Introduction
Method
Search strategy
(("Coronavirus"[MeSH Terms] or "COVID-19" [MeSH Terms] or "Deltacoronavirus"[MeSH Terms] or "Deltacoronavirus"[MeSH Terms] or "Munia coronavirus HKU13"[TIAB] or "Middle East Respiratory Syndrome Coronavirus"[MeSH Terms] or "MERS-COV-2"[TIAB] or "MERS Virus"[TIAB] or "MERS Viruses"[tiab] or "Virus, MERS"[tiab] or "Viruses, MERS"[tiab] or "Coronavirus NL63, Human"[MeSH Terms] or "HCoV-NL63"[tiab] or "Human Coronavirus NL63"[tiab] or "Coronavirus NL63, Human"[tiab] or "Coronavirus Infections"[MeSH Terms] or "Coronavirus Infection*"[tiab] or "Coronavirus*"[tiab] or "SARS Virus"[MeSH Terms] or "Severe Acute Respiratory Syndrome Virus"[tiab] or "SARS-Related Coronavirus"[tiab] or "SARS-CoV"[tiab] or "SARS Coronavirus"[tiab] or "Coronavirus, SARS-Associated"[tiab] or "Alphacoronavirus"[MeSH Terms] or "Alphacoronavirus*"[tiab] or "Rhinolophus bat coronavirus HKU2"[tiab] or "Miniopterus bat coronavirus HKU8"[tiab] or "2019 novel coronavirus infection"[tiab] or "coronavirus disease 2019"[tiab] or "coronavirus disease-19"[tiab] or "2019-nCoV disease"[tiab] or "2019 novel coronavirus disease"[tiab] or "2019-nCoV infection"[tiab] or "Coronavirus 229E, Human"[tiab] or "HCoV-229E"[tiab] or "Human Coronavirus 229E"[tiab] or "Betacoronavirus"[tiab] or "Betacoronaviruses"[tiab] or "Pipistrellus bat coronavirus HKU5"[tiab] or "Human coronavirus HKU1"[tiab] or "HCoV-HKU1 "[tiab] or "Rousettus bat coronavirus HKU9"[tiab] or "Betacoronavirus1"[tiab] or "Human enteric coronavirus"[tiab] or "Human enteric coronaviruses"[tiab] or "Coronaviruses"[tiab] or "Deltacoronavirus*"[tiab] or "Coronavirus Infections"[tiab] or "Coronavirus Infection"[tiab] or "Infection, Coronavirus"[tiab] or "Infections, Coronavirus"[tiab] or "Middle East Respiratory Syndrome"[tiab] or "SARS Virus"[tiab] or "SARS Related Coronavirus"[tiab] or "Coronavirus, SARS"[tiab] or "Severe acute respiratory syndrome-related coronavirus"[tiab] or "Coronavirus, SARS-Associated"[tiab] or "SARS Associated Coronavirus"[tiab] or "Alphacoronavirus*"[tiab] or "COVID19"[tiab] or "2019 novel coronavirus infection"[tiab] or "2019 novel coronavirus disease"[tiab] or "Betacoronaviruses"[tiab] or "Betacoronavirus 1 "[tiab] or "Human enteric coronavirus*"[tiab]) AND ("Plants"[MeSH Terms] or "Plant Mucilage"[MeSH Terms] or "Plant Gums"[MeSH Terms] or "Plant Exudates"[MeSH Terms] or "Plant Lectins"[MeSH Terms] or "Plant