nach oben

Neurological Sciences

Erschienen in:

09.03.2019 | Original Article

Effects of aging on brain volumes in healthy individuals across adulthood

verfasst von: Iman Beheshti, Norihide Maikusa, Hiroshi Matsuda

Erschienen in: Neurological Sciences | Ausgabe 6/2019

Einloggen, um Zugang zu erhalten

Abstract

In this retrospective study, we analyzed the effects of age on brain volumes in healthy brains across adulthood. We investigated the correlations between brain volumes and age in the brains of 563 healthy individuals (age range: 20–86, 55% female) whose MRI scans and related information were drawn from the IXI database (brain-development.org/ixi-dataset/). We conducted a regression analysis to assess the effect of age on whole-brain volumes as well as selected regional volumetric measures. The whole-brain analysis revealed a negative linear relationship between gray matter (GM) and age as well as nonlinear patterns of the relationship between age and the white matter (WM), cerebrospinal fluid (CSF), and the GM/WM ratio across adulthood. The regional volumetric analysis showed linear and non-linear age-related regional volumetric changes with aging. Our present findings contribute to the understanding of how structures in the human brain change over the adult years and will help address the pathological age-related neural changes in age-related neural disorders such as Parkinson disease and Alzheimer disease.

Terribilli D, Schaufelberger MS, Duran FLS, Zanetti MV, Curiati PK, Menezes PR, Scazufca M, Amaro E Jr, Leite CC, Busatto GF (2011) Age-related gray matter volume changes in the brain during non-elderly adulthood. Neurobiol Aging 32(2):354–368CrossRefPubMedCentralPubMed

Giorgio A, Santelli L, Tomassini V, Bosnell R, Smith S, de Stefano N, Johansen-Berg H (2010) Age-related changes in grey and white matter structure throughout adulthood. Neuroimage 51(3):943–951CrossRefPubMed

Taki Y, Thyreau B, Kinomura S, Sato K, Goto R, Kawashima R, Fukuda H (2011) Correlations among brain gray matter volumes, age, gender, and hemisphere in healthy individuals. PLoS One 6(7):e22734CrossRefPubMedCentralPubMed

Sowell ER, Thompson PM, Tessner KD, Toga AW (2001) mapping continued brain growth and gray matter density reduction in dorsal frontal cortex: inverse relationships during postadolescent brain maturation. J Neurosci 21(22):8819–8829CrossRefPubMedPubMedCentral

Sowell ER, Peterson BS, Thompson PM, Welcome SE, Henkenius AL, Toga AW (2003) Mapping cortical change across the human life span. Nat Neurosci 6(3):309–315CrossRefPubMed

Resnick SM, Pham DL, Kraut MA, Zonderman AB, Davatzikos C (2003) Longitudinal magnetic resonance imaging studies of older adults: a shrinking brain. J Neurosci 23(8):3295–3301CrossRefPubMedPubMedCentral

Abe O, Yamasue H, Aoki S, Suga M, Yamada H, Kasai K, Masutani Y, Kato N, Kato N, Ohtomo K (2008) Aging in the CNS: comparison of gray/white matter volume and diffusion tensor data. Neurobiol Aging 29(1):102–116CrossRefPubMed

Kalpouzos G, Chételat G, Baron JC, Landeau B, Mevel K, Godeau C, Barré L, Constans JM, Viader F, Eustache F, Desgranges B (2009) Voxel-based mapping of brain gray matter volume and glucose metabolism profiles in normal aging. Neurobiol Aging 30(1):112–124CrossRefPubMed

Alexander GE, Chen K, Merkley TL, Reiman EM, Caselli RJ, Aschenbrenner M, Santerre-Lemmon L, Lewis DJ, Pietrini P, Teipel SJ, Hampel H, Rapoport SI, Moeller JR (2006) Regional network of magnetic resonance imaging gray matter volume in healthy aging. Neuroreport 17(10):951–956CrossRefPubMed

10.

Good CD, Johnsrude IS, Ashburner J, Henson RNA, Friston KJ, Frackowiak RSJ (2001) A voxel-based morphometric study of ageing in 465 Normal adult human brains. Neuroimage 14(1):21–36CrossRefPubMed

11.

Smith CD, Chebrolu H, Wekstein DR, Schmitt FA, Markesbery WR (2007) Age and gender effects on human brain anatomy: a voxel-based morphometric study in healthy elderly. Neurobiol Aging 28(7):1075–1087CrossRefPubMed

12.

Giorgio A, Watkins KE, Chadwick M, James S, Winmill L, Douaud G, de Stefano N, Matthews PM, Smith SM, Johansen-Berg H, James AC (2010) Longitudinal changes in grey and white matter during adolescence. Neuroimage 49(1):94–103CrossRefPubMed

13.

Matsuda H (2013) Voxel-based morphometry of brain MRI in Normal aging and Alzheimer’s disease. Aging Dis 4(1):29–37PubMed

14.

Potvin O, Dieumegarde L, Duchesne S, Initiative N (2017) NeuroImage Freesurfer cortical normative data for adults using Desikan-Killiany- Tourville and ex vivo protocols. Neuroimage 156:43–64CrossRefPubMed

15.

Potvin O, Mouiha A, Dieumegarde L, Duchesne S, Initiative ADN (2016) Normative data for subcortical regional volumes over the lifetime of the adult human brain. Neuroimage 137:9–20CrossRefPubMed

16.

