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Erschienen in: The Indian Journal of Pediatrics 4/2015

01.04.2015 | Original Article

Effect of Inhaled Magnesium Sulfate on Bronchial Hyperresponsiveness

verfasst von: Hui Wang, Yi Xiong, Caihui Gong, Lijuan Yin, Li Yan, Xiaoping Yuan, Sha Liu, Tiantian Shi, Jihong Dai

Erschienen in: Indian Journal of Pediatrics | Ausgabe 4/2015

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Abstract

Objectives

To determine the response of nebulized magnesium sulfate on the lung function of children with bronchial hyperresponsiveness.

Methods

Eighty-four children with asthma were divided into three groups randomly: magnesium sulfate (M), albuterol (A), and a combination of magnesium sulfate and albuterol (M + A). All patients were nebulized with acetylcholine, and then treated as designed. Lung function was compared between the three groups.

Results

Forced expiratory volume in first second (FEV1) significantly improved in all the three groups but it was better in (A) and (M + A) compared to (M) at 10 min and 20 min [10 min: 1.26 L ± 0.53 (A) vs. 1.10 L ± 0.27 (M), 1.35 L ± 0.59 (M + A) vs. 1.10 L ± 0.27 (M), p < 0.05; 20 min: 1.32 L ± 0.61 (A) vs. 1.17 L ± 0.30 (M), 1.42 L ± 0.59 (M + A) vs. 1.17 L ± 0.30 (M), p < 0.05]. Variation of FEV1, as absolute value at 10 min or 20 min over post-Ach FEV1 was significantly different in (A) or (M + A) compared to (M).

