Skip to main content
main-content

24.04.2019 | Original Article | Ausgabe 5/2019

The Journal of Obstetrics and Gynecology of India 5/2019

Effect of Melatonin on Blood Loss After Cesarean Section: A Prospective Randomized Double-Blind Trial

Zeitschrift:
The Journal of Obstetrics and Gynecology of India > Ausgabe 5/2019
Autoren:
MD Marzieh Beigom Khezri, MD Morteza Delkhosh Reihany, MD Talaat Dabbaghi Ghaleh, MD, MPH Navid Mohammadi
Wichtige Hinweise
Marzieh Beigom Khezri is working as associate professor of anesthesia in a tertiary teaching hospital, specialized for obstetrics and gynecology affiliated to Qazvin University of medical science. Her areas of interest in research are mostly in the fields of post-operative pain and obstetric hemorrhage management; Morteza Delkhosh Reihany has worked as an anesthesiologist since 2013. He completed his fellowship in palliative medicine last year. Furthermore, he works as an anesthesiologist and also in pain clinic for relieving chronic pains now. Dr. Delkhosh is interested in clinical research in the field of pain and advanced methods of anesthesia; Talaat Dabbaghi Ghaleh is an expert gynecologist with 24 years of educational and academic experience. She has also completed a fellowship in infertility and works in an infertility clinic too. Dr. Dabbaghi is a faculty in Qazvin University of Medical Sciences with the rank of the associate professor now; Navid Mohammadi is a practiced physician and associate professor in community and preventive medicine at Qazvin University of Medical Sciences, Iran. Dr. Mohammadi is also a director member of the preventive medicine and public health research center in Iran University of Medical Sciences, Tehran, Iran. He has completed fellowship in “simulation in medical education” from the University of Ottawa, Canada in 2015. Dr. Mohammadi is interested in clinical and epidemiological research to improve patient care as well as the level of knowledge about health problems in the community.

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Abstract

Background and Objectives

The similarities between the melatonin and oxytocin signaling could lead to increased contractility of myometrium. We designed this randomized double-blind, placebo-controlled trial to evaluate the efficacy of melatonin in reduction of blood loss during and after the lower segment cesarean section.

Methods

One hundred and twenty patients who had been scheduled for cesarean section under spinal anesthesia were enrolled in the study. We randomly allocated them to one of the three following groups to receive either melatonin 3 mg (M3), melatonin 6 mg (M6), or placebo (P) sublingually 20 min before the surgery. The hemoglobin levels before and 12 h after surgery, the mean weight of the materials used in the operation time, the need for additional oxytocic therapy, and the incidence of adverse effects were probed and recorded.

Results

There was a significant difference between the group M6 and both M3 and P in the mean weight of the materials (p = .024 and .041, respectively) and between M6 and P groups in terms of mean decrease in hemoglobin during 12 h after cesarean section (p = .029).

Conclusion

Using 6 mg melatonin, sublingually, as a premedication in patients undergoing cesarean section with spinal anesthesia could statistically reduce the amount of blood loss after the lower segment cesarean section, although it may not be clinically meaningful.
Registration number: ACTRN12612000117819 and ClinicalTrials.gov Identifier: NCT01572805

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

★ PREMIUM-INHALT
e.Med Interdisziplinär

Mit e.Med Interdisziplinär erhalten Sie Zugang zu allen CME-Fortbildungen und Fachzeitschriften auf SpringerMedizin.de. Zusätzlich können Sie eine Zeitschrift Ihrer Wahl in gedruckter Form beziehen – ohne Aufpreis.

Jetzt e.Med bestellen und 100 € sparen!

Weitere Produktempfehlungen anzeigen
Literatur
Über diesen Artikel

Weitere Artikel der Ausgabe 5/2019

The Journal of Obstetrics and Gynecology of India 5/2019 Zur Ausgabe
  1. Sie können e.Med Gynäkologie & Urologie 14 Tage kostenlos testen (keine Print-Zeitschrift enthalten). Der Test läuft automatisch und formlos aus. Es kann nur einmal getestet werden.

Neu im Fachgebiet Gynäkologie und Geburtshilfe

Meistgelesene Bücher aus dem Fachgebiet

2014 | Buch

Perikonzeptionelle Frauenheilkunde

Fertilitätserhalt, Prävention und Management von Schwangerschaftsrisiken

Ein Praxisbuch für alle, die in der Beratung und Betreuung von Schwangeren und Paaren mit Kinderwunsch tätig sind. Die Herausgeber und Autoren haben alle wichtigen Informationen zusammengetragen, um Frauen sicher zu beraten, zu betreuen und kompetent Verantwortung zu übernehmen.

Herausgeber:
Christian Gnoth, Peter Mallmann

2019 | Buch

Praxisbuch Gynäkologische Onkologie

Dieses kompakte und praxisrelevante Standardwerk richtet sich alle Ärzte in Klinik und Praxis, die Patientinnen mit bösartigen Tumoren des Genitales und der Mamma behandeln. Die 5. Auflage wurde komplett aktualisiert und auf der Basis …

Herausgeber:
Prof. Dr. Edgar Petru, Dr. Daniel Fink, Prof. Dr. Ossi R. Köchli, Prof. Dr. Sibylle Loibl

Mail Icon II Newsletter

Bestellen Sie unseren kostenlosen Newsletter Update Gynäkologie und bleiben Sie gut informiert – ganz bequem per eMail.

Bildnachweise