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22.01.2022 | Research article

Effects of alcoholic extract of Terminalia Chebula dried fruit on blood biochemical profile in diabetic rats

verfasst von: Maha Eltimamy, Marwa Elshamarka, Marina Aboelsaad, Moustafa Sayed, Helmy Moawad

Erschienen in: Journal of Diabetes & Metabolic Disorders | Ausgabe 1/2022

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Abstract

Background

A considerable amount of attention has been recently paid to the discovery of effective natural antidiabetic drugs. Terminalia chebula is considered as the mother of herbs, with reported antidiabetic activity. This study aims to evaluate the renal and hepatic protective profile of its antidiabetic therapeutic doses.

Methods

To achieve the aim of the study, a total of 66 adult male rats of Sprague-Dawley species weighing about 180–200 g (weighed using a digital scale) were used. Type 2 diabetes mellitus (T2DM) was induced in using streptozotocin (STZ), rats were given a 5% dextrose solution for the next 24 h. Subjects received oral treatment of Terminalia chebula ethanolic extract at different doses (200, 400, and 600 mg/kg body weight) for 28 days. Measurements of fasting blood glucose level, change in body weight, lipid profile, serum liver enzymes, serum renal parameter, and histopathology of liver and kidney were carried out.

Results

Higher doses of Terminalia chebula (600 mg/Kg) were shown to have a potential therapeutic effect as well as the most prominent antidiabetic, antilipidemic activity, hepatoprotective and renoprotective profiles when compared to lower doses.