Oils"[MeSH Terms] or "Plant Proteins"[MeSH Terms] or "Resins, Plant"[MeSH Terms] or "Plant Extracts"[MeSH Terms] or "Flowers"[MeSH Terms] or "Plants, Medicinal"[MeSH Terms] or "Plant*" [TIAB] or "Plant Mucilage"[tiab] or "Plant Gums"[tiab] or "Plant Exudates"[tiab] or "Plant Lectins"[tiab] or "Plant Oils"[tiab] or "Plant Proteins"[tiab] or "Resins, Plant"[tiab] or "Plant Extracts"[tiab] or "Flowers"[tiab] or "Plants, Medicinal"[tiab] or "Medicinal Plant"[tiab] or "Plant, Medicinal"[tiab] or "Pharmaceutical Plant*"[tiab] or "Plant, Pharmaceutical"[tiab] or "Plants, Pharmaceutical"[tiab] or "Healing Plants"[tiab] or "Healing Plant"[tiab] or "Plant, Healing"[tiab] or "Medicinal Herbs"[tiab] or "Herb, Medicinal"[tiab] or "Medicinal Herb"[tiab] or "Herbs, Medicinal"[tiab] or "herbal medicine"[tiab] or "Leave, Plant"[tiab] or "Plant Leave*"[tiab] or "Plant Leaf"[tiab] or "Leaf, Plant"[tiab])) |
Inclusion and exclusion criteria
Outcomes
Quality control
Meta-analysis
Results
Applying exclusion criteria
Characteristics of included studies
Ref | Virus strain/host | Drug name/plant | Main outcomes | exposure time/hours | SI(CC50/IC50) | EC50 | |
---|---|---|---|---|---|---|---|
[37] | MERS-COV-2/MRC-5 | Silvestrol/ Meliaceae | SI, Virus titer | 24 h | > 7690 | 0.0013 µM/L | |
HCoV-229E/ MRC-5 | > 3330 | 0.003 µM/L | |||||
HCoV-229E/ PBMCs | > 350 | 0.0028 µM/L | |||||
HCoV-229E/ Huh-7 | > 0.75 | 0.040 µM/L | |||||
[9] | HCoV-229E/ MRC-5 | Saikosaponins B2/ Bupleurum | SI, EC50, Virus inhibition | 96 h | 221.9 | 1.7 ± 0.1 µM/L | |
Saikosaponin A/ Bupleurum | 26.6 | 8.6 ± 0.3 µM/L | |||||
Saikosaponin C/ Bupleurum | 19.2 | 19.9 ± 0.1 µM/L | |||||
Saikosaponin D/ Bupleurum | 13.3 | 13.2 ± 0.3 µM/L | |||||
[7] | SARS-COV strain FFM 1/ African green monkey kidney cell lines Vero | Extract/Yin-Chiau-San | SI, EC50 | 72 h | > 1 | > 500(µg/ml) | |
Extract/ Pu-Zhi-Siau-Du-Yien | > 2 | 240(µg/ml) | |||||
Extract/ Ger-Gern-Hwang-Lein | > 3 | 134(µg/ml) | |||||
Extract/ Sang-Zhiu-Yien | > 1 | 349(µg/ml) | |||||
Extract/ Huang-Lein-Zhei-Du-Tang | > 1 | 369(µg/ml) | |||||
Extract/ Toona sinensis leaves | 17 | 30(µg/ml) | |||||
Extract/ Toona sinensis leaves | > 13 | 37 (µg/ml) | |||||
Extract /Amaryllidaceae | 370 | 2.4 (± 0.2) (µg/ml) | |||||
[25] | SARS-COV (BJ-001)/ Vero E6 cells | Artemisia annua | SI, EC50, Virus inhibition, | 72 h | 31 | 34.5(± 2.6) (µg/ml) | |
Pyrrosia
lingua | 55 | 43.2(± 14.1) (µg/ml) | |||||