Conclusions

Nebulized albuterol and magnesium sulfate + albuterol can more effectively improve FEV1 in children with bronchial hyperresponsiveness than nebulized magnesium sulfate at 10 min and 20 min after inhalation. It is further suggested that addition of magnesium sulfate to albuterol does not result in additional benefit.
Literatur
1.
Zurück zum Zitat Nannini LJ Jr, Pendino JC, Corna RA, Mannarino S, Quispe R. Magnesium sulfate as a vehicle for nebulized salbutamol in acute asthma. Am J Med. 2000;108:193–7. Nannini LJ Jr, Pendino JC, Corna RA, Mannarino S, Quispe R. Magnesium sulfate as a vehicle for nebulized salbutamol in acute asthma. Am J Med. 2000;108:193–7.
2.
Zurück zum Zitat Hughes R, Goldkorn A, Masoli M, Weatherall M, Burgess C, Beasley R. Use of isotonic nebulized magnesium sulphate as an adjuvant to salbutamol in treatment of severe asthma in adults: randomized placebo-controlled trial. Lancet. 2003;361:2114–7.CrossRefPubMed Hughes R, Goldkorn A, Masoli M, Weatherall M, Burgess C, Beasley R. Use of isotonic nebulized magnesium sulphate as an adjuvant to salbutamol in treatment of severe asthma in adults: randomized placebo-controlled trial. Lancet. 2003;361:2114–7.CrossRefPubMed
3.
Zurück zum Zitat Devi PR, Kumar L, Singhi SC, Prasad R, Singh M. Intravenous magnesium sulfate in acute severe asthma not responding to conventional therapy. Indian Pediatr. 1997;34:389–97.PubMed Devi PR, Kumar L, Singhi SC, Prasad R, Singh M. Intravenous magnesium sulfate in acute severe asthma not responding to conventional therapy. Indian Pediatr. 1997;34:389–97.PubMed
4.
Zurück zum Zitat Singh AK, Gaur S, Kumar R. A randomized controlled trial of intravenous magnesium sulphate as an adjunct to standard therapy in acute severe asthma. Iran J Allergy Asthma Immunol. 2008;7:221–9.PubMed Singh AK, Gaur S, Kumar R. A randomized controlled trial of intravenous magnesium sulphate as an adjunct to standard therapy in acute severe asthma. Iran J Allergy Asthma Immunol. 2008;7:221–9.PubMed
5.
Zurück zum Zitat Meral A, Coker M, Tanac R. Inhalation therapy with magnesium sulfate and salbutamol sulfate in bronchial asthma. Turk J Pediatr. 1996;38:169–75.PubMed Meral A, Coker M, Tanac R. Inhalation therapy with magnesium sulfate and salbutamol sulfate in bronchial asthma. Turk J Pediatr. 1996;38:169–75.PubMed
6.
Zurück zum Zitat Mangat HS, D’Souza GA, Jacob MS. Nebulized magnesium sulphate versus nebulized salbutamol in acute bronchial asthma: a clinical trial. Eur Respir J. 1998;12:341–4.CrossRefPubMed Mangat HS, D’Souza GA, Jacob MS. Nebulized magnesium sulphate versus nebulized salbutamol in acute bronchial asthma: a clinical trial. Eur Respir J. 1998;12:341–4.CrossRefPubMed
7.
Zurück zum Zitat Rowe BH, Bretzlaff JA, Bourdon C, Bota GW, Camargo Jr CA. Magnesium sulfate for treating exacerbations of acute asthma in the emergency department. Cochrane Database Syst Rev. 2000;2: CD001490.PubMed Rowe BH, Bretzlaff JA, Bourdon C, Bota GW, Camargo Jr CA. Magnesium sulfate for treating exacerbations of acute asthma in the emergency department. Cochrane Database Syst Rev. 2000;2: CD001490.PubMed
8.
Zurück zum Zitat Rodrigo G, Rodrigo C, Burschtin O. Efficacy of magnesium sulfate in acute adult asthma: a meta-analysis of randomized trials. Am J Emerg Med. 2000;18:216–21.CrossRefPubMed Rodrigo G, Rodrigo C, Burschtin O. Efficacy of magnesium sulfate in acute adult asthma: a meta-analysis of randomized trials. Am J Emerg Med. 2000;18:216–21.CrossRefPubMed
9.
Zurück zum Zitat Kurtaran H, Karadag A, Catal F, Isik B, Uras N. Nebulized salbutamol and magnesium sulphate in acute asthma. Lancet. 2003;362:1079–80. Author reply 80.CrossRefPubMed Kurtaran H, Karadag A, Catal F, Isik B, Uras N. Nebulized salbutamol and magnesium sulphate in acute asthma. Lancet. 2003;362:1079–80. Author reply 80.CrossRefPubMed
10.
Zurück zum Zitat Schenk P, Vonbank K, Schnack B, Haber P, Lehr S, Smetana R. Intravenous magnesium sulfate for bronchial hyperreactivity: a randomized, controlled, double-blind study. Clin Pharmacol Ther. 2001;69:365–71.CrossRefPubMed Schenk P, Vonbank K, Schnack B, Haber P, Lehr S, Smetana R. Intravenous magnesium sulfate for bronchial hyperreactivity: a randomized, controlled, double-blind study. Clin Pharmacol Ther. 2001;69:365–71.CrossRefPubMed
11.
Zurück zum Zitat Hill JM, Britton J. Effect of intravenous magnesium sulphate on airway calibre and airway reactivity to histamine in asthmatic subjects. Br J Clin Pharmacol. 1996;42:629–31.CrossRefPubMed Hill JM, Britton J. Effect of intravenous magnesium sulphate on airway calibre and airway reactivity to histamine in asthmatic subjects. Br J Clin Pharmacol. 1996;42:629–31.CrossRefPubMed
12.
Zurück zum Zitat Hill J, Lewis S, Britton J. Studies of the effects of inhaled magnesium on airway reactivity to histamine and adenosine monophosphate in asthmatic subjects. Clin Exp Allergy. 1997;27:546–51.CrossRefPubMed Hill J, Lewis S, Britton J. Studies of the effects of inhaled magnesium on airway reactivity to histamine and adenosine monophosphate in asthmatic subjects. Clin Exp Allergy. 1997;27:546–51.CrossRefPubMed
