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Erschienen in: Pediatric Surgery International 7/2018

04.05.2018 | Original Article

Effectiveness of gabapentin as a postoperative analgesic in children undergoing appendectomy

verfasst von: Katherine J. Baxter, Jennifer Hafling, Jennifer Sterner, Adarsh U. Patel, Helen Giannopoulos, Kurt F. Heiss, Mehul V. Raval

Erschienen in: Pediatric Surgery International | Ausgabe 7/2018

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Abstract

Purpose

Though gabapentin is increasingly used as a perioperative analgesic, data regarding effectiveness in children are limited. The purpose of this study was to evaluate gabapentin as a postoperative analgesic in children undergoing appendectomy.

Methods

A 12-month retrospective review of children undergoing appendectomy was performed at a two-hospital children’s institution. Patients receiving gabapentin (GP) were matched (1:2) with patients who did not receive gabapentin (NG) based on age, sex and appendicitis severity. Outcome measures included postoperative opioid use, pain scores, and revisits/readmissions.

Results

We matched 29 (33.3%) GP patients with 58 (66.6%) NG patients (n = 87). The GP group required significantly less postoperative opioids than the NG group (0.034 mg morphine equivalents/kg (ME/kg) vs. 0.106 ME/kg, p < 0.01). Groups had similar lengths of time from operation to pain scores ≤ 3 (GP 12.21 vs. NG 17.01 h, p = 0.23). GP and NG had similar rates of revisit to the emergency department (13.8 vs. 10.3%, p = 0.73), readmission (6.9 vs. 1.7%, p = 0.26), and revisits secondary to surgical pain (3.4 vs. 3.4%, p = 1.00).

Conclusion

In this single-center, retrospective cohort study, gabapentin is associated with a reduction in total postoperative opioid use in children with appendicitis. While promising, further prospective validation of clinical effectiveness is needed.
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Metadaten
Titel
Effectiveness of gabapentin as a postoperative analgesic in children undergoing appendectomy
verfasst von
Katherine J. Baxter
Jennifer Hafling
Jennifer Sterner
Adarsh U. Patel
Helen Giannopoulos
Kurt F. Heiss
Mehul V. Raval
Publikationsdatum
04.05.2018
Verlag
Springer Berlin Heidelberg
Erschienen in
Pediatric Surgery International / Ausgabe 7/2018
Print ISSN: 0179-0358
Elektronische ISSN: 1437-9813
DOI
https://doi.org/10.1007/s00383-018-4274-9

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