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Clinical Oral Investigations

Erschienen in:

15.06.2018 | Original Article

Effect of intracanal medicaments on matrix metalloproteinase-9 and vasoactive intestinal peptide secretion in periapical lesions of re-treated canals: a randomized controlled clinical study

verfasst von: Mine Büker Özdemir, Ertuğrul Karataş, Mevlüt Albayrak, Yasin Bayır

Erschienen in: Clinical Oral Investigations | Ausgabe 2/2019

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Abstract

Objective

The aim of this study was to evaluate the effect of calcium hydroxide (Ca[OH]₂) and chlorhexidine (CHX) gel on matrix metalloproteinase-9 (MMP-9) and vasoactive intestinal peptide (VIP) secretion in periapical lesions.

Materials and methods

A total of 60 patients were randomly divided into two groups that were to receive different medications. Pre-and post-treatment samples were collected from the interstitial fluid of periapical lesions using sterile paper points. VIP and MMP-9 levels were measured by enzyme-linked immunosorbent assay kits, and the data were statistically analyzed.

Results

Gender and smoking habits had no effect on the pre- and post-treatment VIP and MMPs levels. Intragroup analyses revealed that in the Ca(OH)₂ group, the post-treatment VIP level was found to be significantly higher than the pre-treatment VIP level. In the CHX group, the post-treatment MMP-9 level was significantly higher than the pre-treatment MMP-9 level.

Conclusion

According to the results of the present study, the type of the medication affected the amount of periapical VIP and MMP-9 secretion.

Clinical relevance

VIP is a neuropeptide that promotes new bone formation. Thus, intracanal Ca(OH)₂ medication may accelerate the repair process of bone tissue.

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Titel: Effect of intracanal medicaments on matrix metalloproteinase-9 and vasoactive intestinal peptide secretion in periapical lesions of re-treated canals: a randomized controlled clinical study
verfasst von: Mine Büker Özdemir
Ertuğrul Karataş
Mevlüt Albayrak
Yasin Bayır
Publikationsdatum: 15.06.2018
Verlag: Springer Berlin Heidelberg
Erschienen in: Clinical Oral Investigations / Ausgabe 2/2019
Print ISSN: 1432-6981
Elektronische ISSN: 1436-3771
DOI: https://doi.org/10.1007/s00784-018-2517-8

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Effect of intracanal medicaments on matrix metalloproteinase-9 and vasoactive intestinal peptide secretion in periapical lesions of re-treated canals: a randomized controlled clinical study

Abstract

Objective

Materials and methods

Results

Conclusion

Clinical relevance

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Springer Medizin

Abstract

Objective

Materials and methods

Results

Conclusion

Clinical relevance

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