Background
Methods
Search strategy
Selection criteria and exclusion criteria
Selection criteria
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Research Type
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Research Subjects
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Interventions
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Outcomes (Clinical effectiveness rate, Symptom score, Visual analogue score, Peripheral blood PGF2α, Side effects)
Research type
Research subjects
Interventions
Outcomes
Exclusion criteria
Data extraction and quality assessment
Statistical analyses
Results
Study selection
Characteristics of the included studies
Studies | Randomization Method | Sample Size Intervention/Control | Age(I/C) | Intervention | Outcomes | Time of initiation of acupoint-stimulation and Course of Treatment | Follow-up Visit | ||
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Intervention group | Control group | Primary | Secondary | ||||||
Zhang LM et al. (2012) [22] | Random number table | 45/45 | 13–27/11–25 | Acupuncture at SP 10 SP 6 CV 6 LI 4 | Indometacin | Clinical efficacy | N/A | The treatment started 3 days before menstrual onset, once every day and was given for 3 days for 3 menstrual cycles | 3 months |
Lin Q et al. (2012) [23] | Random number table | 80/60 | 15–30/15–30 | Eye acupuncture at the lower-jiao area; liver area; kidney area; the liver area; the heart area; the spleen area | Ibuprofen | Clinical efficacy | Uterine artery blood flow signals | The treatment started 5 days before menstrual onset, once every day and was given for 4–5 days for 3 menstrual cycles | 3 months |
Hu YL et al. (2012) [18] | Random number table | 60/50 | 15–30/15–29 | Eye acupuncture at the lower-jiao area; liver area; kidney area; the liver area; the heart area; the spleen area | Ibuprofen | Clinical efficacy | PGF2α+ recurrence rate | The treatment started 2 days before menstrual onset, once every day and was given for 4–5 days for 3 menstrual cycles | 6 months |
Cao Y et al. (2011) [24] | Random number table | 29/30 | 15–29/20–28 | Acupuncture at EX-B8 SP 8 BL 32 | Ibuprofen | Clinical efficacy | symptom score+ VAS + side effects | The treatment started during the menstrual period, once every day and was given for 3 menstrual cycles | 3 months |
Zhi LX et al. (2007) [25] | SPSS Random number | 60/60 | 19.60 ± 3.20/18.93 ± 2.60 | Superficial needling at SP 6 | Indometacin | Clinical efficacy | symptom score+ analgesic time | The treatment started 3 days before menstrual onset, once every day and was given for 5 days for 3 menstrual cycles | 3 months |
Bo LN et al. (2013) [26] | Random number table | 69/64 | 13–35 | Moxibustion at CV 4 CV 8 SP 6 | Fenbid | N/A | VAS + COX + PGF2α + OT + side effects | The treatment started 7 days before menstrual onset, once every day and was given for 7 days for 3 menstrual cycles | 3 months |
Ren XL et al. (2013) [27] | Registration order | 40/40 | 16–28/18–27 | Moxibustion at CV 4 SP 6 | Ibuprofen | Clinical efficacy | PGF2α
| The treatment started 3 days before menstrual onset, once every day and was given for 6 days for 3 menstrual cycles | 3 months |
Zhu Y et al. (2010) [28] | Random number table | 51/51 | 18–26/19–25 | Sandwiched moxibustion at CV 8 | Indometacin | Clinical efficacy | symptom score +side effects | The treatment started 3 days before menstrual onset, once every day and was given for 5 days for 3 menstrual cycles | 3 months |
Li JM et al. (2012) [29] | Random number table | 30/30 | 19–30 | Electroacupuncture at BL 32 | Fenbid | Clinical efficacy | symptom score | The treatment started during the menstrual period, once every day and was given for 3 menstrual cycles | 3 months |
Wang K et al. (2005) [30] | Random number table | 30/28 | 16–28/15–24 | Ear acupoint at TF 2 CO 18 CO 10 CO 12 | Indometacin | Clinical efficacy | N/A | The treatment started 3 days before menstrual onset, once every day and was given for 6 days for 3 menstrual cycles | 3 months |
Yang M et al. (2009) [31] | Random number table | 36/36 | 14–28/13–27 | Acupoint application at CV 4 | Indometacin | Clinical efficacy | N/A | The treatment started 2 days before menstrual onset, once every day and was given for 4 days for 6 menstrual cycles | 6 months |
Chen LW et al. (2006) [32] | Random number table | 30/28 | 16–28/15–24 | Acupoint application at CV 4 CV 3 CV 6 | Indometacin | Clinical efficacy | N/A | The treatment started 7 days before menstrual onset, once every day and was given for 10 days for 3 menstrual cycles | N/A |
Liu C et al. (2011) [33] | Random number table | 40/40 | 21.22 ± 5.86/20.96 ± 6.12 | Moxibustion at CV 4 EX-B8 | Fenbid | Clinical efficacy | symptom score | The treatment started 7 days before menstrual onset, once every day and was given for 10 days for 3 menstrual cycles | 3 months |
Zhu C et al. (2011) [34] | Random number table | 20/20 | 17–28/18–27 | Acupuncture at CV 4 CV 3 SP 10 SP 8 LI 4 LI 11 | Indometacin | Clinical efficacy | N/A | The treatment started 7 days before menstrual onset, once every day and was given for 7 days for 3 menstrual cycles | 3 months |
Li ZL et al. (2012) [35] | Random number table | 100/100 | 13–30/14–35 | Acupoint application at CV 3 CV 8 BL 32 SP 6 | Ibuprofen | Clinical efficacy | symptom score | The treatment started 7 days before menstrual onset, once every day and was given for 9 days for 6 menstrual cycles | 6 months |
Gurkan K et al. (2013) [19] | Registration order | 11/24 | 13.1 ± 1.0/12.8 ± 0.9 | Acupuncture at HT 7 PC 6 LI 4 LI 10 SP 6 LR 3 ST 36 GB 26 SP 15 | Naproxen sodium | N/A | VAS | The treatment was given three times on the 5th and 2nd days prior to the expected menstruation date and on the third day of menstruation for 1 month | N/A |
Jiang LY (2007) [36] | Registration order | 34/34 | 19.35 ± 4.33/20.55 ± 4.51 | Acupuncture at BL31 BL32 BL33 LI 3 SP 6 SP 8 CV 4 ST 36 | Indometacin | Clinical efficacy | N/A | The treatment started 4 days before menstrual onset, once every day and was given for 7 days for 3 menstrual cycles | N/A |
Xing QX (2011) [37] | Registration order | 60/54 | 15–27/16–32 | Pricking bloodletting at the liver area;kidney area; the liver area;the uterus area; HT 7 | Indometacin | Clinical efficacy | N/A | The treatment started during the menstrual period, once every day and was given for 3 menstrual cycles | 3 months |
Ji L et al. (2012) [38] | Random number table | 30/30 | 22 ± 3/22 ± 2 | Sandwiched moxibustion at CV 8 | Indometacin | Clinical efficacy | symptom score+ PGF2α + PGE2
| The treatment started 3 days before menstrual onset, once every day and was given for 6 days for 3 menstrual cycles | 3 months |