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Erschienen in: Drugs & Aging 11/2018

13.10.2018 | Original Research Article

Effect of Exercise on Drug-Related Falls Among Persons with Alzheimer's Disease: A Secondary Analysis of the FINALEX Study

verfasst von: Niko M. Perttila, Hanna Öhman, Timo E. Strandberg, Hannu Kautiainen, Minna Raivio, Marja-Liisa Laakkonen, Niina Savikko, Reijo S. Tilvis, Kaisu H. Pitkälä

Erschienen in: Drugs & Aging | Ausgabe 11/2018

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Abstract

Introduction

No study has investigated how exercise modifies the effect of fall-related drugs (FRDs) on falls among people with Alzheimer’s disease (AD).

Objective

The aim of this study was to investigate how exercise intervention and FRDs interact with fall risk among patients with AD.

Methods

In the FINALEX trial, community-dwelling persons with AD received either home-based or group-based exercise twice weekly for 1 year (n =129); the control group received normal care (n =65). The number of falls was based on spouses’ fall diaries. We examined the incidence rate ratios (IRRs) for falls among both non-users and users of various FRDs (antihypertensives, psychotropics, drugs with anticholinergic properties [DAPs]) in both control and combined intervention groups.

Results

Between the intervention and control groups, there was no difference in the number of falls among those without antihypertensives or psychotropics. In the intervention group taking antihypertensives, the IRR was 0.5 falls/person-year (95% confidence interval [CI] 0.4–0.6), while in the control group, the IRR was 1.5 falls/person-year (95% CI 1.2–1.8) [p < 0.001 for group, p = 0.067 for medication, p < 0.001 for interaction]. Among patients using psychotropics, the intervention group had an IRR of 0.7 falls/person-year (95% CI 0.6–0.9), while the control group had an IRR of 2.0 falls/person-year (95% CI 1.6–2.5) [p < 0.001 for group, p = 0.071 for medication, p < 0.001 for interaction]. There was a significant difference in falls between the intervention and control groups not using DAPs (0.6, 95% CI 0.5–0.7; 1.2, 95% CI 1.0–1.4), and between the intervention and control groups using DAPs (1.1, 95% CI 0.8–1.3; 1.5, 95% CI 1.0–2.1) [p < 0.001 for group, p = 0.014 for medication, p  = 0.97 for interaction].

Conclusion

Exercise has the potential to decrease the risk for falls among people with AD using antihypertensives and psychotropics.

Trial Registration

ACTRN12608000037303.
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Metadaten
Titel
Effect of Exercise on Drug-Related Falls Among Persons with Alzheimer's Disease: A Secondary Analysis of the FINALEX Study
verfasst von
Niko M. Perttila
Hanna Öhman
Timo E. Strandberg
Hannu Kautiainen
Minna Raivio
Marja-Liisa Laakkonen
Niina Savikko
Reijo S. Tilvis
Kaisu H. Pitkälä
Publikationsdatum
13.10.2018
Verlag
Springer International Publishing
Erschienen in
Drugs & Aging / Ausgabe 11/2018
Print ISSN: 1170-229X
Elektronische ISSN: 1179-1969
DOI
https://doi.org/10.1007/s40266-018-0594-7

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