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26.05.2020 | Original Article

Effect of small vessel disease burden and lacunes on gait/posture impairment in Parkinson’s disease

verfasst von: Huimin Chen, Meimei Zhang, Gengliang Liu, Xuemei Wang, Zhan Wang, Huizi Ma, Yuesong Pan, David Wang, Yilong Wang, Tao Feng

Erschienen in: Neurological Sciences | Ausgabe 12/2020

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Abstract

Introduction

The comorbidity of cerebral small vessel disease (CSVD) may worsen gait impairment of Parkinson’s disease (PD). However, the evidence remains scarce and controversial, and the mechanism of their potential interaction remains largely unknown. The present study aimed to investigate the overall impact of quantity and location of CSVD on gait/posture function in PD.

Methods

This cross-sectional study included 315 consecutive eligible patients with PD from Beijing Tiantan Hospital from May 2016 to August 2018. Associations of gait/posture subscores with the burden score of CSVD and four CSVD imaging markers were assessed using multivariate linear regression models.

Results

Burden of CSVD was significantly associated with more severe gait/posture impairment in PD in the unadjusted model (β = 0.521, P = 0.011, 95% CI 0.118–0.923) and in the model adjusted for age, hypertension, ischemic stroke, low-density lipoprotein level, cholesterol level, and cognitive statues (β = 0.448, P = 0.047, 95% CI 0.006–0.891). The presence of lacunes, but not other CSVD markers, was significantly associated with higher gait/posture subscores after the adjustment (β = 0.492, P = 0.041, 95% CI 0.021–0.964), and the number of lacunes in the basal ganglia significantly correlated with the gait/posture subscores in patients with PD (P = 0.012, Spearman r = 0.161).

Conclusions

CSVD and lacunes in the basal ganglia may independently contribute to gait/posture dysfunction in PD. Promoting neurovascular health may preserve some gait/posture function of PD.

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Wardlaw JM, Smith EE, Biessels GJ, Cordonnier C, Fazekas F, Frayne R, Lindley RI, O’Brien JT, Barkhof F, Benavente OR, Black SE, Brayne C, Breteler M, Chabriat H, Decarli C, de Leeuw FE, Doubal F, Duering M, Fox NC, Greenberg S, Hachinski V, Kilimann I, Mok V, Oostenbrugge R, Pantoni L, Speck O, Stephan BC, Teipel S, Viswanathan A, Werring D, Chen C, Smith C, van Buchem M, Norrving B, Gorelick PB, Dichgans M, nEuroimaging STfRVco (2013) Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration. Lancet Neurol 12(8):822–838. https://doi.org/10.1016/S1474-4422(13)70124-8CrossRefPubMedPubMedCentral

van der Holst HM, van Uden IW, Tuladhar AM, de Laat KF, van Norden AG, Norris DG, van Dijk EJ, Esselink RA, Platel B, de Leeuw FE (2015) Cerebral small vessel disease and incident parkinsonism: the RUN DMC study. Neurology 85(18):1569–1577. https://doi.org/10.1212/WNL.0000000000002082CrossRefPubMedPubMedCentral

Thompson PD, Marsden CD (1987) Gait disorder of subcortical arteriosclerotic encephalopathy: Binswanger’s disease. Mov Disord 2(1):1–8. https://doi.org/10.1002/mds.870020101CrossRefPubMed

Schwartz RS, Halliday GM, Cordato DJ, Kril JJ (2012) Small-vessel disease in patients with Parkinson’s disease: a clinicopathological study. Mov Disord 27(12):1506–1512. https://doi.org/10.1002/mds.25112CrossRefPubMed

Marras C, Canning CG, Goldman SM (2019) Environment, lifestyle, and Parkinson’s disease: implications for prevention in the next decade. Mov Disord 34(6):801–811. https://doi.org/10.1002/mds.27720CrossRefPubMed

Vesely B, Antonini A, Rektor I (2016) The contribution of white matter lesions to Parkinson’s disease motor and gait symptoms: a critical review of the literature. J Neural Transm (Vienna) 123(3):241–250. https://doi.org/10.1007/s00702-015-1470-9CrossRef

Vesely B, Rektor I (2016) The contribution of white matter lesions (WML) to Parkinson’s disease cognitive impairment symptoms: a critical review of the literature. Parkinsonism Relat Disord 22(Suppl 1):S166–S170. https://doi.org/10.1016/j.parkreldis.2015.09.019CrossRefPubMed