Lindera aggregate | 16 | 88.2(± 7.7) (µg/ml) | |||||
SARS-COV (BJ-002)/ Vero E6 cells | Extract/ Lycoris radiata /Amaryllidaceae | 422 | 2.1 (± 0.2) (µg/ml) | ||||
Artemisia annua | 27 | 39.2 (± 4.1) (µg/ml) | |||||
Pyrrosia lingua | 59 | 40.5 (± 3.7) (µg/ml) | |||||
Lindera aggregate | 17 | 80.6 (± 5.2) (µg/ml) | |||||
[53] | HCoV-NL63/ LLC-MK2 cells, Calu-3 cells | Caffeic acid /Adoxaceae Chlorogenic acid/Adoxaceae Gallic acid/Adoxaceae | Virus inhibition, Virus titer | NR | NR | ||
[20] | SARS-COV / Vero E6 cells | Lectin (Man-specific agglutinins)(APA/ Alliaceae | SI, EC50 | 72 | > 222.2 | 0.45 ± 0.08(µg/ml) | |
Mannose-specific agglutinins( HHA) | > 31.3 | 3.2 ± 2.8(µg/ml) | |||||
Mannose-specific agglutinins( GNA) | > 16.1 | 6.2 ± 0.6(µg/ml) | |||||
Mannose-specific agglutinins( NPA) | > 17.5 | 5.7 ± 4.4(µg/ml) | |||||
Mannose-specific agglutinins( LRA) | > 2.1 | 48(µg/ml) | |||||
Mannose-specific agglutinins(AUA) | > 5.5 | 18 ± 4(µg/ml) | |||||
Mannose-specific agglutinins( CA) | > 20 | 4.9 ± 0.8(µg/ml) | |||||
Mannose-specific agglutinins( LOA) | > 45.5 | 2.2 ± 1.3(µg/ml) | |||||
Mannose-specific agglutinins( EHA) | > 55.5 | 1.8 ± 0.3(µg/ml) | |||||
Mannose-specific agglutinins( TLMI) | > 2.3 | 22 ± 6(µg/ml) | |||||
Mannose-specific agglutinins( Morniga M II) | > 62.5 | 1.6 ± 0.5(µg/ml) | |||||
GlcNAc-specific agglutinins Nictaba | > 58.8 | 1.7 ± 0.3(µg/ml) | |||||
(GlcNAc)n-specific agglutinins UDA | > 76.9 | 1.3 ± 0.1(µg/ml) | |||||
Gal-specific agglutinins Morniga G II | > 2 | 50 ± 13(µg/ml) | |||||
Man/Glc-specific agglutinins Cladistris | > 13.5 | 7.4 ± 0.2(µg/ml) | |||||
Gal/GalNAc specific agglutinins -PMRIP m | > 5.5 | 18 ± 13(µg/ml) | |||||
GalNAc (> Gal) specific agglutinins/ ML III | > 12.6 | 28 ± 11(µg/ml) | |||||
GalNAcα(1,3)Gal > GalNAc > Gal-specific agglutinins/IRA | 22.7 | 2.2 ± 0.9(µg/ml) | |||||
GalNAcα(1,3)Gal > GalNAc > Gal-specific agglutinins/IRA | 8.2 | 4.4 ± 3.1(µg/ml) | |||||
GalNAcα(1,3)Gal > GalNAc > Gal-specific agglutinins/IRA | 16.2 | 3.4 ± 2.0(µg/ml) | |||||
Man/GalNAc-specific agglutinins/ TL C II | > 1.3 | 38 ± 0(µg/ml) | |||||
[22] | SARS-COV, Toronto-2 v2147/ Vero 76 | Lectin (N-acetylglucosamine)/ Urticaceae | SI, Virus titer | 72 h | 54.2 ± 52.5 | NR | |
SARS-COV, Urbani/ Vero 76 | 10.2 ± 5.6 | NR | |||||
SARS-COV, Mouse-adapted virus/ Vero 76 | 42.8 ± 47.5 | NR | |||||
SARS-COV, Frankfurt v1940/ Vero 76 | 5.5 ± 2.0 | NR | |||||
