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27.02.2019 | Original Scientific Report

Effect of High Postoperative Body Temperature on Long-Term Prognosis in Patients with Gastric Cancer After Radical Resection

Zeitschrift:
World Journal of Surgery
Autoren:
Hua-Long Zheng, Jun Lu, Ping Li, Jian-Wei Xie, Jia-Bin Wang, Jian-Xian Lin, Qi-Yue Chen, Long-Long Cao, Mi Lin, Ru-Hong Tu, Ze-Ning Huang, Ju-Li Lin, Chao-Hui Zheng, Chang-Ming Huang
Wichtige Hinweise

Electronic supplementary material

The online version of this article (https://​doi.​org/​10.​1007/​s00268-019-04965-5) contains supplementary material, which is available to authorized users.
Hua-Long Zheng and Jun Lu have contributed equally to this work and should be considered co-first authors.

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Abstract

Background

There is a lack of data on the effect of high postoperative body temperature on disease-free survival (DFS) in patients who underwent radical gastrectomy.

Methods

Patients who underwent radical gastrectomy from January 2006 to December 2011 were selected. The highest body temperature within 1 week after operation was used to establish diagnostic thresholds for high and low body temperature through X-tile software.

Results

A total of 1396 patients were included in the analysis. The diagnostic threshold for high body temperature was defined as 38 °C; 370 patients were allocated to the high-temperature group (HTG), while another 1026 patients were allocated to the low-temperature group (LTG). For all patients, survival analysis showed that 5-year DFS in the HTG was significantly lower than that for the LTG (55.6% vs 63.9%, P = 0.007). Multivariate analysis revealed that high postoperative body temperature was an independent prognostic risk factor for 5-year DFS (HR = 1.288 (1.067–1.555), P = 0.008). For patients without complications, survival analysis showed that the 5-year DFS rate in the HTG was lower than that for the LTG (57.5% vs 64.4%, P = 0.051), especially in patients with stage III gastric cancer (31.3% vs 41.7%, P = 0.037). For patients with complications or infectious complications, there were no significant differences between the HTG and LTG regarding 5-year DFS (49.3% vs 58.2%, P = 0.23 and 49.4% vs 55.1%, P = 0.481, respectively).

Conclusion

For stage III gastric cancer patients without complications, high postoperative body temperature can significantly reduce the 5-year DFS. These patients may benefit from more aggressive adjuvant therapy and postoperative surveillance regimens.

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Zusatzmaterial
Supplementary Figure 1 5-year overall survival and disease-specific survival for stage III patients with no complication. (TIFF 585 kb)
268_2019_4965_MOESM1_ESM.tif
Supplementary Figure 2 5-year disease-free survival: LTG VS HTG in patients with complications. (TIFF 787 kb)
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Supplementary Figure 3 5-year disease-free survival: LTG VS HTG in patients with infectious complications. (TIFF 779 kb)
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Supplementary material 4 (DOCX 61 kb)
268_2019_4965_MOESM4_ESM.docx
Supplementary material 5 (DOC 48 kb)
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Supplementary material 6 (DOCX 59 kb)
268_2019_4965_MOESM6_ESM.docx
Literatur
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