Swerdlow RH (2011) Brain aging, Alzheimer’s disease, and mitochondria. Biochim Biophys Acta Mol basis Dis 1812(12):1630–1639CrossRef

17.

Reeve A, Simcox E, Turnbull D (2014) Ageing and Parkinson’s disease: why is advancing age the biggest risk factor? Ageing Res Rev 14(1):19–30CrossRefPubMedCentralPubMed

18.

Gaser C and Dahnke R (2012), “CAT - A Computational Anatomy Toolbox for the Analysis of Structural MRI Data,” vol. 32, no. 7, p. 7743

19.

Reuter M, Schmansky NJ, Rosas HD, Fischl B (2012) Within-subject template estimation for unbiased longitudinal image analysis. Neuroimage 61(4):1402–1418CrossRefPubMed

20.

Reuter M, Rosas HD, Fischl B (2010) Highly accurate inverse consistent registration: a robust approach. Neuroimage 53(4):1181–1196CrossRefPubMed

21.

Jovicich J, Czanner S, Greve D, Haley E, van der Kouwe A, Gollub R, Kennedy D, Schmitt F, Brown G, MacFall J, Fischl B, Dale A (Apr. 2006) Reliability in multi-site structural MRI studies: effects of gradient non-linearity correction on phantom and human data. Neuroimage 30(2):436–443CrossRefPubMed

22.

Ge Y, Grossman R, Babb J (2002) Age-related total gray matter and white matter changes in normal adult brain. Part I: volumetric MR imaging analysis. Am J Dent 23:1327–1333

23.

Grieve SM, Clark CR, Williams LM, Peduto AJ, Gordon E (2005) Preservation of limbic and paralimbic structures in aging. Hum Brain Mapp 25(4):391–401CrossRefPubMedPubMedCentral

24.

Farokhian F, Yang C, Beheshti I, Matsuda H, Wu S (2018) Age-related gray and white matter changes in Normal adult brains. Aging Dis 9(1):1–11CrossRef

25.

Kennedy KM, Erickson KI, Rodrigue KM, Voss MW, Colcombe SJ, Kramer AF, Acker JD, Raz N (2009) Age-related differences in regional brain volumes: a comparison of optimized voxel-based morphometry to manual volumetry. Neurobiol Aging 30(10):1657–1676CrossRefPubMed

26.

Hedden T, Gabrieli JDE (2004) Insights into the ageing mind: a view from cognitive neuroscience. Nat Rev Neurosci 5(2):87–96CrossRefPubMed

27.

Kruggel F, Turner J, Muftuler LT, Initiative ADN (2010) Impact of scanner hardware and imaging protocol on image quality and compartment volume precision in the ADNI cohort. Neuroimage 49(3):2123–2133CrossRefPubMed

28.

Han X, Jovicich J, Salat D, van der Kouwe A, Quinn B, Czanner S, Busa E, Pacheco J, Albert M, Killiany R, Maguire P, Rosas D, Makris N, Dale A, Dickerson B, Fischl B (2006) Reliability of MRI-derived measurements of human cerebral cortical thickness: {T}he effects of field strength, scanner upgrade and manufacturer. Neuroimage 32(1):180–194CrossRefPubMed

Titel: Effects of aging on brain volumes in healthy individuals across adulthood
verfasst von: Iman Beheshti
Norihide Maikusa
Hiroshi Matsuda
Publikationsdatum: 09.03.2019
Verlag: Springer International Publishing
Erschienen in: Neurological Sciences / Ausgabe 6/2019
Print ISSN: 1590-1874
Elektronische ISSN: 1590-3478
DOI: https://doi.org/10.1007/s10072-019-03817-3

Leitlinien kompakt für die Neurologie

Mit medbee Pocketcards sicher entscheiden.

^{Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag}

Kostenlos registrieren

Neu im Fachgebiet Neurologie

18.04.2024 | Arterielle Hypertonie | Nachrichten

Update Neurologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Effects of aging on brain volumes in healthy individuals across adulthood

Abstract

Leitlinien kompakt für die Neurologie

Neu im Fachgebiet Neurologie

Antihypertensiva schützen auch alte Menschen noch vor Demenz

Spinale Muskelatrophie: Neugeborenen-Screening lohnt sich

Manche Gestagene können das Risiko für Meningeome erhöhen

Parkinson: Größere Studie bestätigt Genauigkeit von Hauttest

Update Neurologie

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 6/2019

The effect of dopamine for focal hand dystonia after stroke

Methotrexate-induced toxic leukoencephalopathy: an uncommon stroke mimic

Small vessel disease and clinical outcomes after endovascular treatment in acute ischemic stroke

A novel SLC20A2 gene mutation causing primary familial brain calcification in an Ukrainian patient

Attenuation of ALS progression during pregnancy—lessons to be learned or just a coincidence?

Highlights of the issue 6, 2019

Leitlinien kompakt für die Neurologie

Neu im Fachgebiet Neurologie

Antihypertensiva schützen auch alte Menschen noch vor Demenz

Spinale Muskelatrophie: Neugeborenen-Screening lohnt sich

Manche Gestagene können das Risiko für Meningeome erhöhen

Parkinson: Größere Studie bestätigt Genauigkeit von Hauttest

Update Neurologie