SARS-COV, Hong Kong v2157/ Vero 76 | 8.6 ± 1.1 | NR | |||||
[23] | Vero-adapted Beaudette IBV/ Vero | Ethanol extract/ Lamiaceae | SI, EC50, Virus titer | 72 h | 67.5 | 0.004 (µg/ml) | |
Vero-adapted Beaudette IBV/ Satureja montana | 17 | 0.044(µg/ml) | |||||
Vero-adapted Beaudette IBV/Origanum vulgare | 65 | 0.008(µg/ml) | |||||
Vero-adapted Beaudette IBV/Mentha piperita | 67.5 | 0.015(µg/ml) | |||||
Vero-adapted Beaudette IBV/Melissa officinalis | 39.3 | 0.010(µg/ml) | |||||
Vero-adapted Beaudette IBV/Hyssopus officinalis, | 8.4 | 0.076(µg/ml) | |||||
Vero-adapted Beaudette IBV/ Salvia officinalis, | 36.7 | 0.003(µg/ml) | |||||
17.1 | 0.017(µg/ml) | ||||||
Vero-adapted Beaudette IBV/Desmodium canadense | |||||||
[26] | SARS-COV pseudovirus/ HEK293T-ACE2 | Sanguisorba/ Rosaceae | Virus inhibition, | NR | NR | ||
[35] | HCo-229E/ Epithelial colorectal adenocarcinoma cells(Caco-2) | Extract/ Pelargonium sidoides/ Geraniaceae | SI, EC50, Virus titer | 72 h | > 2.3 | NR | |
[51] | SARS-COV / Vero E6 | Ferruginol | SI, EC50, | 72 h | 58 | 1.39 (µM) | |
Dehydroabieta-7-one | 76.3 | 4 | |||||
Sugiol | NR | n.t | |||||
Cryptojaponol | < 7.9 | > 10 | |||||
8â-hydroxyabieta-9(11),13-dien-12-one | > 510 | 1.47 | |||||
7â-hydroxydeoxycryptojaponol | 111 | 1.15 | |||||
6,7-dehydroroyleanone | 16.2 | 5.55 | |||||
3â,12-diacetoxyabieta-6,8,11,13-tetraene | 193 | 1.57 | |||||
Pinusolidic acid | 159 | 4.71 | |||||
Forskolin | 89.8 | 7.5 | |||||
Cedrane-3â,12-diol | NR | > 0 | |||||
α -cadinol | 17.3 | 4.44 | |||||
Betulinicacid | < 15 | > 10 | |||||
Betulonic acid | 180 | 0.63 | |||||
Hinokinin | NR | > 10 | |||||
Savinin | > 667 | 1.13 | |||||
4,4 ′ -O-benzoylisolaricires-inol | N.C | n.t | |||||
Honokiol | 13.7 | 6.50 | |||||
Magnolol | 18 | 3.80 | |||||
Curcumin | NR | > 10 | |||||
[52] | SARS-COV / Vero E6 | Supernatant of Cibotium barometz | SI, EC50 | 72 h | > 59.4 | 8.42 (μg/ml) | |
70% ethanol precipitated fraction of Cibotium barometz | NR | > 10(μg/ml) | |||||
Dried rhizome of Gentiana scabra | > 57.5 | 8.70(μg/ml) | |||||
The tuber of Dioscorea batatas | > 62.0 | 8.06(μg/ml) | |||||
The dried seed of Cassia tora | > 59.3 | 8.43(μg/ml) | |||||
The dried stem, with leaf of Taxillus chinensis | > 92.8 | 5.39(μg/ml) | |||||
[55] | PEDV/ Vero cells | Oleanane triterpenes2 / Theaceae | SI, EC50 | 72 h | 13.39 ± 0.67 | 1.94 ± 0.39 (µM/L) | |
Oleanane triterpenes3 / Theaceae | 5.75 ± 0.75 | 1.09 ± 0.22 (µM/L) | |||||
