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01.12.2017 | Research article | Ausgabe 1/2017 Open Access

BMC Complementary and Alternative Medicine 1/2017

Effect of microbial siderophores on mammalian non-malignant and malignant cell lines

Zeitschrift:
BMC Complementary and Alternative Medicine > Ausgabe 1/2017
Autoren:
Karuna Gokarn, Vishwas Sarangdhar, Ramprasad B. Pal

Abstract

Background

Iron is a vital nutrient for all cells, and malignant cells have a higher requirement for the metal due to their rapid multiplication. Bacterial siderophores can be used to reduce free ferric ion concentration from the cellular environment.

Methods

In the present study, we have evaluated effect of three siderophores – exochelin-MS, mycobactin S and deferoxamine B on the proliferation of mammalian cell lines using MTT assay.

Results

These siderophores caused a significant decrease in the viability of malignant cells, without significantly affecting non-malignant cells.

Conclusions

Based on these results, we suggest that iron-chelation therapy could be explored as an adjunctive therapeutic option against cancer along with other therapies.
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