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16.05.2019 | Review Article

Effect of Bariatric Surgery on Serum Inflammatory Factors of Obese Patients: a Systematic Review and Meta-Analysis

Zeitschrift:
Obesity Surgery
Autoren:
Moein Askarpour, Dana Khani, Ali Sheikhi, Ehsan Ghaedi, Shahab Alizadeh
Wichtige Hinweise

Electronic supplementary material

The online version of this article (https://​doi.​org/​10.​1007/​s11695-019-03926-0) contains supplementary material, which is available to authorized users.

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Abstract

Obesity is one of the main causes of inflammation. Previous studies have reported inconclusive results regarding the effect of bariatric surgery on inflammatory markers. This systematic review and meta-analysis is aimed at describing the effect of bariatric surgery on C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α). PubMed/Medline and Scopus were systematically searched for all eligible studies from inception to June 2018. Results are expressed as weighted mean difference (MD) with 95% confidence intervals (CI) using a random effects model. Overall, 116 studies which evaluated serum CRP, IL-6, and TNF-α after bariatric surgery were included. Pooled effect size showed significant reduction in serum CRP (− 5.30 mg/l, 95% CI − 5.46, − 5.15, P < 0.001), IL-6 (− 0.58 pg/ml, 95% CI − 0.64, − 0.53, P < 0.001), and TNF-α (− 0.20 pg/ml, 95% CI − 0.39, − 0.02, P = 0.031) with significant heterogeneity across studies (> 95% for all factors). Bariatric surgery significantly lowered inflammatory factors; however, baseline BMI, follow-up duration and type of surgery could impact the extent of observed effects.

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Zusatzmaterial
Supplemental Fig. 1 (PDF 14 kb)
11695_2019_3926_MOESM1_ESM.pdf
Supplemental Fig. 2 (PDF 8 kb)
11695_2019_3926_MOESM2_ESM.pdf
High Resolution Image (TIFF 153 kb)
11695_2019_3926_MOESM3_ESM.tiff
Supplemental Fig. 4 (DOCX 141 kb)
11695_2019_3926_MOESM4_ESM.docx
Supplemental Fig. 5 (DOCX 138 kb)
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Supplemental Fig. 6 (DOCX 151 kb)
11695_2019_3926_MOESM6_ESM.docx
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