13.
Zurück zum Zitat Amantea SL, Sanchez I, Piva JP, Garcia PC. Controversies in the pharmacological management of acute asthma in children. J Pediatr. 2002;78:S151–60. Amantea SL, Sanchez I, Piva JP, Garcia PC. Controversies in the pharmacological management of acute asthma in children. J Pediatr. 2002;78:S151–60.
14.
Zurück zum Zitat Powell C, Dwan K, Milan SJ, Beasley R, Hughes R, Knopp-Sihota JA, et al. Inhaled magnesium sulfate in the treatment of acute asthma. Cochrane Database Syst Rev. 2012;12: CD003898.PubMed Powell C, Dwan K, Milan SJ, Beasley R, Hughes R, Knopp-Sihota JA, et al. Inhaled magnesium sulfate in the treatment of acute asthma. Cochrane Database Syst Rev. 2012;12: CD003898.PubMed
15.
Zurück zum Zitat Altman DG, Bland JM. Treatment allocation by minimisation. BMJ. 2005;330:384. Altman DG, Bland JM. Treatment allocation by minimisation. BMJ. 2005;330:384.
16.
Zurück zum Zitat Zhang QL, Zheng JP, Yuan BT, He H, Wang J, An JY, et al. Feasibility and predicted equations of spirometry in Shenzhen preschool children. Zhonghua Er Ke Za Zhi. 2005;43:843–8.PubMed Zhang QL, Zheng JP, Yuan BT, He H, Wang J, An JY, et al. Feasibility and predicted equations of spirometry in Shenzhen preschool children. Zhonghua Er Ke Za Zhi. 2005;43:843–8.PubMed
17.
Zurück zum Zitat Mahajan P, Haritos D, Rosenberg N, Thomas R. Comparison of nebulized magnesium sulfate plus albuterol to nebulized albuterol plus saline in children with acute exacerbations of mild to moderate asthma. J Emerg Med. 2004;27:21–5.CrossRefPubMed Mahajan P, Haritos D, Rosenberg N, Thomas R. Comparison of nebulized magnesium sulfate plus albuterol to nebulized albuterol plus saline in children with acute exacerbations of mild to moderate asthma. J Emerg Med. 2004;27:21–5.CrossRefPubMed
18.
Zurück zum Zitat Agarwal R, Gupta D. No role for inhaled magnesium sulfate in the treatment of acute asthma? Pulm Pharmacol Ther. 2007;20:494.CrossRefPubMed Agarwal R, Gupta D. No role for inhaled magnesium sulfate in the treatment of acute asthma? Pulm Pharmacol Ther. 2007;20:494.CrossRefPubMed
19.
Zurück zum Zitat Kokturk N, Turktas H, Kara P, Mullaoglu S, Yilmaz F, Karamercan A. A randomized clinical trial of magnesium sulphate as a vehicle for nebulized salbutamol in the treatment of moderate to severe asthma attacks. Pulm Pharmacol Ther. 2005;18:416–21.CrossRefPubMed Kokturk N, Turktas H, Kara P, Mullaoglu S, Yilmaz F, Karamercan A. A randomized clinical trial of magnesium sulphate as a vehicle for nebulized salbutamol in the treatment of moderate to severe asthma attacks. Pulm Pharmacol Ther. 2005;18:416–21.CrossRefPubMed
20.
Zurück zum Zitat Nannini Jr LJ, Hofer D. Effect of inhaled magnesium sulfate on sodium metabisulfite-induced bronchoconstriction in asthma. Chest. 1997;111:858–61.CrossRefPubMed Nannini Jr LJ, Hofer D. Effect of inhaled magnesium sulfate on sodium metabisulfite-induced bronchoconstriction in asthma. Chest. 1997;111:858–61.CrossRefPubMed
21.
Zurück zum Zitat Gandia F, Guenard H, Sriha B, Tabka Z, Rouatbi S. Inhaled magnesium sulphate in the treatment of bronchial hyperresponsiveness. Magnes Res. 2012;25:168–76.PubMed Gandia F, Guenard H, Sriha B, Tabka Z, Rouatbi S. Inhaled magnesium sulphate in the treatment of bronchial hyperresponsiveness. Magnes Res. 2012;25:168–76.PubMed
22.
Zurück zum Zitat Alamoudi OS. Hypomagnesaemia in chronic, stable asthmatics: prevalence, correlation with severity and hospitalization. Eur Respir J. 2000;16:427–31.CrossRefPubMed Alamoudi OS. Hypomagnesaemia in chronic, stable asthmatics: prevalence, correlation with severity and hospitalization. Eur Respir J. 2000;16:427–31.CrossRefPubMed
23.
Zurück zum Zitat Zervas E, Loukides S, Papatheodorou G, Psathakis K, Tsindiris K, Panagou P, et al. Magnesium levels in plasma and erythrocytes before and after histamine challenge. Eur Respir J. 2000;16:621–5.CrossRefPubMed Zervas E, Loukides S, Papatheodorou G, Psathakis K, Tsindiris K, Panagou P, et al. Magnesium levels in plasma and erythrocytes before and after histamine challenge. Eur Respir J. 2000;16:621–5.CrossRefPubMed
24.
Zurück zum Zitat Rowe BH, Camargo Jr CA. The role of magnesium sulfate in the acute and chronic management of asthma. Curr Opin Pulm Med. 2008;14:70–6.CrossRefPubMed Rowe BH, Camargo Jr CA. The role of magnesium sulfate in the acute and chronic management of asthma. Curr Opin Pulm Med. 2008;14:70–6.CrossRefPubMed
Metadaten
Titel
Effect of Inhaled Magnesium Sulfate on Bronchial Hyperresponsiveness
verfasst von
Hui Wang
Yi Xiong
Caihui Gong
Lijuan Yin
Li Yan
Xiaoping Yuan
Sha Liu
Tiantian Shi
Jihong Dai
Publikationsdatum
01.04.2015
Verlag
Springer India
Erschienen in
Indian Journal of Pediatrics / Ausgabe 4/2015
Print ISSN: 0019-5456
Elektronische ISSN: 0973-7693
DOI
https://doi.org/10.1007/s12098-014-1476-6

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