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Erschienen in: Der Anaesthesist 9/2017

27.06.2017 | Originalien

Effect of low tidal volume with PEEP on respiratory function in infants undergoing one-lung ventilation

verfasst von: Jing Liu, Xinfang Liao, Yongle Li, Hui Luo, Weijian Huang, Lingli Peng, Qin Fang, Zurong Hu

Erschienen in: Die Anaesthesiologie | Ausgabe 9/2017

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Abstract

Background

An increasing number of studies have shown that low tidal volume (TV) with positive end-expiratory pressure (PEEP) offers lung protection during one-lung ventilation (OLV). Considering the unique physiological characteristics of infants, we aimed to determine the feasibility and effect of low TV with PEEP in infants undergoing OLV during thoracoscopy.

Patients and methods

We randomized 60 infants to a conventional group (group I: TV, 8–10 ml/kg; RR, 23–45 bpm; PEEP, 0 cmH2O) or a low TV with PEEP group (group II: TV, 5–7 ml/kg; RR, 23–45 bpm; PEEP, 4–6 cmH2O). Arterial blood gas analyses were performed at four time points: 5 min of two-lung ventilation (TLV, T0), and 20 min, 40 min, and 60 min of OLV (T1, T2, T3); hemodynamic parameters (heart rate, mean blood pressure), temperature, as well as gas exchange (SpO2 and PETCO2) and ventilation parameters (FiO2, PEEP, Pmax) were recorded simultaneously. Lung compliance and shunt were also calculated.

Result

No significant difference was found between both groups at T0. Compared with T0, PETCO2, Pmax, PaCO2, lactic acid, and intrapulmonary shunt volume (Qs/Qt) were increased while PaO2 and respiratory system compliance (Cdyx) were decreased noticeably in both groups at T1, T2, and T3. At T1, T2, and T3, Pmax and Qs/Qt were much lower while PETCO2, PaCO2, and Cdyx were higher in group II than in group I. There was no significant difference in lactic acid and PaO2 measurements between the two groups at T1, T2, and T3.

Conclusion

Low TV with PEEP could be an effective intraoperative ventilation strategy for infants undergoing OLV during video-assisted thoracoscopic surgery and may reduce the risk of lung injury. However, this strategy, as well as the influence of intraoperative hypercapnia on infants, needs further investigation.
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Metadaten
Titel
Effect of low tidal volume with PEEP on respiratory function in infants undergoing one-lung ventilation
verfasst von
Jing Liu
Xinfang Liao
Yongle Li
Hui Luo
Weijian Huang
Lingli Peng
Qin Fang
Zurong Hu
Publikationsdatum
27.06.2017
Verlag
Springer Medizin
Erschienen in
Die Anaesthesiologie / Ausgabe 9/2017
Print ISSN: 2731-6858
Elektronische ISSN: 2731-6866
DOI
https://doi.org/10.1007/s00101-017-0330-4

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