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20.01.2022 | Review

Effect of pathological complete response after neoadjuvant chemoradiotherapy on postoperative complications of rectal cancer: a systematic review and meta-analysis

verfasst von: J. Yang, W. Wang, Y. Luo, S. Huang, Z. Fu

Erschienen in: Techniques in Coloproctology | Ausgabe 3/2022

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Abstract

Background

Standard total mesorectal resection has become an important treatment option for locally advanced or high-risk rectal cancer after neoadjuvant chemo-radiotherapy. 15–27% of patients can achieve pathological complete response (PCR) after neoadjuvant chemo-radiotherapy (nCRT). However, the relationship between PCR and postoperative complications remains an important unsolved problem. The objective of this study was to determine whether PCR was associated with the rate of postoperative complications.

Methods

This meta-analysis was implemented following the recommendations from Preferred Reporting Items for Systematic Reviews and Meta-Analyses. We searched electronic literature by PubMed, EMBASE, and Google Scholar. Major outcomes of interest included anastomotic leakage, surgical-site infection, reoperation, and any postoperative complications. Other outcomes comprised postoperative hemorrhage, ileus, and mortality.

Results

Eleven thousand two hundred ninety patients in 9 studies were included in the meta-analysis. The pooled analysis revealed that patients with PCR did not have a higher risk of anastomotic leakage (OR = 1.22, 95% CI 0.92–1.62, p = 0.17), reoperation (OR = 1.13, 95% CI 0.93–1.37, p = 0.22), and any postoperative complications (OR = 1.02, 95% CI 0.91–1.15, p = 0.72) than patients with non-PCR. However, the meta-analysis showed that the PCR group was superior to the non-PCR group in terms of surgical-site infection (9.38% vs. 12.44%OR = 0.68, 95% CI 0.47–0.98; p = 0.04).

Conclusion

PCR might not be related to the occurrence of postoperative complications in rectal cancer patients following nCRT. In addition, PCR might be associated with a lower risk of surgical-site infection.
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Metadaten
Titel
Effect of pathological complete response after neoadjuvant chemoradiotherapy on postoperative complications of rectal cancer: a systematic review and meta-analysis
verfasst von
J. Yang
W. Wang
Y. Luo
S. Huang
Z. Fu
Publikationsdatum
20.01.2022
Verlag
Springer International Publishing
Erschienen in
Techniques in Coloproctology / Ausgabe 3/2022
Print ISSN: 1123-6337
Elektronische ISSN: 1128-045X
DOI
https://doi.org/10.1007/s10151-021-02564-y

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