomarker and the effect of carbamazepine and oxcarbazepine on serum S100B in patients with focal seizure.

Methods

The present randomized, open-label, active-controlled, parallel design clinical trial (NCT02705768) conducted on 60 patients with focal seizure. After recruitment, clinical evaluations were performed including Chalfont-National Hospital seizure severity scale (NHS3), Quality of Life in Epilepsy Inventory (QOLIE-31) and serum S100B was estimated. Thirty healthy individuals were recruited for evaluation of serum S100B at baseline only. After randomization, the study groups received either tablet oxcarbazepine or tablet carbamazepine. At follow-up after 2 weeks, clinical status was checked and at 4 weeks, NHS3 and QOLIE-31 were scored along with serum S100B level estimation.

Results

Serum S100B level in patients with focal seizure increased significantly in comparison to healthy volunteers. The decrease in serum S100B was significantly higher with carbamazepine group (0.004; 95% CI 0.001–0.006; p = 0.01) over oxcarbazepine group. In logistic regression analysis, there was an increase in the log odds of 0.17 for focal seizure positivity against healthy controls if S100B level increases by 1 pg and area under curve obtained by ROC analysis was 0.96 (p < 0.001).

Conclusion

Serum S100B increases in the patients with focal seizure and therapy with carbamazepine can decrease serum S100B level significantly over oxcarbazepine. Serum S100B can be used as a prognostic biomarker in a focal seizure.
Literatur
3.
Zurück zum Zitat Donato R (2001) S100: a multigenic family of calcium-modulated proteins of the EF-hand type with intracellular and extracellular functional roles. Int J Biochem Cell Biol 33(7):637–668CrossRef Donato R (2001) S100: a multigenic family of calcium-modulated proteins of the EF-hand type with intracellular and extracellular functional roles. Int J Biochem Cell Biol 33(7):637–668CrossRef
4.
Zurück zum Zitat Herrmann M, Vos P, Wunderlich MT, de Bruijn CH, Lamers KJ (2000) Release of glial tissue-specific proteins after acute stroke: a comparative analysis of serum concentrations of protein S-100B and glial fibrillary acidic protein. Stroke 31(11):2670–2677CrossRef Herrmann M, Vos P, Wunderlich MT, de Bruijn CH, Lamers KJ (2000) Release of glial tissue-specific proteins after acute stroke: a comparative analysis of serum concentrations of protein S-100B and glial fibrillary acidic protein. Stroke 31(11):2670–2677CrossRef
5.
8.
13.
Zurück zum Zitat Steinhoff BJ, Tumani H, Otto M, Mursch K, Wiltfang J, Herrendorf G, Bittermann HJ, Felgenhauer K, Paulus W, Markakis E (1999) Cisternal S100 protein and neuron-specific enolase are elevated and site-specific markers in intractable temporal lobe epilepsy. Epilepsy Res 36(1):75–82CrossRef Steinhoff BJ, Tumani H, Otto M, Mursch K, Wiltfang J, Herrendorf G, Bittermann HJ, Felgenhauer K, Paulus W, Markakis E (1999) Cisternal S100 protein and neuron-specific enolase are elevated and site-specific markers in intractable temporal lobe epilepsy. Epilepsy Res 36(1):75–82CrossRef
14.
Zurück zum Zitat Kacinski M, Budziszewska B, Lason W, Zajac A, Skowronek-Bala B, Leskiewicz M, Kubik A, Basta-Kaim A (2012) Level of S100B protein, neuron specific enolase, orexin A, adiponectin and insulin-like growth factor in serum of pediatric patients suffering from sleep disorders with or without epilepsy. Pharmacol Rep PR 64(6):1427–1433CrossRef Kacinski M, Budziszewska B, Lason W, Zajac A, Skowronek-Bala B, Leskiewicz M, Kubik A, Basta-Kaim A (2012) Level of S100B protein, neuron specific enolase, orexin A, adiponectin and insulin-like growth factor in serum of pediatric patients suffering from sleep disorders with or without epilepsy. Pharmacol Rep PR 64(6):1427–1433CrossRef
18.
Zurück zum Zitat Leutmezer F, Wagner O, Baumgartner C (2002) Serum s-100 protein is not a suitable seizure marker in temporal lobe epilepsy. Epilepsia 43(10):1172–1174CrossRef Leutmezer F, Wagner O, Baumgartner C (2002) Serum s-100 protein is not a suitable seizure marker in temporal lobe epilepsy. Epilepsia 43(10):1172–1174CrossRef
19.
Zurück zum Zitat Portela LV, Tort AB, Walz R, Bianchin M, Trevisol-Bittencourt PC, Wille PR, Cardoso RC, Ishida MM, vonWangenheim A, Grisard EC, Steindel M, Goncalves CA, Souza DO (2003) Interictal serum S100B levels in chronic neurocysticercosis and idiopathic epilepsy. Acta Neurol Scand 108(6):424–427CrossRef Portela LV, Tort AB, Walz R, Bianchin M, Trevisol-Bittencourt PC, Wille PR, Cardoso RC, Ishida MM, vonWangenheim A, Grisard EC, Steindel M, Goncalves CA, Souza DO (2003) Interictal serum S100B levels in chronic neurocysticercosis and idiopathic epilepsy. Acta Neurol Scand 108(6):424–427CrossRef
