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01.11.2014 | Original Article

Effect of low-level laser therapy on repair of the bone compromised by radiotherapy

verfasst von: Jonas D. Batista, Darceny Zanetta-Barbosa, Sérgio V. Cardoso, Paula Dechichi, Flaviana S. Rocha, Rogério M. Pagnoncelli

Erschienen in: Lasers in Medical Science | Ausgabe 6/2014

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Abstract

Radiotherapy (RDT) is commonly used for cancer treatment, but high doses of ionizing radiation can directly affect healthy tissues. Positive biological effects of low-level laser therapy (LLLT) on bone repair have been demonstrated; however, this effect on surgical defects of bone previously compromised by radiotherapy has not been evaluated. The aim of this study was to investigate the influence of LLLT (λ = 830 nm) in femur repair after ionizing radiation. Twenty Wistar rats were divided into four groups: control group (GC, n = 5) creation of bone defects (BDs) only; laser group (GL), with BD and LLLT (n = 5); radiotherapy group (GR), submitted to RDT and BD (n = 5); and radiotherapy and laser group (GRL), submitted to RDT, BD, and LLLT (n = 5). GL and GRL received punctual laser application (DE = 210 J/cm², P = 50 mW, t = 120 s, and beam diameter of 0.04 cm²) immediately after surgery, with 48-h interval during 7 days. Animals were euthanized at 7 days after surgery, and bone sections were evaluated morphometrically with conventional microscopy. Bone repair was only observed in nonirradiated bone, with significant improvement in GL in comparison to GC. GR and GRL did not present any bone neoformation. The result demonstrated a positive local biostimulative effect of LLLT in normal bone. However, LLLT was not able to revert the bone metabolic damage due to ionizing radiation.

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Titel: Effect of low-level laser therapy on repair of the bone compromised by radiotherapy
verfasst von: Jonas D. Batista
Darceny Zanetta-Barbosa
Sérgio V. Cardoso
Paula Dechichi
Flaviana S. Rocha
Rogério M. Pagnoncelli
Publikationsdatum: 01.11.2014
Verlag: Springer London
Erschienen in: Lasers in Medical Science / Ausgabe 6/2014
Print ISSN: 0268-8921
Elektronische ISSN: 1435-604X
DOI: https://doi.org/10.1007/s10103-014-1602-8

Springer Medizin

Abstract

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