Staals J, Booth T, Morris Z, Bastin ME, Gow AJ, Corley J, Redmond P, Starr JM, Deary IJ, Wardlaw JM (2015) Total MRI load of cerebral small vessel disease and cognitive ability in older people. Neurobiol Aging 36(10):2806–2811. https://doi.org/10.1016/j.neurobiolaging.2015.06.024CrossRefPubMedPubMedCentral

Hatate J, Miwa K, Matsumoto M, Sasaki T, Yagita Y, Sakaguchi M, Kitagawa K, Mochizuki H (2016) Association between cerebral small vessel diseases and mild parkinsonian signs in the elderly with vascular risk factors. Parkinsonism Relat Disord 26:29–34. https://doi.org/10.1016/j.parkreldis.2016.02.011CrossRefPubMed

10.

Sweeney MD, Kisler K, Montagne A, Toga AW, Zlokovic BV (2018) The role of brain vasculature in neurodegenerative disorders. Nat Neurosci 21(10):1318–1331. https://doi.org/10.1038/s41593-018-0234-xCrossRefPubMedPubMedCentral

11.

Sweeney MD, Zhao Z, Montagne A, Nelson AR, Zlokovic BV (2019) Blood-brain barrier: from physiology to disease and back. Physiol Rev 99(1):21–78. https://doi.org/10.1152/physrev.00050.2017CrossRefPubMed

12.

Wardlaw JM, Smith C, Dichgans M (2019) Small vessel disease: mechanisms and clinical implications. Lancet Neurol 18(7):684–696. https://doi.org/10.1016/S1474-4422(19)30079-1CrossRefPubMed

13.

Ter Telgte A, van Leijsen EMC, Wiegertjes K, Klijn CJM, Tuladhar AM, de Leeuw FE (2018) Cerebral small vessel disease: from a focal to a global perspective. Nat Rev Neurol 14(7):387–398. https://doi.org/10.1038/s41582-018-0014-yCrossRefPubMed

14.

Postuma RB, Berg D, Stern M, Poewe W, Olanow CW, Oertel W, Obeso J, Marek K, Litvan I, Lang AE, Halliday G, Goetz CG, Gasser T, Dubois B, Chan P, Bloem BR, Adler CH, Deuschl G (2015) MDS clinical diagnostic criteria for Parkinson’s disease. Mov Disord 30(12):1591–1601. https://doi.org/10.1002/mds.26424CrossRefPubMed

15.

Tomlinson CL, Stowe R, Patel S, Rick C, Gray R, Clarke CE (2010) Systematic review of levodopa dose equivalency reporting in Parkinson’s disease. Mov Disord 25(15):2649–2653. https://doi.org/10.1002/mds.23429CrossRefPubMed

16.

Feng T, Li W, Lu L, Wang Y, Shi W, Zhang J, Wang Y, Chan P (2009) Acute stepwise challenge test with levodopa in treated patients with parkinsonism. Parkinsonism Relat Disord 15(5):354–358. https://doi.org/10.1016/j.parkreldis.2008.08.010CrossRefPubMed

17.

Fazekas F, Kleinert R, Offenbacher H, Schmidt R, Kleinert G, Payer F, Radner H, Lechner H (1993) Pathologic correlates of incidental MRI white matter signal hyperintensities. Neurology 43(9):1683–1689. https://doi.org/10.1212/wnl.43.9.1683CrossRefPubMed

18.

Doubal FN, MacLullich AM, Ferguson KJ, Dennis MS, Wardlaw JM (2010) Enlarged perivascular spaces on MRI are a feature of cerebral small vessel disease. Stroke 41(3):450–454. https://doi.org/10.1161/STROKEAHA.109.564914CrossRefPubMed

19.

Lau KK, Li L, Schulz U, Simoni M, Chan KH, Ho SL, Cheung RTF, Kuker W, Mak HKF, Rothwell PM (2017) Total small vessel disease score and risk of recurrent stroke: validation in 2 large cohorts. Neurology 88(24):2260–2267. https://doi.org/10.1212/WNL.0000000000004042CrossRefPubMedPubMedCentral

20.

