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Erschienen in: Breast Cancer Research and Treatment 2/2015

01.01.2015 | Clinical trial

Effectiveness of an additional individualized multi-component complementary medicine treatment on health-related quality of life in breast cancer patients: a pragmatic randomized trial

verfasst von: Claudia M. Witt, Oskar Außerer, Susanne Baier, Herbert Heidegger, Katja Icke, Oswald Mayr, Manfred Mitterer, Stephanie Roll, Gilbert Spizzo, Arthur Scherer, Christian Thuile, Anton Wieser, Lena Schützler

Erschienen in: Breast Cancer Research and Treatment | Ausgabe 2/2015

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Abstract

The aim of this study was to evaluate the effectiveness of an additional, individualized, multi-component complementary medicine treatment offered to breast cancer patients at the Merano Hospital (South Tyrol) on health-related quality of life compared to patients receiving usual care only. A randomized pragmatic trial with two parallel arms was performed. Women with confirmed diagnoses of breast cancer were randomized (stratified by usual care treatment) to receive individualized complementary medicine (CM group) or usual care alone (usual care group). Both groups were allowed to use conventional treatment for breast cancer. Primary endpoint was the breast cancer-related quality of life FACT-B score at 6 months. For statistical analysis, we used analysis of covariance (with factors treatment, stratum, and baseline FACT-B score) and imputed missing FACT-B scores at 6 months with regression-based multiple imputation. A total of 275 patients were randomized between April 2011 and March 2012 to the CM group (n = 136, 56.3 ± 10.9 years of age) or the usual care group (n = 139, 56.0 ± 11.0). After 6 months from randomization, adjusted means for health-related quality of life were higher in the CM group (FACT-B score 107.9; 95 % CI 104.1–111.7) compared to the usual care group (102.2; 98.5–105.9) with an adjusted FACT-B score difference between groups of 5.7 (2.6–8.7, p < 0.001). Thus, an additional individualized and complex complementary medicine intervention improved quality of life of breast cancer patients compared to usual care alone. Further studies evaluating specific effects of treatment components should follow to optimize the treatment of breast cancer patients.
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Metadaten
Titel
Effectiveness of an additional individualized multi-component complementary medicine treatment on health-related quality of life in breast cancer patients: a pragmatic randomized trial
verfasst von
Claudia M. Witt
Oskar Außerer
Susanne Baier
Herbert Heidegger
Katja Icke
Oswald Mayr
Manfred Mitterer
Stephanie Roll
Gilbert Spizzo
Arthur Scherer
Christian Thuile
Anton Wieser
Lena Schützler
Publikationsdatum
01.01.2015
Verlag
Springer US
Erschienen in
Breast Cancer Research and Treatment / Ausgabe 2/2015
Print ISSN: 0167-6806
Elektronische ISSN: 1573-7217
DOI
https://doi.org/10.1007/s10549-014-3249-3

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