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Erschienen in: Supportive Care in Cancer 4/2015

01.04.2015 | Original Article

Effect of exercise therapy on muscle mass and physical functioning in patients undergoing allogeneic hematopoietic stem cell transplantation

verfasst von: Takahiro Takekiyo, Koichiro Dozono, Takayuki Mitsuishi, Yoshihiro Murayama, Ayako Maeda, Nobuaki Nakano, Ayumu Kubota, Masahito Tokunaga, Shogo Takeuchi, Yoshifusa Takatsuka, Atae Utsunomiya

Erschienen in: Supportive Care in Cancer | Ausgabe 4/2015

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Abstract

Purpose

Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is associated with transplant-related toxicities, which may have a profound impact on a patient’s physical functioning and body composition. In order to analyze the effect of exercise therapy on muscle mass and physical functioning in patients receiving allo-HSCT, we measured muscle mass and physical functioning before and after allo-HSCT.

Methods

Eighty-six patients who had undergone allo-HSCT between February 2010 and September 2013 at Imamura Bun-in Hospital participated in this study. Physical therapists performed exercise therapy with patients 5 days a week, starting 2 weeks before allo-HSCT. Body composition, 6-min walk test (6MWT) scores, and handgrip strength were evaluated 2 weeks before allo-HSCT and 6 weeks after allo-HSCT.

Results

Thirty-five patients were available for evaluation 2 weeks before and 6 weeks after allo-HSCT. The 6MWT (p = 0.005) and handgrip strength (p < 0.001) significantly decreased after allo-HSCT. Although upper extremity muscle mass (p = 0.001) and trunk muscle mass (p < 0.001) significantly decreased after allo-HSCT, lower extremity muscle mass remained unchanged.

Conclusions

In this study, it is suggested that exercise therapy may be effective for maintaining lower extremity muscle mass in patients undergoing allo-HSCT.
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Metadaten
Titel
Effect of exercise therapy on muscle mass and physical functioning in patients undergoing allogeneic hematopoietic stem cell transplantation
verfasst von
Takahiro Takekiyo
Koichiro Dozono
Takayuki Mitsuishi
Yoshihiro Murayama
Ayako Maeda
Nobuaki Nakano
Ayumu Kubota
Masahito Tokunaga
Shogo Takeuchi
Yoshifusa Takatsuka
Atae Utsunomiya
Publikationsdatum
01.04.2015
Verlag
Springer Berlin Heidelberg
Erschienen in
Supportive Care in Cancer / Ausgabe 4/2015
Print ISSN: 0941-4355
Elektronische ISSN: 1433-7339
DOI
https://doi.org/10.1007/s00520-014-2425-7

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