Erschienen in:
01.04.2010 | Short Communication
Effective adoptive therapy of tap-deficient lymphoma using diverse high avidity alloreactive T cells
verfasst von:
Zoran Popmihajlov, Fabio R. Santori, Daniel Gebreselassie, Anthony D. Sandler, Stanislav Vukmanovic
Erschienen in:
Cancer Immunology, Immunotherapy
|
Ausgabe 4/2010
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Abstract
High avidity for antigen and diversity of T cell receptor (TCR) repertoire are essential for effective immunity against cancer. We have previously created a transgenic mouse strain with increased TCR avidity in a diverse T cell population. In this report, we show that strong alloreactive responses of transgenic T cells against targets with low MHC class I expression can be used for effective adoptive transfer of tumor immunity in vivo. Alloreactive transgenic T cells could be an effective therapeutic approach counteracting tumor evasion of the immune system.