Oleanane triterpenes6 / Theaceae | 44.54 ± 8.34 | 0.28 ± 0.09 (µM/L) | |||||
Oleanane triterpenes7 / Theaceae | 7.99 ± 0.28 | 0.91 ± 0.07 (µM/L) | |||||
Oleanane triterpenes8 / Theaceae | 12.98 ± 2.34 | 0.06 ± 0.02 (µM/L) | |||||
Oleanane triterpenes9 / Theaceae | 32.72 ± 6.22 | 0.28 ± 0.11 (µM/L) | |||||
Oleanane triterpenes10 / Theaceae | 9.4 ± 1.04 | 2.90 ± 0.25 (µM/L) | |||||
Oleanane triterpenes11 / Theaceae | 14.75 ± 1.62 | 0.93 ± 0.22 (µM/L) | |||||
Oleanane triterpenes13 / Theaceae | 6.68 ± 0.14 | 0.34 ± 0.01 (µM/L) | |||||
Oleanane triterpenes15 / Theaceae | 6.42 ± 0.58 | 3.70 ± 0.68 (µM/L) | |||||
[56] | Porcine epidemic diarrhea virus (PEDV)/ Vero cells | Coumarins/ Saposhnikovia divaricate1/ Umbelliferae | SI, EC50 | 72 h | > 6.25 ± 0.85 | 16.25 ± 1.97 (µM/L) | |
Coumarins/ Saposhnikovia divaricate2/ Umbelliferae | > 5.85 ± 0.80 | 17.36 ± 2.12 (µM/L) | |||||
Coumarins/ Saposhnikovia divaricate3/ Umbelliferae | > 5.11 ± 0.47 | 19.70 ± 1.66 (µM/L) | |||||
Coumarins/ Saposhnikovia divaricate4/ Umbelliferae | 4.07 ± 0.25 | 3.84 ± 0.45 (µM/L) | |||||
Coumarins/ Saposhnikovia divaricate5/ Umbelliferae | > 23.90 ± 4.11 | 4.28 ± 0.64 (µM/L) | |||||
Coumarins/ Saposhnikovia divaricate6/ Umbelliferae | 7.67 ± 0.04 | 1.09 ± 0.06 (µM/L) | |||||
Coumarins/ Saposhnikovia divaricate7/ Umbelliferae | 8.21 ± 0.40 | 1.22 ± 0.09 (µM/L) | |||||
Coumarins/ Saposhnikovia divaricate8/ Umbelliferae | 7.89 ± 0.97 | 0.60 ± 0.03 (µM/L) | |||||
Coumarins/ Saposhnikovia divaricate9/ Umbelliferae | > 5.58 ± 0.41 | 18.00 ± 1.25 (µM/L) | |||||
[57] | IBV/ Vero cells | Houttuynia cordata (Saururaceae) | Virus inhibition | 1 h | NR | NR | |
Glycyrrhizinate diammonium (GD) | |||||||
IBV/ chicken embryo kidney (CEK) cells | Houttuynia cordata (Saururaceae) | ||||||
Glycyrrhizinate diammonium (GD) | |||||||
[8] | (IBV) a chicken coronavirus/ Vero cells | Rhodiola rosea, Nigella sativa, Sambucus nigra | Virus titer | 3d | NR | NR | |
[36] | MERS-COV-2 strain EMC/2012/ MRC-5 | Griffithsin (GRFT)/ Wrangeliaceae | Virus titer | 45 h | NR | NR | |
[59] | SARS-COV strain PUMC01 F5 / VeroE6 | Forsythiae Fructus | SI | 72 h | 1.4 | NR | |
Scutellariae Radix | 1.0 | NR | |||||
Astragali Radix | 1.7 | NR | |||||
Bupleuri Radix | < 1 | NR | |||||
Glycyrrhizae Radix | < 1 | NR | |||||
Cinnamomi Cortex (CCE) | 6.6 | NR | |||||
Ethanol extract of CC (Fr.1) | 5.2 | NR | |||||