Bohnen NI, Muller ML, Zarzhevsky N, Koeppe RA, Bogan CW, Kilbourn MR, Frey KA, Albin RL (2011) Leucoaraiosis, nigrostriatal denervation and motor symptoms in Parkinson’s disease. Brain 134(Pt 8):2358–2365. https://doi.org/10.1093/brain/awr139CrossRefPubMedPubMedCentral

21.

Kotagal V, Albin RL, Muller ML, Koeppe RA, Frey KA, Bohnen NI (2014) Modifiable cardiovascular risk factors and axial motor impairments in Parkinson disease. Neurology 82(17):1514–1520. https://doi.org/10.1212/WNL.0000000000000356CrossRefPubMedPubMedCentral

22.

Malek N, Lawton MA, Swallow DM, Grosset KA, Marrinan SL, Bajaj N, Barker RA, Burn DJ, Hardy J, Morris HR, Williams NM, Wood N, Ben-Shlomo Y, Grosset DG, Consortium PRC (2016) Vascular disease and vascular risk factors in relation to motor features and cognition in early Parkinson’s disease. Mov Disord 31(10):1518–1526. https://doi.org/10.1002/mds.26698CrossRefPubMedPubMedCentral

23.

Song IU, Kim YD, Cho HJ, Chung SW (2013) The effects of silent cerebral ischemic lesions on the prognosis of idiopathic Parkinson’s disease. Parkinsonism Relat Disord 19(8):761–763. https://doi.org/10.1016/j.parkreldis.2013.04.006CrossRefPubMed

24.

Chung SJ, Lee YH, Yoo HS, Oh JS, Kim JS, Ye BS, Sohn YH, Lee PH (2019) White matter hyperintensities as a predictor of freezing of gait in Parkinson’s disease. Parkinsonism Relat Disord 66:105–109. https://doi.org/10.1016/j.parkreldis.2019.07.019CrossRefPubMed

25.

Chen HM, Sha ZQ, Ma HZ, He Y, Feng T (2018) Effective network of deep brain stimulation of subthalamic nucleus with bimodal positron emission tomography/functional magnetic resonance imaging in Parkinson’s disease. CNS Neurosci Ther 24(2):135–143. https://doi.org/10.1111/cns.12783CrossRefPubMed

26.

Albin RL, Young AB, Penney JB (1995) The functional anatomy of disorders of the basal ganglia. Trends Neurosci 18(2):63–64CrossRefPubMed

27.

Albin RL, Young AB, Penney JB (1989) The functional anatomy of basal ganglia disorders. Trends Neurosci 12(10):366–375CrossRefPubMed

28.

Joutsa J, Horn A, Hsu J, Fox MD (2018) Localizing parkinsonism based on focal brain lesions. Brain 141(8):2445–2456. https://doi.org/10.1093/brain/awy161CrossRefPubMedPubMedCentral

29.

Antonini A, Vitale C, Barone P, Cilia R, Righini A, Bonuccelli U, Abbruzzese G, Ramat S, Petrone A, Quatrale R, Marconi R, Ceravolo R, Stefani A, Lopiano L, Zappia M, Capus L, Morgante L, Tamma F, Tinazzi M, Colosimo C, Guerra UP (2012) The relationship between cerebral vascular disease and parkinsonism: the VADO study. Parkinsonism Relat Disord 18(6):775–780. https://doi.org/10.1016/j.parkreldis.2012.03.017CrossRefPubMed

Titel: Effect of small vessel disease burden and lacunes on gait/posture impairment in Parkinson’s disease
verfasst von: Huimin Chen
Meimei Zhang
Gengliang Liu
Xuemei Wang
Zhan Wang
Huizi Ma
Yuesong Pan
David Wang
Yilong Wang
Tao Feng
Publikationsdatum: 26.05.2020
Verlag: Springer International Publishing
Erschienen in: Neurological Sciences / Ausgabe 12/2020
Print ISSN: 1590-1874
Elektronische ISSN: 1590-3478
DOI: https://doi.org/10.1007/s10072-020-04452-z

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Effect of small vessel disease burden and lacunes on gait/posture impairment in Parkinson’s disease

Abstract

Introduction

Methods

Results

Conclusions

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Parkinson-Therapie im Wandel – aktuelle Leitlinie im Fokus

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Hustenstiller lindert Agitation bei Alzheimer

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Abstract

Introduction

Methods

Results

Conclusions

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