Conclusion

The use of Terminalia chebula alone or in combination with conventional antidiabetic drugs may be beneficial as a new advent therapy for diabetes.
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Literatur
3.
Zurück zum Zitat Vos T, Flaxman AD, Naghavi M, Lozano R, Michaud C, Ezzati M, et al. Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990–2010: a systematic analysis for the global burden of disease study 2010. Lancet 2012;380. Vos T, Flaxman AD, Naghavi M, Lozano R, Michaud C, Ezzati M, et al. Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990–2010: a systematic analysis for the global burden of disease study 2010. Lancet 2012;380.
7.
Zurück zum Zitat World Health Organization. Global Health estimates 2013: deaths by cause, age, sex and country, 2000–2012, WHO, Geneva, Switzerland. 2014. World Health Organization. Global Health estimates 2013: deaths by cause, age, sex and country, 2000–2012, WHO, Geneva, Switzerland. 2014.
8.
Zurück zum Zitat Diagnosis and classification of diabetes mellitus. Diabetes Care 2010;33. Diagnosis and classification of diabetes mellitus. Diabetes Care 2010;33.
9.
Zurück zum Zitat Cerf ME. Beta cell dysfunction and insulin resistance. Front Endocrinol 2013;4. Cerf ME. Beta cell dysfunction and insulin resistance. Front Endocrinol 2013;4.
10.
Zurück zum Zitat Mahmoud AM, Ahmed OM, Ashour MB, Abdel-Moneim A. In vivo and in vitro antidiabetic effects of citrus flavonoids; a study on the mechanism of action. International Journal of Diabetes in Developing Countries 2015;35. Mahmoud AM, Ahmed OM, Ashour MB, Abdel-Moneim A. In vivo and in vitro antidiabetic effects of citrus flavonoids; a study on the mechanism of action. International Journal of Diabetes in Developing Countries 2015;35.
11.
Zurück zum Zitat Diagnosis and classification of diabetes mellitus. Diabetes Care 2014;37. Diagnosis and classification of diabetes mellitus. Diabetes Care 2014;37.
12.
Zurück zum Zitat Gardner DG, MM, Shoback D, M, editors. Greenspan’s basic & clinical endocrinology. 9TH EDITION. New York: McGraw-Hill Medical; 2011. Gardner DG, MM, Shoback D, M, editors. Greenspan’s basic & clinical endocrinology. 9TH EDITION. New York: McGraw-Hill Medical; 2011.
13.
Zurück zum Zitat Kangralkar VA, Patil SD, Bandivadekar RM. Oxidative stress and diabetes: a review. Int J Pharm Appl. 2010;1(1):38–45. Kangralkar VA, Patil SD, Bandivadekar RM. Oxidative stress and diabetes: a review. Int J Pharm Appl. 2010;1(1):38–45.
14.
Zurück zum Zitat Nabi SA, Kasetti RB, Sirasanagandla S, Tilak TK, Kumar MVJ, Rao CA. Antidiabetic and antihyperlipidemic activity of Piper longum root aqueous extract in STZ induced diabetic rats. BMC Complement Altern Med 2013;13. Nabi SA, Kasetti RB, Sirasanagandla S, Tilak TK, Kumar MVJ, Rao CA. Antidiabetic and antihyperlipidemic activity of Piper longum root aqueous extract in STZ induced diabetic rats. BMC Complement Altern Med 2013;13.
15.
Zurück zum Zitat O. O. Oxidative stress in diabetes mellitus: is there a role for hypoglycemic drugs and/or antioxidants? Oxidative stress and diseases. InTech; 2012. O. O. Oxidative stress in diabetes mellitus: is there a role for hypoglycemic drugs and/or antioxidants? Oxidative stress and diseases. InTech; 2012.
16.
Zurück zum Zitat Toma A. Recent advances on novel dual-acting peroxisome proliferator-activated receptor alpha and gamma agonists. Int J Pharm Sci Res. 2013;4:1644–53. Toma A. Recent advances on novel dual-acting peroxisome proliferator-activated receptor alpha and gamma agonists. Int J Pharm Sci Res. 2013;4:1644–53.
17.
Zurück zum Zitat Cheng D, Liang B, Li Y. Antihyperglycemic effect of Ginkgo biloba extract in Streptozotocin-induced diabetes in rats. Biomed Res Int 2013;2013. Cheng D, Liang B, Li Y. Antihyperglycemic effect of Ginkgo biloba extract in Streptozotocin-induced diabetes in rats. Biomed Res Int 2013;2013.