Butanol fraction of CC (Fr.2) | 5.5 | NR | |||||
Aqueous fraction of CC (Fr.3) | 3.9 | NR | |||||
Ethylacetate fraction of CC (Fr.4) | 3.4 | NR | |||||
Caryophylli Flos (CFE) | 12.9 | NR | |||||
Ethanol extract of CF (Fr.1) | 5.4 | NR | |||||
Butanol fraction of CF (Fr.2) | 20.9 | NR | |||||
Aqueous fraction of CF (Fr.3) | 23.4 | NR | |||||
Ethylacetate fraction of CF (Fr.4) | 7.3 | NR | |||||
[50] | SARS-COV-2/ Vero E6 | Artemisinin(LG0019527) | Virus inhibition | 1 h | NR | NR | |
[48] | HCoV-NL63/ LCC-MK2 | Trypthantrin | Virus titer | 48 h | NR | NR | |
Indigodole B | |||||||
[6] | SARS-COV‑2/ Vero E6 cells | Arteether | SI, EC50, | 24 h | 6.42 | 31.86 ± 4.72 µM | |
Artemether | 3.13 | 73.8 ± 26.91 | |||||
Artemisicacid | 3.3 | > 100 | |||||
Artemisinin | 3.11 | 64.45 ± 2.58 | |||||
Artemisone | 4.03 | 49.64 ± 1.85 | |||||
Dihydroartemisinin | 2.38 | 13.31 ± 1.24 | |||||
Artesunate | 5.1 | 12.98 ± 5.3 | |||||
Arteannuin | 7 | 10.28 ± 1.12 | |||||
lumefantrine | 4.4 | 23.17 ± 3.22 | |||||
[46] | SARS-COV-2/ HepG2 | Andrographolide | Virus inhibition | 48 h | 2398 | NR | |
SARS-COV-2/ imHC | 1310 | NR | |||||
SARS-COV-2/ HK-2 | 1003 | NR | |||||
SARS-COV-2/ Caco-2 | 1538 | NR | |||||
SARS-COV-2/ Caco-3 | 1707 | NR | |||||
SARS-COV-2/ SH-SY5Y | 388 | NR | |||||
[40] | SARS-COV‑2/ Vero E6 | Resveratrol | EC50 | 2 h | NR | 66 µM | |
Pterostilbene | 19 µM | ||||||
[10] | SARS-COV-2/ Vero E6 | Homorringtonine | EC50 | 48 h | NR | 2.55 μM | |
Emetine | 0.46 μM | ||||||
[31] | SARS-COV-2/ Vero E6 | Phillyrin (KD-1) | Virus inhibition | 72 h | 30.66 | NR | |
HCoV-229E/ Vero E6 | 16.02 | ||||||
[32] | SARS-COV-2/ Vero E6 | Liu Shen capsule | Virus inhibition | 72 h | 8.18 | NR | |
[38] | SARS-COV/ Vero E6 | Griffithsin | SI, EC50 | 3d | > 164 | 0.61 µg/ml | |
[24] | SARS-COV-2/ Vero E6 | Corilagin (RAI-S-37) | SI, EC50 | 24 h | NR | 0.13 μmol/L | |
[45] | SARS-COV-2/ Huh-7 | EGYVIR | Virus inhibition | 3d | NR | NR | |
[11] | SARS-COV/ Vero cells | Glycyrrhizin | SI, EC50 | 72 h | > 67 | 300 µg/ml | |
[21] | HCoV-C43/ MRC-5 human lung cell | Tetrandrine | SI | 4d | 40.19 | NR | |
Fangchinoline | 11.46 | NR | |||||
Ceparanthine | 13.63 | NR | |||||
[29] | SARS-COV/ Vero | L. nobilis | SI | 48 h | 4.2 | NR | |
T. orientalis | 3.8 | NR | |||||
J. oxycredrus ssp. Oxycedrus | 3.7 | NR | |||||
Pyramidalis | 1.5 | NR | |||||
P. palaestina | > 1 | NR | |||||
S. officinalis | > 1 | NR | |||||
S. thymbra | NR | NR | |||||
