Background
Methods
Literature search and inclusion criteria
Data extraction and quality assessment
Statistical analysis
Results
Characteristics of included studies
First author, year | Country | Ethnicity | Age (years) Case/Control | Sample size | Genotype distribution | P-value for HWE | NOS score | |
---|---|---|---|---|---|---|---|---|
Cases Controls | ||||||||
rs1501299 G/T
| GG/GT/TT | GG/GT/TT | ||||||
Alfaqih 2018 [16] | Jordon | West Asian | 23.9/24.2 | 154/151 | 62/77/15 | 64/54/33 | 0.002 | 8 |
Czeczuga-Semeniuk 2018 [17] | Poland | Caucasian | 24.6/23.2 | 294/78 | 156/117/21 | 25/49/4 | 0.002 | 8 |
Escobar-Morreale 2006 [19] | Spain | Caucasian | NA | 76/40 | 30/39/7 | 15/21/4 | 0.390 | 7 |
Heinonen 2005 [21] | Finland | Caucasian | NA | 143/245 | 77/58/8 | 110/110/25 | 0.744 | 7 |
Li 2011 [22] | Korea | East Asian | NA | 144/159 | 61/73/10 | 48/87/24 | 0.131 | 7 |
Nambiar 2016 [23] | India | West Asian | 28.6/31.1 | 282/200 | 94/165/23 | 86/99/15 | 0.060 | 8 |
Pau 2013 [25] | USA | Mixed | NA | 525/472 | NA | NA | NA | 7 |
Radavelli-Bagatini 2013 [26] | Brazil | Mixed | NA | 80/1500 | 42/27/11 | 671/672/157 | 0.556 | 7 |
Ramezani Tehrani 2013 [27] | Iran | West Asian | 26.6/30.8 | 186/156 | 92/76/18 | 77/71/8 | 0.100 | 7 |
Ranjzad 2012 [28] | Iran | West Asian | 27.1/31.1 | 181/181 | 92/77/12 | 91/79/11 | 0.254 | 8 |
San Millán 2004 [29] | Spain | Caucasian | 24.6/31.1 | 72/42 | 28/34/10 | 18/20/4 | 0.643 | 7 |
Xita 2005 [30] | Greece | Caucasian | 23.7/24.8 | 100/140 | 39/49/12 | 52/73/15 | 0.152 | 7 |
Yoshihara 2009 [31] | Japan | East Asian | 29.1/29.8 | 38/97 | 19/15/4 | 58/24/15 | < 0.001 | 8 |
Zhang 2008 [32] | China | East Asian | 28.7/29.6 | 120/120 | 56/46/18 | 41/50/29 | 0.083 | 8 |
Zhang 2015 [33] | China | East Asian | 27.0/27.2 | 207/192 | 119/78/10 | 95/75/22 | 0.229 | 7 |
rs2241766 T/G
| TT/TG/GG | TT/TG/GG | ||||||
Alfaqih 2018 [16] | Jordon | West Asian | 23.9/24.2 | 154/149 | 92/48/14 | 93/42/14 | 0.008 | 8 |
Czeczuga-Semeniuk 2018 [17] | Poland | Caucasian | 24.6/23.2 | 294/78 | 255/39/0 | 62/16/0 | 0.313 | 8 |
Demirci 2010 [18] | Turkey | Caucasian | 24.1/23.8 | 96/93 | 70/20/6 | 74/16/3 | 0.091 | 8 |
Escobar-Morreale 2006 [19] | Spain | Caucasian | NA | 76/40 | 55/20/1 | 26/13/1 | 0.673 | 7 |
Haap 2005 [20] | Germany | Caucasian | 27.4/38.9 | 53/542 | 38/8/7 | 414/112/16 | 0.016 | 8 |
Heinonen 2005 [21] | Finland | Caucasian | NA | 143/245 | 125/17/1 | 222/22/1 | 0.572 | 7 |
Li 2011 [22] | Korea | East Asian | NA | 144/159 | 79/59/6 | 72/84/3 | < 0.001 | 7 |
Nambiar 2016 [23] | India | West Asian | 28.6/31.1 | 282/200 | 213/60/9 | 156/40/4 | 0.453 | 8 |