18.
Zurück zum Zitat Germplasm Resources Information Network (GRIN). Terminalia chebula Retz. Agricultural Research Service (ARS), United States Department of Agriculture (USDA). 2016. Germplasm Resources Information Network (GRIN). Terminalia chebula Retz. Agricultural Research Service (ARS), United States Department of Agriculture (USDA). 2016.
19.
Zurück zum Zitat Kumar V, Choedon T. Medicinal plants used in the Practice of Tibetan medicine. 1st ed. GOVIL GN, editor. Studium Press, LLC, USA; 2013. Kumar V, Choedon T. Medicinal plants used in the Practice of Tibetan medicine. 1st ed. GOVIL GN, editor. Studium Press, LLC, USA; 2013.
20.
Zurück zum Zitat Dr SS. Phytochemical and Pharmacognostic study on Haritaki (Terminalia chebula Retz.). IJRAR- International Journal of Research and Analytical Reviews. 2018;5:1500–5. Dr SS. Phytochemical and Pharmacognostic study on Haritaki (Terminalia chebula Retz.). IJRAR- International Journal of Research and Analytical Reviews. 2018;5:1500–5.
21.
Zurück zum Zitat Chattopadhyay D, Naik T. Antivirals of Ethnomedicinal Origin: Structure-activity Relationship and Scope. Mini-Reviews in Medicinal Chemistry. 2007;7. Chattopadhyay D, Naik T. Antivirals of Ethnomedicinal Origin: Structure-activity Relationship and Scope. Mini-Reviews in Medicinal Chemistry. 2007;7.
22.
Zurück zum Zitat Mahesh R, Bhuvana S, Hazeena Begum VM. Effect of Terminalia chebula aqueous extract on oxidative stress and antioxidant status in the liver and kidney of young and aged rats. Cell Biochem Funct 2009;27. Mahesh R, Bhuvana S, Hazeena Begum VM. Effect of Terminalia chebula aqueous extract on oxidative stress and antioxidant status in the liver and kidney of young and aged rats. Cell Biochem Funct 2009;27.
23.
Zurück zum Zitat Kannan VR, Rajasekar GS, Rajesh P, Balasubram V, Ramesh N, Solomon EK, et al. Anti-diabetic activity on Ethanolic extracts of fruits of Terminalia chebula Retz. Alloxan Induced Diabetic Rats American Journal of Drug Discovery and Development 2012;2. Kannan VR, Rajasekar GS, Rajesh P, Balasubram V, Ramesh N, Solomon EK, et al. Anti-diabetic activity on Ethanolic extracts of fruits of Terminalia chebula Retz. Alloxan Induced Diabetic Rats American Journal of Drug Discovery and Development 2012;2.
24.
Zurück zum Zitat Akhand RN, Ahmed S, Bhowmik A, Rokeya B. Sub-chronic oral administration of the ethanolic extracts of dried Terminalia chebula mature fruits in streptozotocin (STZ)-induced type 2 diabetes mellitus (T2DM) model of long-Evans (L-E) rats improve glycemic, lipidemic and anti-oxidative status. J Appl Pharma Sci. 2013;3:027–32. Akhand RN, Ahmed S, Bhowmik A, Rokeya B. Sub-chronic oral administration of the ethanolic extracts of dried Terminalia chebula mature fruits in streptozotocin (STZ)-induced type 2 diabetes mellitus (T2DM) model of long-Evans (L-E) rats improve glycemic, lipidemic and anti-oxidative status. J Appl Pharma Sci. 2013;3:027–32.
25.
Zurück zum Zitat Borgohain R, Lahon K, Das S, Gohain K. Evaluation of mechanism of anti-diabetic activity of TERMINALIA CHEBULA on ALLOXAN and adrenaline induced diabetic albino rats. Intl J Pharma Bio Sci. 2012;3:256–66. Borgohain R, Lahon K, Das S, Gohain K. Evaluation of mechanism of anti-diabetic activity of TERMINALIA CHEBULA on ALLOXAN and adrenaline induced diabetic albino rats. Intl J Pharma Bio Sci. 2012;3:256–66.
26.
Zurück zum Zitat Lwin WW, Myint CYM, Maung M, Myint KTY. Formulation of capsule dosage form containing Ethanolic fruit extract of Terminalia chebula Retz. (Hpan-ga) having potent antioxidant activity. Myanmar Health Sci Res J. 2020;32:66–72. Lwin WW, Myint CYM, Maung M, Myint KTY. Formulation of capsule dosage form containing Ethanolic fruit extract of Terminalia chebula Retz. (Hpan-ga) having potent antioxidant activity. Myanmar Health Sci Res J. 2020;32:66–72.