Acyclovir | NR | NR | |||||
Glycyrrhizin | 1.2 | NR |
Quality control
Author/ Year | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Christin Müller/ 2017 | N | N | N | N | Y | Y | Y | Y | Y | N | N | N | Y | Y | N | N | N | Y | N | N |
Pei-Win Cheng/ 2006 | N | N | N | N | Y | Y | Y | Y | Y | Y | Y | N | Y | Y | N | N | NA | Y | N | N |
Chung-Jen Chena/2008 | N | N | N | N | Y | Y | Y | Y | Y | N | N | N | Y | Y | N | N | NA | Y | N | N |
Shi-you Li/ 2005 | N | N | N | N | Y | Y | Y | Y | Y | N | N | N | Y | Y | N | N | NA | Y | N | N |
Jing-Ru Weng/2019 | N | N | N | N | Y | Y | Y | Y | Y | Y | N | N | Y | Y | N | N | NA | Y | N | N |
Els Keyaerts/ 2007 | N | N | N | N | Y | Y | Y | Y | Y | N | N | N | Y | Y | N | N | NA | Y | N | N |
Hye-Young Kim/ 2008 | N | N | N | N | Y | Y | Y | Y | Y | N | N | N | Y | Y | N | N | N | Y | N | N |
Hye-Young Kim/ 2010 | N | N | N | N | Y | Y | Y | Y | Y | Y | N | N | Y | Y | N | N | NA | Y | N | N |
Yohichi Kumaki/ 2011 | N | N | N | N | Y | Y | Y | Y | Y | Y | Y | N | Y | Y | N | N | NA | Y | N | N |
Raimundas Lelešius/ 2019 | N | N | N | N | Y | Y | Y | Y | Y | Y | Y | N | Y | Y | N | N | NA | Y | N | N |
K.H. Chiow/ 2015 | N | N | N | N | Y | Y | Y | Y | Y | N | N | N | Y | Y | N | N | NA | Y | N | N |
Jianguo Liang/2013 | N | N | N | N | Y | Y | Y | Y | Y | N | N | N | Y | Y | N | N | NA | Y | N | N |
Martin Michaelis/ 2011 | N | N | N | N | N | Y | Y | Y | Y | N | N | N | Y | Y | N | N | NA | Y | N | N |
Chih-Chun Wen/ 2007 | N | N | N | N | Y | Y | Y | Y | Y | N | N | N | Y | Y | N | N | NA | Y | N | N |
Chih-Chun Wen/ 2011 | N | N | N | N | Y | Y | Y | Y | Y | N | N | N | Y | Y | N | Y | NA | Y | N | N |
Jun-Li Yang/2015 | N | N | N | N | Y | Y | Y | Y | Y | Y | Y | N | Y | Y | N | N | NA | Y | N | N |
Jun-Li Yang/ 2015 | N | N | N | N | Y | Y | Y | Y | Y | Y | Y | N | Y | Y | N | N | N | Y | N | N |
Jiechao Yin/2011 | N | N | N | N | Y | Y | Y | Y | Y | Y | Y | N | Y | Y | N | N | NA | Y | N | N |
Christie Chen/ 2014 | N | N | N | N | Y | Y | Y | Y | Y | N | N | N | Y | Y | N | N | NA | Y | N | N |
Aarthi Sundararajan/2010 | N | N | N | N | Y | Y | Y | Y | Y | Y | Y | N | Y | Y | N | N | NA | Y | N | N |
Jean K. Millet/ 2016 | N | N | N | N | Y | Y | Y | Y | Y | Y | Y | N | Y | Y | N | N | N | Y | N | N |
Min Zhuang/ 2009 | N | N | N | N | Y | Y | Y | Y | Y | N | N | N | Y | Y | N | N | N | Y | N | N |
