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01.12.2014 | Research article | Ausgabe 1/2014 Open Access

BMC Gastroenterology 1/2014

Effect of statin use on outcome of symptomatic cholelithiasis: a case-control study

Zeitschrift:
BMC Gastroenterology > Ausgabe 1/2014
Autoren:
Jukka Pulkkinen, Matti Eskelinen, Vesa Kiviniemi, Tuukka Kotilainen, Markus Pöyhönen, Lasse Kilpeläinen, Pirjo Käkelä, Helena Kastarinen, Hannu Paajanen
Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1186/​1471-230X-14-119) contains supplementary material, which is available to authorized users.

Competing interests

The authors declare that they have no competing interests.

Authors’ contributions

JP revised the data, performed the statistical analysis and drafted the tables and the manuscript. He made substantial contributions to conception and design of study. HK revised manuscript and helped greatly to draft the manuscript. ME, PK revised manuscript. VK revised tables, advised the use of statistics and interpretation of data. TK, MP, LK collected data and drew up a part of the preliminary results. HP conceived of the study and participated in its design and coordination and helped to draft the manuscript and gave final approval of the version to be published. All authors read and approved the final manuscript.

Abstract

Background

Statins can modify bile cholesterol and, thus, the formation of gallstones. We examined whether statin use also modifies the severity of symptomatic gallstone disease and its treatment.

Methods

A total of 1,140 consecutive patients with symptomatic gallstone disease were recruited during 2008-2010 at Kuopio university hospital, Finland. Case-control analysis matched the patients using (n = 272) or not using (n = 272) statins by age and sex. The baseline characteristics of the patients, need and type of surgical treatment, duration of operation, perioperative bleeding, postoperative complications and overall mortality rate were compared statistically between the study groups.

Results

Morbidity and subsequent polypharmacy occurred more frequently among the patients with statins compared to the patients without statins. There were no significant differences between the statin users and non-users regarding surgical treatment (open vs. laparoscopic cholecystectomy). The mean operation time for laparoscopic cholecystectomy was 10% shorter for the patients with statin use than for the patients without. In addition, there was a non-significant tendency for statin users to bleed less during laparoscopic operations than the non-users. There were no differences in other procedure-related parameters (e.g., operation urgency, conversions, choledochotomies, complications and mortality) in patients with or without statins.

Conclusions

Compared to no treatment, statin treatment was associated with a shorter operation time for laparoscopy cholecystectomy. Other surgical outcome parameters were similar in patients with or without statins, although statin users had more polypharmacy and circulatory illnesses than non-users.
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