27.
Zurück zum Zitat Goodarzi MO, Bryer-Ash M. Metformin revisited: re-evaluation of its properties and role in the pharmacopoeia of modern antidiabetic agents. Diabetes Obes Metab 2005;7. Goodarzi MO, Bryer-Ash M. Metformin revisited: re-evaluation of its properties and role in the pharmacopoeia of modern antidiabetic agents. Diabetes Obes Metab 2005;7.
28.
Zurück zum Zitat Nathan DM, Buse JB, Davidson MB, Ferrannini E, Holman RR, Sherwin R, et al. Medical Management of Hyperglycemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy: a consensus statement of the American Diabetes Association and the European Association for the Study of diabetes. Diabetes Care 2009;32. Nathan DM, Buse JB, Davidson MB, Ferrannini E, Holman RR, Sherwin R, et al. Medical Management of Hyperglycemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy: a consensus statement of the American Diabetes Association and the European Association for the Study of diabetes. Diabetes Care 2009;32.
29.
Zurück zum Zitat Mst. khatun M, Md. Sapon A, Md. Hossain S, Md. Islam R. ANTIDIABETIC ACTIVITY OF PIPER BETLE IN ALLOXAN INDUCED TYPE 1 DIABETIC MODEL RATS. International journal of pharmaceutical sciences and research. 2016;7:675–80. Mst. khatun M, Md. Sapon A, Md. Hossain S, Md. Islam R. ANTIDIABETIC ACTIVITY OF PIPER BETLE IN ALLOXAN INDUCED TYPE 1 DIABETIC MODEL RATS. International journal of pharmaceutical sciences and research. 2016;7:675–80.
30.
Zurück zum Zitat Moree SS, Kavishankar GB, Rajesha J. Antidiabetic effect of secoisolariciresinol diglucoside in streptozotocin-induced diabetic rats. Phytomedicine. 2013;20. Moree SS, Kavishankar GB, Rajesha J. Antidiabetic effect of secoisolariciresinol diglucoside in streptozotocin-induced diabetic rats. Phytomedicine. 2013;20.
31.
Zurück zum Zitat Liang B, Guo Z, Xie F, Zhao A. Antihyperglycemic and antihyperlipidemic activities of aqueous extract of Hericium erinaceus in experimental diabetic rats. BMC Complement Altern Med 2013;13. Liang B, Guo Z, Xie F, Zhao A. Antihyperglycemic and antihyperlipidemic activities of aqueous extract of Hericium erinaceus in experimental diabetic rats. BMC Complement Altern Med 2013;13.
32.
Zurück zum Zitat Ramachandran S, Rajasekaran A, Manisenthilkumar K. Investigation of hypoglycemic, hypolipidemic and antioxidant activities of aqueous extract of Terminalia paniculata bark in diabetic rats. Asian Pac J Trop Biomed 2012;2. Ramachandran S, Rajasekaran A, Manisenthilkumar K. Investigation of hypoglycemic, hypolipidemic and antioxidant activities of aqueous extract of Terminalia paniculata bark in diabetic rats. Asian Pac J Trop Biomed 2012;2.
33.
Zurück zum Zitat Animal models of diabetic complications consortium protocols. High dose streptozotocin induction protocol (mouse). 2009; Animal models of diabetic complications consortium protocols. High dose streptozotocin induction protocol (mouse). 2009;
34.
Zurück zum Zitat Emordi JE, Agbaje EO, Oreagba IA, Iribhogbe OI. Antidiabetic and hypolipidemic activities of hydroethanolic root extract of Uvaria chamae in streptozotocin induced diabetic albino rats. BMC Complement Altern Med 2016;16. Emordi JE, Agbaje EO, Oreagba IA, Iribhogbe OI. Antidiabetic and hypolipidemic activities of hydroethanolic root extract of Uvaria chamae in streptozotocin induced diabetic albino rats. BMC Complement Altern Med 2016;16.
35.
Zurück zum Zitat Bancroft JD, Stevens A, Turner DR, editors. Theory and PRACTICE of histological techniques. Fourth Edition. New York , London , San Francisco , Tokyo.: Churchil Livingstone ; 1996. Bancroft JD, Stevens A, Turner DR, editors. Theory and PRACTICE of histological techniques. Fourth Edition. New York , London , San Francisco , Tokyo.: Churchil Livingstone ; 1996.