Panidis 2004 [24] | Greece | Caucasian | 23.4/29.4 | 132/100 | 92/33/7 | 81/17/2 | 0.340 | 7 |
Radavelli-Bagatini 2013 [26] | Brazil | Mixed | NA | 80/1500 | 64/14/2 | 1122/356/22 | 0.297 | 7 |
Ramezani Tehrani 2013 [27] | Iran | West Asian | 26.6/30.8 | 186/156 | 142/42/2 | 106/46/4 | 0.707 | 7 |
Ranjzad 2012 [28] | Iran | West Asian | 27.1/31.1 | 181/181 | 144/34/2 | 121/54/6 | 0.993 | 8 |
San Millán 2004 [29] | Spain | Caucasian | 24.6/31.1 | 72/42 | 48/22/2 | 29/12/1 | 0.853 | 7 |
Xita 2005 [30] | Greece | Caucasian | 23.7/24.8 | 100/140 | 77/23/0 | 106/30/4 | 0.306 | 7 |
Yoshihara 2009 [31] | Japan | East Asian | 29.1/29.8 | 38/97 | 19/19/0 | 53/29/15 | 0.004 | 8 |
Zhang 2008 [32] | China | East Asian | 28.7/29.6 | 120/120 | 57/54/9 | 74/42/4 | 0.504 | 8 |
Zhang 2015 [33] | China | East Asian | 27.0/27.2 | 207/192 | 106/84/17 | 98/75/19 | 0.409 | 7 |
Overall and subgroup analyses
Population | Sample size | Dominant comparison | Recessive comparison | Additive comparison | Allele comparison | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
P value | OR (95%CI) | I2 statistic | P value | OR (95%CI) | I2 statistic | P value | OR (95%CI) | I2 statistic | P value | OR (95%CI) | I2 statistic | ||
rs1501299 G/T
| GG vs. GT + TT | TT vs. GG + GT | GT vs. GG + TT | G vs. T | |||||||||
Overall | 2602/3773 | 0.10 | 1.17 (0.97–1.42) | 52% |
0.02
|
0.77 (0.62–0.95)
| 46% | 0.52 | 0.94 (0.76–1.15) | 58% |
0.001
|
1.15 (1.06–1.26)
| 43% |
Caucasian | 685/545 |
0.007
|
1.40 (1.09–1.79)
| 42% | 0.79 | 0.94 (0.62–1.45) | 0% |
0.01
|
0.73 (0.58–0.93)
| 48% |
0.03
|
1.22 (1.02–1.46)
| 22% |
East Asian | 509/568 |
0.006
|
1.41 (1.10–1.81)
| 37% |
0.0003
|
0.48 (0.32–0.71)
| 0% | 0.76 | 0.96 (0.75–1.23) | 17% |
0.0001
|
1.44 (1.20–1.73)
| 2% |
West Asian | 803/688 | 0.19 | 0.87 (0.71–1.07) | 4% | 0.88 | 0.95 (0.47–1.89) | 70% | 0.30 | 1.19 (0.85–1.68) | 62% | 0.52 | 0.95 (0.81–1.11) | 31% |
rs2241766 T/G
| TT vs. TG + GG | GG vs. TT + TG | TG vs. TT + GG | T vs. G | |||||||||
Overall | 2358/4034 | 0.63 | 1.03 (0.91–1.18) | 46% | 0.54 | 1.10 (0.81–1.50) | 41% | 0.44 | 0.95 (0.83–1.09) | 44% | 1.00 | 1.00 (0.84–1.19) | 54% |
Caucasian | 966/1280 | 0.32 | 0.89 (0.70–1.12) | 22% |
0.04
|
1.93 (1.05–3.56)
| 26% | 0.84 | 1.03 (0.80–1.31) | 6% | 0.11 | 0.84 (0.68–1.04) | 46% |
East Asian | 509/568 | 0.74 | 0.93 (0.62–1.40) | 61% | 0.86 | 1.10 (0.40–3.02) | 59% | 0.54 | 1.17 (0.71–1.93) | 73% | 0.95 | 0.99 (0.73–1.35) | 58% |
West Asian | 803/686 | 0.31 | 1.22 (0.83–1.80) | 65% | 0.56 | 0.85 (0.49–1.47) | 8% | 0.31 | 0.83 (0.59–1.18) | 53% | 0.32 | 1.19 (0.84–1.69) | 67% |