Background
Methods
Trial design
Participants and setting
Intervention
Parameter measurement
Sample size calculation
Statistical analysis
Results
Patients
Test Group | Control Group | t/χ2 Value | P Value | |
---|---|---|---|---|
Age (years) | 70.3 ± 5.9 | 70.4 ± 5.2 | −0.155 | 0.877 |
Sex (male n (%)) | 76 (53.9) | 65 (46.1) | 2.163 | 0.141 |
ASA I (%) | 44 (51.8) | 41 (48.2) | 0.752 | 0.687 |
ASA II(%) | 38 (52.1) | 35 (47.9) | ||
ASA III(%) | 43 (46.2) | 50 (53.8) | ||
Operation time (hours) | 1.6 ± 0.6 | 1.6 ± 0.6 | t = −0.693 | 0.489 |
Depth of anaesthesia | 48.3 ± 4.4 | 47.6 ± 4.5 | t = 1.279 | 0.202 |
Primary outcomes
Group | Before induction | Before intubation | Instant intubation | 1 min after intubation | Instant extubation | 1 min after extubation | 3 min after extubation | F Value | P Value | |
---|---|---|---|---|---|---|---|---|---|---|
SBP (mm Hg) | Test group | 141.8 ± 5.9 | 131.8 ± 5.3 | 128.8 ± 4.8 | 126.8 ± 4.6 | 123.8 ± 3.9 | 120.8 ± 3.7 | 119.9 ± 3.4 | 62.271 | < 0.0001 |
Control group | 139.7 ± 5.4 | 133.8 ± 4.9 | 131.8 ± 4.6 | 130.8 ± 4.2 | 131.9 ± 3.7 | 129.8 ± 3.5 | 127.9 ± 3.3 | |||
DBP (mm Hg) | Test group | 81.8 ± 5.9 | 74.8 ± 5.3 | 73.8 ± 4.8 | 74.8 ± 4.6 | 69.8 ± 3.9 | 71.8 ± 3.7 | 69.9 ± 3.4 | 150.875 | < 0.0001 |
Control group | 82.7 ± 5.4 | 75.8 ± 4.9 | 81.8 ± 4.6 | 80.8 ± 4.2 | 82.9 ± 3.7 | 80.8 ± 3.5 | 79.9 ± 3.3 | |||
HR (beat/min) | Test group | 85.8 ± 5.9 | 77.8 ± 5.3 | 82.8 ± 4.8 | 80.8 ± 4.6 | 82.8 ± 3.9 | 80.8 ± 3.7 | 82.9 ± 3.4 | 75.627 | < 0.0001 |
Control group | 85.7 ± 5.4 | 77.8 ± 4.9 | 89.8 ± 4.6 | 88.8 ± 4.2 | 89.9 ± 3.7 | 88.8 ± 3.5 | 86.9 ± 3.3 |
Treatment Group | Control Group | χ2 Value | P Value | |
---|---|---|---|---|
Spontaneous cough [case (%)] | 4 (3.1) | 13 (10.7) | 10.591 | 0.001 |
Induces cough [case (%)] | 8 (6.4) | 27 (21.4) | 10.806 | 0.001 |