36.
Zurück zum Zitat Allain CC, Poon LS, Chan CSG, Richmond W, Fu PC. Enzymatic determination of total serum cholesterol. Clin Chem. 1974;20:470–5.CrossRef Allain CC, Poon LS, Chan CSG, Richmond W, Fu PC. Enzymatic determination of total serum cholesterol. Clin Chem. 1974;20:470–5.CrossRef
37.
Zurück zum Zitat Finley PR, Tietz NW. Tietz clinical guide to laboratory tests, WB Saunders company. 4th ed: WB Saunders Company; 1996. Finley PR, Tietz NW. Tietz clinical guide to laboratory tests, WB Saunders company. 4th ed: WB Saunders Company; 1996.
38.
Zurück zum Zitat King J. The hydrolases-acid and alkaline phosphatases, in: practical clinical enzymology. (Ed.). London: Van D. Nostrand Co; 1965. King J. The hydrolases-acid and alkaline phosphatases, in: practical clinical enzymology. (Ed.). London: Van D. Nostrand Co; 1965.
39.
Zurück zum Zitat Gella FJ, Olivella T, Pastor MC, et al. A simple procedure for the routine determination of aspartate aminotransferase and alanine aminotransferase with pyridoxal phosphate. Clin Chim Acta. 1985;153:241–7.CrossRef Gella FJ, Olivella T, Pastor MC, et al. A simple procedure for the routine determination of aspartate aminotransferase and alanine aminotransferase with pyridoxal phosphate. Clin Chim Acta. 1985;153:241–7.CrossRef
40.
Zurück zum Zitat Fabiny DL, Ertingshausen G. Automated reaction-rate method for determination of serum creatinine with the CentrifiChem. Clin Chem. 1971;17:696–700.CrossRef Fabiny DL, Ertingshausen G. Automated reaction-rate method for determination of serum creatinine with the CentrifiChem. Clin Chem. 1971;17:696–700.CrossRef
41.
Zurück zum Zitat Tabacco A, Meiattini F, Moda E, Tarli P. Simplified Enzymic/colorimetric serum urea nitrogen determination. Clin Chem. 1979;25:336–7.CrossRef Tabacco A, Meiattini F, Moda E, Tarli P. Simplified Enzymic/colorimetric serum urea nitrogen determination. Clin Chem. 1979;25:336–7.CrossRef
42.
Zurück zum Zitat Bolzán AD, Bianchi MS. Genotoxicity of Streptozotocin. Mutation research/reviews in Mutat Res 2002;512. Bolzán AD, Bianchi MS. Genotoxicity of Streptozotocin. Mutation research/reviews in Mutat Res 2002;512.
43.
Zurück zum Zitat Kim C, Newton KM, Knopp RH. Gestational diabetes and the incidence of type 2 diabetes: a systematic review. Diabetes Care 2002;25. Kim C, Newton KM, Knopp RH. Gestational diabetes and the incidence of type 2 diabetes: a systematic review. Diabetes Care 2002;25.
44.
Zurück zum Zitat Kumar GPS, Arulselvan P, Kumar DS, Subramanian SP. Anti-diabetic activity of fruits of Terminalia chebula on Streptozotocin induced diabetic rats. J Health Sci 2006;52. Kumar GPS, Arulselvan P, Kumar DS, Subramanian SP. Anti-diabetic activity of fruits of Terminalia chebula on Streptozotocin induced diabetic rats. J Health Sci 2006;52.
45.
Zurück zum Zitat Brenna Ø, Qvigstad G, Brenna E, Waldum HL. Cytotoxicity of Streptozotocin on neuroendocrine cells of the pancreas and the gut. Dig Dis Sci 2003;48. Brenna Ø, Qvigstad G, Brenna E, Waldum HL. Cytotoxicity of Streptozotocin on neuroendocrine cells of the pancreas and the gut. Dig Dis Sci 2003;48.
46.
Zurück zum Zitat Abdelmeguid NE, Fakhoury R, Kamal SM, al Wafai RJ. Effects of Nigella sativa and thymoquinone on biochemical and subcellular changes in pancreatic β-cells of streptozotocin-induced diabetic rats. Journal of Diabetes. 2010;2. Abdelmeguid NE, Fakhoury R, Kamal SM, al Wafai RJ. Effects of Nigella sativa and thymoquinone on biochemical and subcellular changes in pancreatic β-cells of streptozotocin-induced diabetic rats. Journal of Diabetes. 2010;2.
47.
Zurück zum Zitat Senthilkumar GP, Subramanian SP. Biochemical studies on the effect of Terminalia chebula on the levels of glycoproteins in streptozotocin-induced experimental diabetes in rats. J Appl Biomed 2008;6. Senthilkumar GP, Subramanian SP. Biochemical studies on the effect of Terminalia chebula on the levels of glycoproteins in streptozotocin-induced experimental diabetes in rats. J Appl Biomed 2008;6.
