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11.10.2019 | Clinical trial

Effect of progressive resistance training on persistent pain after axillary dissection in breast cancer: a randomized controlled trial

Breast Cancer Research and Treatment
Gunn Ammitzbøll, Kenneth Geving Andersen, Pernille Envold Bidstrup, Christoffer Johansen, Charlotte Lanng, Niels Kroman, Bo Zerahn, Ole Hyldegaard, Elisabeth Wreford Andersen, Susanne Oksbjerg Dalton
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The online version of this article (https://​doi.​org/​10.​1007/​s10549-019-05461-z) contains supplementary material, which is available to authorised users.

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Persistent pain is a known challenge among breast cancer survivors. In secondary analyses of a randomized controlled trial, we examined the effect of progressive resistance training on persistent pain in the post-operative year in women treated for breast cancer with axillary lymph node dissection.


We randomized 158 women after BC surgery with Axillary Lymph Node Dissection (ALND) (1:1) to usual care or a 1-year, supervised and self-administered, progressive resistance training intervention initiated 3 weeks after surgery. A questionnaire at baseline, 20 weeks and 12 months assessed the intensity and frequency of pain, neuropathic pain and influence of pain on aspects of daily life. We analysed the effect using linear mixed models and multinomial logistic regression models for repeated measures.


A high percentage of participants experienced baseline pain (85% and 83% in the control and intervention groups respectively) and by the 12 month assessment these numbers were more than halved. A high proportion of participants also experienced neuropathic pain (88% and 89% in control and intervention group respectively), a finding that was stable throughout the study period. The effect on intensity of pain indicators favoured the exercise group, although most estimates did not reach statistical significance, with differences being small.


For women who had BC surgery with ALND, our progressive resistance training intervention conferred no benefit over usual care in reducing pain. Importantly, it did not increase the risk of pain both in the short and long term rehabilitative phase.

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