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06.10.2018 | Review | Ausgabe 8/2018

Clinical Oral Investigations 8/2018

Effect of EDTA root conditioning on the outcome of coronally advanced flap with connective tissue graft: a systematic review and meta-analysis

Zeitschrift:
Clinical Oral Investigations > Ausgabe 8/2018
Autoren:
Shayan Barootchi, Lorenzo Tavelli, Andrea Ravidà, Chin-Wei Wang, Hom-Lay Wang
Wichtige Hinweise

Electronic supplementary material

The online version of this article (https://​doi.​org/​10.​1007/​s00784-018-2635-3) contains supplementary material, which is available to authorized users.

Abstract

Objectives

CAF in combination with a connective tissue graft (CTG) is considered the technique of choice for treating gingival recessions (GRs). Among the many recognized factors that can affect the outcomes, the use of chemical agents has been proposed. The effect of EDTA, as a commonly used agent, remains controversial. Therefore, the aim of this review was to assess the efficacy of EDTA root conditioning when combined to CAF + CTG.

Material and methods

A literature search was conducted to identify randomized clinical trials (RCTs) that performed CAF + CTG with and without EDTA for root coverage procedures. The following outcomes were assessed: recession reduction (Rec Red), complete root coverage (CRC), keratinized tissue gain (KT gain), clinical attachment level changes (CAL gain), and changes in pocket depth (PD changes).

Results

Fourteen RCTs (575 GRs) were included and analyzed. Six articles were included in the EDTA group, with 8 in the non-EDTA group. Meta-analyses revealed statistically significant differences for the outcomes of Rec Red (3.68 mm versus 3.07 mm), CAL gain (4.15 mm versus 3.07 mm), and PD changes (− 0.44 mm versus 0.27 mm) in favor of the EDTA group, while outcomes of CRC (odds ratio of 1.15) and KT gain (1.98 mm versus 1.62 mm) were not significantly different.

Conclusions

Limited evidence is available when evaluating the effectiveness of EDTA root conditioning with CAF + CTG. However, the adjunct application of EDTA with CAF + CTG appears to be beneficial.

Clinical relevance

The adjunct application of EDTA may provide benefits when performing root coverage procedure via CAF + CTG.

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Zusatzmaterial
Data S1 Characteristics and references of the excluded articles. (DOCX 14 kb)
784_2018_2635_MOESM1_ESM.docx
Data S2 Bias risk assessment for the included RCTs using The Cochrane Risk of Bias Tool for Randomized Controlled Trials (DOCX 16 kb)
784_2018_2635_MOESM2_ESM.docx
High resolution image (TIF 2398 kb)
784_2018_2635_MOESM3_ESM.tif
High resolution image (TIF 2245 kb)
784_2018_2635_MOESM4_ESM.tif
High resolution image (TIF 5958 kb)
784_2018_2635_MOESM5_ESM.tif
Literatur
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