48.
Zurück zum Zitat Murali YK, Chandra R, Murthy PS. Antihyperglycemic effect of water extract of dry fruits ofTerminalia chebula in experimental diabetes mellitus. Indian J Clin Biochem 2004;19. Murali YK, Chandra R, Murthy PS. Antihyperglycemic effect of water extract of dry fruits ofTerminalia chebula in experimental diabetes mellitus. Indian J Clin Biochem 2004;19.
49.
Zurück zum Zitat Lee H-S, Koo Y-C, Suh HJ, Kim K-Y, Lee K-W. Preventive effects of chebulic acid isolated from Terminalia chebula on advanced glycation endproduct-induced endothelial cell dysfunction. J Ethnopharmacol 2010;131. Lee H-S, Koo Y-C, Suh HJ, Kim K-Y, Lee K-W. Preventive effects of chebulic acid isolated from Terminalia chebula on advanced glycation endproduct-induced endothelial cell dysfunction. J Ethnopharmacol 2010;131.
50.
Zurück zum Zitat Kazmi D, Rabbani DrI, Rehman DrH ur, Masood DrS. Effects of terminalia chebula on blood biochemical profile and pancreatic tissue in diabetic rats. Asian J Agri Bio 2014;2:235–44. Kazmi D, Rabbani DrI, Rehman DrH ur, Masood DrS. Effects of terminalia chebula on blood biochemical profile and pancreatic tissue in diabetic rats. Asian J Agri Bio 2014;2:235–44.
51.
Zurück zum Zitat Ewenighi C, Dimkpa U, Onyeanusi J, Onoh L, Onoh G, Ezeugwu U. Estimation of glucose level and body weight in Alloxan induced diabetic rat treated with aqueous extract of Garcinia Kola seed. The Ulutas Medical J 2015;1. Ewenighi C, Dimkpa U, Onyeanusi J, Onoh L, Onoh G, Ezeugwu U. Estimation of glucose level and body weight in Alloxan induced diabetic rat treated with aqueous extract of Garcinia Kola seed. The Ulutas Medical J 2015;1.
52.
Zurück zum Zitat Zafar M, Naeem-ul-Hassan Naqvi S. Effects of STZ-induced diabetes on the relative weights of kidney, liver and pancreas in albino rats: a comparative study. Int J Morphol 2010;28. Zafar M, Naeem-ul-Hassan Naqvi S. Effects of STZ-induced diabetes on the relative weights of kidney, liver and pancreas in albino rats: a comparative study. Int J Morphol 2010;28.
53.
Zurück zum Zitat Goodman L, Gilman A. The pharmacological basis of therapeutics. 7th ed. New York: Macmillan; 1985. Goodman L, Gilman A. The pharmacological basis of therapeutics. 7th ed. New York: Macmillan; 1985.
54.
Zurück zum Zitat Mitra SK, Gopumadhavan S, Muralidhar TS, Anturlikar SD, Sujatha MB. Effect of D-400, a herbomineral preparation on lipid profile, glycated haemoglobin and glucose tolerance in streptozotocin induced diabetes in rats. Indian J Exp Biol. 1995;33:798–800.PubMed Mitra SK, Gopumadhavan S, Muralidhar TS, Anturlikar SD, Sujatha MB. Effect of D-400, a herbomineral preparation on lipid profile, glycated haemoglobin and glucose tolerance in streptozotocin induced diabetes in rats. Indian J Exp Biol. 1995;33:798–800.PubMed
55.
Zurück zum Zitat Ravi K, Rajasekaran S, Subramanian S. Antihyperlipidemic effect of Eugenia jambolana seed kernel on streptozotocin-induced diabetes in rats. Food Chem Toxicol 2005;43. Ravi K, Rajasekaran S, Subramanian S. Antihyperlipidemic effect of Eugenia jambolana seed kernel on streptozotocin-induced diabetes in rats. Food Chem Toxicol 2005;43.
56.
Zurück zum Zitat Yadav UCS, Moorthy K, Baquer NZ. Combined treatment of sodium orthovanadate and Momordica charantia fruit extract prevents alterations in lipid profile and lipogenic enzymes in alloxan diabetic rats. Mol Cell Biochem 2005;268. Yadav UCS, Moorthy K, Baquer NZ. Combined treatment of sodium orthovanadate and Momordica charantia fruit extract prevents alterations in lipid profile and lipogenic enzymes in alloxan diabetic rats. Mol Cell Biochem 2005;268.
