Background
Methods
Participants
Recipients (n)
|
Mean ± SD or %
| |
---|---|---|
Mean age [years] | 119 | 47.32 ± 14.03 |
Sex | 119 | 53.8 M% |
BMI [kg/m2] | 67 | 25.75 ± 4.50 |
AH | 115 | 79.13% |
HD before Tx | 84 | 78.6 % |
Preemptive Tx | 84 | 4.76% |
Mean time of D before Tx [months] | 80 | 28.02 ± 19.65 |
CIT [hours] | 93 | 17.7 ± 6.65 |
DGF frequency | 119 | 30.25% |
AR frequency | 119 | 28.57% |
CAD frequency | 119 | 14.29% |
Mortality | 119 | 2.52% |
Relative telomere length analysis
Statistical analysis
Results
Correlation of the relative telomere biopsy length
|
N
|
Rs
|
p value
|
---|---|---|---|
Recipients’ age & RTL 6 months | 12 | +0.58 |
0.049
|
Donors’ age & RTL 12–24 months | 43 | −0.36 |
0.017
|
Donors’ age & RTL 12–60 months | 53 | −0.28 |
0.045
|
Duration of dialysis before Tx & RTL 24 months | 9 | −0.74 |
0.024
|
Duration of dialysis before Tx & RTL 18–60 months | 17 | −0.47 |
0.05
|
PRA & RTL 6 months | 8 | −0.73 |
0.04
|
Creatinine 12 months & RTL 0 months | 17 | −0.60 |
0.01
|
Creatinine 12–18 months & RTL 0 months | 17 | −0.61 |
0.009
|
Creatinine 18 months & RTL 0–6 months | 24 | −0.54 |
0.006
|
Biopsy [months]
|
Patients with DGF
|
Patients without DGF
|
p value
| ||
---|---|---|---|---|---|
Relative telomere length
|
Relative telomere length
| ||||
N
|
Mean ± SD
|
N
|
Mean ± SD
| ||
Biopsy 0-3 | 15 | 234.2 ± 108.8 | 47 | 287.2 ± 146.0 | 0.25 |
Biopsy 3-6 | 9 | 181.8 ± 82.0 | 30 | 284.6 ± 149.6 |
<0.05
|
Biopsy 12-24 | 11 | 199.1 ± 105.8 | 34 | 278.8 ± 167.2 | 0.18 |
Biopsy 18-60 | 9 | 193.1 ± 105.3 | 25 | 246.4 ± 161.4 | 0.56 |
Biopsy [months]
|
Patients with AR
|
Patients without AR
|
p value
| ||
---|---|---|---|---|---|
Relative telomere length
|
Relative telomere length
| ||||
N
|
Mean ± SD
|
N
|
Mean ± SD
| ||
Biopsy 0-3 | 10 | 270.8 ± 151.6 | 52 | 275.0 ± 138.0 | 0.99 |
Biopsy 3-6 | 8 | 253.2 ± 184.4 | 31 | 262.9 ± 133.8 | 0.64 |
Biopsy 12-24 | 18 | 241.7 ± 163.7 | 27 | 271.1 ± 154.7 | 0.44 |
Biopsy 18-60 | 14 | 188.1 ± 162.1 | 20 | 263.3 ± 134.7 |
0.047
|
Biopsy [months]
|
Patients with CAD
|
Patients without CAD
|
p value
| ||
---|---|---|---|---|---|
Relative telomere length
|
Relative telomere length
| ||||
N
|
Mean ± SD
|
N
|
Mean ± SD
| ||
Biopsy 0-3 | 5 | 343.5 ± 79.6 | 57 | 268.3 ± 141.9 | 0.15 |
Biopsy 3-6 | 4 | 336.5 ± 91.4 | 35 | 252.3 ± 146.0 | 0.15 |
Biopsy 12-24 | 9 | 168.0 ± 120.0 | 36 | 282.1 ± 158.4 |
0.038
|
Biopsy 18-60 | 10 | 178.7 ± 132.8 | 24 | 254.6 ± 152.3 | 0.16 |
Risk factor
|
RTL 3–6 months
|
RTL 12–60 months
|
RTL 18–60 months
|
---|---|---|---|
p value
|
p value
|
p value
| |
DGF | 0.089 * | NS | NS |
AR | NS | NS |
0.048* |
CAD | NS |
0.02 * | NS |