Nair/2020 | N | N | N | N | Y | Y | Y | Y | Y | Y | N | N | Y | Y | N | N | NA | Y | N | N |
Tsai/ 2020 | N | N | N | N | Y | Y | Y | Y | Y | Y | Y | N | Y | Y | N | N | NA | Y | N | N |
Ruiyuan Cao/ 2020 | N | N | N | N | Y | Y | Y | Y | Y | Y | Y | N | Y | Y | N | N | N | Y | N | N |
Sa-ngiamsuntorn/ / 2020 | N | N | N | N | Y | Y | Y | Y | Y | N | N | N | Y | Y | N | N | N | Y | N | N |
Bram M. ter Ellen/2021 | N | N | N | N | Y | Y | Y | Y | Y | Y | Y | N | Y | Y | Y | N | NA | Y | N | N |
Ka-Tim Choy/2020 | N | N | N | N | Y | Y | Y | Y | Y | N | N | N | Y | Y | N | N | NA | Y | N | N |
Qinhai Ma/2020 | N | N | N | N | Y | Y | Y | Y | Y | Y | Y | N | Y | Y | N | N | N | Y | N | N |
Qinhai Ma/2020 | N | N | N | N | Y | Y | Y | Y | Y | Y | Y | N | Y | Y | N | N | NA | Y | N | N |
Barry R. O’Keefe/ 2009 | N | N | N | Y | Y | Y | Y | Y | Y | Y | Y | Y | Y | Y | N | N | NA | Y | N | N |
Quanjie LI/2020 | N | N | N | N | Y | Y | Y | Y | Y | N | N | N | Y | Y | N | N | NA | Y | N | N |
Wael H. Roshdy/ 2020 | N | N | N | N | Y | Y | Y | Y | Y | Y | Y | N | Y | Y | N | N | NA | Y | N | N |
J Cinatl/2003 | N | N | N | Y | Y | Y | Y | Y | Y | N | N | N | Y | Y | N | N | NA | Y | N | N |
Dong Eon Kim/2019 | N | N | N | N | Y | Y | Y | Y | Y | Y | Y | Y | Y | Y | N | N | NA | Y | N | N |
Monica R. Loizzo/ 2008 | N | N | N | N | Y | Y | Y | Y | Y | N | N | N | Y | Y | N | N | NA | Y | N | N |
Percentage | 0 | 0 | 0 | 0 | 97 | 100 | 100 | 100 | 100 | 90 | 52 | 5 | 100 | 100 | 2 | 0 | 0 | 100 | 0 | 0 |
Virus inhibition
Subgroup | Number of experiments | Heterogeneity (p value) | ES (95% CI) | p value |
---|---|---|---|---|
Chemical structure | ||||
Phenolic compound | 7 | 84.7% (< 0.0001) | − 7.40 (− 10.81 to − 3.97) | < 0.0001 |
Lectin | 3 | 29.4% (< 0.24) | − 18.36 (− 26.60 to − 10.88) | < 0.0001 |
Extract of plant | 4 | 84.3% (< 0.0001) | − 21.83 (− 37.83 to − 5.84) | 0.007 |
Alkaloid | 2 | 53.5% (0.143) | − 27.18 (− 48.84 to − 5.39) | 0.014 |
Peptide | 4 | 23.1%(0.27) | − 10.235(− 14.73 to − 5.74) | < 0.0001 |
Virus strain | ||||
MERS-COV-2 | 3 | 70.8% (< 0.0001) | − 10.50 (− 18.91 to − 2.10) | 0.014 |
HcoV | 8 | 79.1% (< 0.0001) | − 17.00 (− 23.36 to − 10.64) | < 0.0001 |
SARS-COV-2 | 9 | 80.3% (< 0.0001) | − 9.70 (− 14.23 to − 5.175) | < 0.0001 |
Cell line | ||||
Human | 10 | 79.5% (< 0.0001) | − 8.96 (− 12.56 to − 5.35) | < 0.0001 |
Monkey | 10 | 75.7% (< 0.0001) | − 15.22 (− 20.31 to − 10.13) | < 0.0001 |