Background
Irradiation and vessels
Heat shock proteins (HSP)
Aim of the study
Methods
Patients
case No. | age | gender | pTNM | radiation dose (Gy) | time between radiation and surgery (months) | donor site | chemotherapy | neo adjuvant therapy | smoker |
---|---|---|---|---|---|---|---|---|---|
1 | 49 | m | pT2 pN1 | no radiation | ------ | radial forearm flap | ----- | yes | |
2 | 74 | m | pT4a pN2b | no radiation | ------ | radial forearm flap | ----- | no | |
3 | 51 | m | pT4a pN0 | no radiation | ------ | fibula flap | ----- | yes | |
4 | 84 | f | pT2 pN0 | no radiation | ------ | radial forearm flap | ----- | no | |
5 | 69 | f | pT4 pN2 | no radiation | ----- | radial forearm flap | ----- | no | |
6 | 46 | m | pT2 pN0 | no radiation | ------ | radial forearm flap | ----- | yes | |
7 | 65 | m | pT4 pN0 | no radiation | ----- | latissimus dorsi flap | ----- | yes | |
8 | 44 | m | pT1 pN0 | no radiation | ----- | radial forearm flap | ----- | yes | |
9 | 64 | m | pT1 pN0 | no radiation | ----- | radial forearm flap | ----- | yes | |
10 | 46 | m | pT2 pN1 | no radiation | ----- | lateral arm flap | ----- | no | |
11 | 55 | f | ypT1 pN0 | 40 | 1,5 | radial forearm flap | carboplatin + taxol | yes | yes |
12 | 48 | m | ypT1 pN0 | 40 | 1,5 | latissimus dorsi flap | carboplatin + taxol | yes | yes |
13 | 43 | m | ypT1 ypN1 | 40 | 1,5 | radial forearm flap | cisplatin/5-FU | yes | yes |
14 | 55 | m | ypT1 ypN0 | 40 | 1,5 | radial forearm flap | carboplatin + taxol | yes | yes |
15 | 57 | m | ypT1 ypN1 | 40 | 1,5 | latissimus dorsi flap | cisplatin/5-FU | yes | yes |
16 | 57 | m | pT4 pN3 | 60 | 108 | radial forearm flap | - | yes | |
17 | 64 | m | pT4 pN1 | 60 | 120 | latissimus dorsi flap | - | no | |
18 | 30 | m | pT2 pN2b | 59.4 | 22 | latissimus dorsi flap | - | no | |
19 | 51 | m | pT4 N2b | 61.2 | 20 | latissimus dorsi flap | - | yes | |
20 | 58 | m | pT4 N2a | 72 | 81 | radial forearm flap | - | no |
Immunhistochemistry
Quantitative evaluation
Evaluation of HSP 70 expression
Statistical analysis
Results
Clinical data
Vessel wall thickness
group 1 | group 2 | group 3 | ||||
---|---|---|---|---|---|---|
wall thickness [μm]
|
transplant
|
recipient
|
transplant
|
recipient
|
transplant
|
recipient
|
intima of veins | 18,6 ± 0,7 | 18,5 ± 0,6 | 21,0 ± 0,8 | 22,8 ± 4,8 | 45,6 ±4,0 | 43,1 ±6,1 |
media of veins | 184,7 ±6,3 | 212,1 ±10,6 | 121,8 ± 3,9 | 289,6 ± 10,5 | 190,9 ± 13,2 | 200,5 ±9,3 |
intima of arteries | 30,6 ± 2,0 | 32,8 ± 2,8 | 53,1 ± 2,8 | 72,5 ± 1,4 | 31,2 ± 3,2 | 77,1 ± 2,8 |
media of arteries | 439,8 ± 19,6 | 323,6 ± 11,6 | 423,9 ±3,0 | 262,0 ±13,2 | 283,8 ± 13,5 | 405,5 ± 7,14 |
HSP70 expression [%]
| ||||||
intima of veins | 2,04 ± 0,18 | 3,06 ± 0,14 | 4,22 ± 0,14 | 2,54 ± 0,44 | 2,27 ± 0,15 | 2,92 ± 0,54 |
media of veins | 2,42 ± 0,22 | 4,52 ± 0,21 | 2,46 ± 0,18 | 1,00 ± 0,05 | 4,55 ± 0,55 | 8,38 ± 0,94 |
intima of arteries | 0,19 ± 0,01 | 1,56 ± 0,24 | 0,75 ± 0,23 | 0,77 ± 0,09 | 0,60 ± 0,12 | 0,35 ± 0,23 |
media of arteries | 0,51 ± 0,07 | 2,41 ± 0,15 | 0,14 ± 0,01 | 0,32 ± 0,02 | 0,81 ± 0,19 | 4,41 ± 0,41 |