20.
Zurück zum Zitat Berg AT, Berkovic SF, Brodie MJ, Buchhalter J, Cross JH, van Emde Boas W, Engel J, French J, Glauser TA, Mathern GW, Moshe SL, Nordli D, Plouin P, Scheffer IE (2010) Revised terminology and concepts for organization of seizures and epilepsies: report of the ILAE Commission on Classification and Terminology, 2005–2009. Epilepsia 51(4):676–685. https://doi.org/10.1111/j.1528-1167.2010.02522.x CrossRefPubMed Berg AT, Berkovic SF, Brodie MJ, Buchhalter J, Cross JH, van Emde Boas W, Engel J, French J, Glauser TA, Mathern GW, Moshe SL, Nordli D, Plouin P, Scheffer IE (2010) Revised terminology and concepts for organization of seizures and epilepsies: report of the ILAE Commission on Classification and Terminology, 2005–2009. Epilepsia 51(4):676–685. https://​doi.​org/​10.​1111/​j.​1528-1167.​2010.​02522.​x CrossRefPubMed
21.
Zurück zum Zitat Duncan JS, Sander JW (1991) The chalfont seizure severity scale. J Neurol Neurosurg Psychiatry 54(10):873–876CrossRef Duncan JS, Sander JW (1991) The chalfont seizure severity scale. J Neurol Neurosurg Psychiatry 54(10):873–876CrossRef
22.
Zurück zum Zitat Cramer JA, French J (2001) Quantitative assessment of seizure severity for clinical trials: a review of approaches to seizure components. Epilepsia 42(1):119–129CrossRef Cramer JA, French J (2001) Quantitative assessment of seizure severity for clinical trials: a review of approaches to seizure components. Epilepsia 42(1):119–129CrossRef
23.
Zurück zum Zitat Cramer JA, Perrine K, Devinsky O, Bryant-Comstock L, Meador K, Hermann B (1998) Development and cross-cultural translations of a 31-item quality of life in epilepsy inventory. Epilepsia 39(1):81–88CrossRef Cramer JA, Perrine K, Devinsky O, Bryant-Comstock L, Meador K, Hermann B (1998) Development and cross-cultural translations of a 31-item quality of life in epilepsy inventory. Epilepsia 39(1):81–88CrossRef
25.
Zurück zum Zitat Khurgel M, Ivy GO (1996) Astrocytes in kindling: relevance to epileptogenesis. Epilepsy Res 26(1):163–175CrossRef Khurgel M, Ivy GO (1996) Astrocytes in kindling: relevance to epileptogenesis. Epilepsy Res 26(1):163–175CrossRef
26.
Zurück zum Zitat Jankowsky JL, Patterson PH (2001) The role of cytokines and growth factors in seizures and their sequelae. Prog Neurobiol 63(2):125–149CrossRef Jankowsky JL, Patterson PH (2001) The role of cytokines and growth factors in seizures and their sequelae. Prog Neurobiol 63(2):125–149CrossRef
27.
Zurück zum Zitat Donato R (1999) Functional roles of S100 proteins, calcium-binding proteins of the EF-hand type. Biochimica et Biophysica Acta 1450(3):191–231CrossRef Donato R (1999) Functional roles of S100 proteins, calcium-binding proteins of the EF-hand type. Biochimica et Biophysica Acta 1450(3):191–231CrossRef
28.
Zurück zum Zitat Goncalves DS, Lenz G, Karl J, Goncalves CA, Rodnight R (2000) Extracellular S100B protein modulates ERK in astrocyte cultures. Neuroreport 11(4):807–809CrossRef Goncalves DS, Lenz G, Karl J, Goncalves CA, Rodnight R (2000) Extracellular S100B protein modulates ERK in astrocyte cultures. Neuroreport 11(4):807–809CrossRef
29.
Zurück zum Zitat Wong CH, Rooney SJ, Bonser RS (1999) S-100beta release in hypothermic circulatory arrest and coronary artery surgery. Ann Thorac Surg 67(6):1911–1914 (discussion 1919–1921) CrossRef Wong CH, Rooney SJ, Bonser RS (1999) S-100beta release in hypothermic circulatory arrest and coronary artery surgery. Ann Thorac Surg 67(6):1911–1914 (discussion 1919–1921) CrossRef
32.
Zurück zum Zitat Wolfson M, Bersudsky Y, Zinger E, Simkin M, Belmaker RH, Hertz L (2000) Chronic treatment of human astrocytoma cells with lithium, carbamazepine or valproic acid decreases inositol uptake at high inositol concentrations but increases it at low inositol concentrations. Brain Res 855(1):158–161CrossRef Wolfson M, Bersudsky Y, Zinger E, Simkin M, Belmaker RH, Hertz L (2000) Chronic treatment of human astrocytoma cells with lithium, carbamazepine or valproic acid decreases inositol uptake at high inositol concentrations but increases it at low inositol concentrations. Brain Res 855(1):158–161CrossRef
Metadaten
Titel
Effect of anti-seizure drugs on serum S100B in patients with focal seizure: a randomized controlled trial
verfasst von
Rituparna Maiti
Biswa Ranjan Mishra
Monalisa Jena
Archana Mishra
Santanu Nath
Anand Srinivasan
Publikationsdatum
01.09.2018
Verlag
Springer Berlin Heidelberg
Erschienen in
Journal of Neurology / Ausgabe 11/2018
Print ISSN: 0340-5354
Elektronische ISSN: 1432-1459
DOI
https://doi.org/10.1007/s00415-018-9026-1

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