57.
Zurück zum Zitat Al-Attar AM. Physiological effects of some plant oils supplementation on Streptozotocin-induced diabetic rats. Res J Med Med Sci. 2010;5:55–70. Al-Attar AM. Physiological effects of some plant oils supplementation on Streptozotocin-induced diabetic rats. Res J Med Med Sci. 2010;5:55–70.
58.
Zurück zum Zitat Rathore H, Soni S, Bhatnagar D. Hypocholesterolemic effect of Terminalia chebula fruit (Myrobalan) in mice. Anc Sci Life. 2004;23. Rathore H, Soni S, Bhatnagar D. Hypocholesterolemic effect of Terminalia chebula fruit (Myrobalan) in mice. Anc Sci Life. 2004;23.
59.
Zurück zum Zitat Pederson BA, Schroeder JM, Parker GE, Smith MW, DePaoli-Roach AA, Roach PJ. Glucose metabolism in mice lacking muscle glycogen synthase. Diabetes. 2005;54. Pederson BA, Schroeder JM, Parker GE, Smith MW, DePaoli-Roach AA, Roach PJ. Glucose metabolism in mice lacking muscle glycogen synthase. Diabetes. 2005;54.
60.
Zurück zum Zitat Juza RM, Pauli EM. Clinical and surgical anatomy of the liver: A review for clinicians. Clinical Anatomy. 2014;27. Juza RM, Pauli EM. Clinical and surgical anatomy of the liver: A review for clinicians. Clinical Anatomy. 2014;27.
61.
Zurück zum Zitat Elgazar AF, Rezq AA, Bukhari HM. Anti-hyperglycemic effect of saffron extract in Alloxan-induced diabetic rats. Eur J Biol Sci. 2013;5:14–22. Elgazar AF, Rezq AA, Bukhari HM. Anti-hyperglycemic effect of saffron extract in Alloxan-induced diabetic rats. Eur J Biol Sci. 2013;5:14–22.
62.
Zurück zum Zitat Menon N, Sparks J, Omoruyi F. Hypoglycemic and hypocholesterolemic activities of the aqueous preparation of Kalanchoe pinnata leaves in streptozotocin-induced diabetic rats. Asian Pac J Trop Biomed 2015;5. Menon N, Sparks J, Omoruyi F. Hypoglycemic and hypocholesterolemic activities of the aqueous preparation of Kalanchoe pinnata leaves in streptozotocin-induced diabetic rats. Asian Pac J Trop Biomed 2015;5.
63.
Zurück zum Zitat Collins AJ, Foley RN, Chavers B, Gilbertson D, Herzog C, Johansen K, et al. US Renal Data System 2011 Annual Data Report. Am J Kidney Dis 2012;59. Collins AJ, Foley RN, Chavers B, Gilbertson D, Herzog C, Johansen K, et al. US Renal Data System 2011 Annual Data Report. Am J Kidney Dis 2012;59.
64.
Zurück zum Zitat Thiruchelvi R, Arul D, Meenakshi S, Subramanian K. Protective effects of Terminalia Chebula fruit extract against cadmium-induced nephrotoxicity in rats. International J Environ Biol 2012; Thiruchelvi R, Arul D, Meenakshi S, Subramanian K. Protective effects of Terminalia Chebula fruit extract against cadmium-induced nephrotoxicity in rats. International J Environ Biol 2012;
65.
Zurück zum Zitat Negm SH, El-Soadaa SS. Effect of Terminalia chebula on cadmium-induced nephrotoxicity and lipid profiles in rats. Biosci Res. 2020;17:1535–44. Negm SH, El-Soadaa SS. Effect of Terminalia chebula on cadmium-induced nephrotoxicity and lipid profiles in rats. Biosci Res. 2020;17:1535–44.
66.
Zurück zum Zitat Muneer A, Alhowail A, Aldubayan M, Rabbani SI. The activity of Terminalia chebula Retz. Extract on doxorubicininduced renal damage in rats. J Pharm Pharmacog Res. 2020;8:237–46. Muneer A, Alhowail A, Aldubayan M, Rabbani SI. The activity of Terminalia chebula Retz. Extract on doxorubicininduced renal damage in rats. J Pharm Pharmacog Res. 2020;8:237–46.
Metadaten
Titel
Effects of alcoholic extract of Terminalia Chebula dried fruit on blood biochemical profile in diabetic rats
verfasst von
Maha Eltimamy
Marwa Elshamarka
Marina Aboelsaad
Moustafa Sayed
Helmy Moawad
Publikationsdatum
22.01.2022
Verlag
Springer International Publishing
Erschienen in
Journal of Diabetes & Metabolic Disorders / Ausgabe 1/2022
Elektronische ISSN: 2251-6581
DOI
https://doi.org/10.1007/s40200-021-00951-8

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