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01.12.2018 | Research article | Ausgabe 1/2018 Open Access

BMC Public Health 1/2018

Effects of alternate day calorie restriction and exercise on cardio-metabolic risk factors in overweight and obese adults: an exploratory randomized controlled study

Zeitschrift:
BMC Public Health > Ausgabe 1/2018
Autoren:
Minsuk Oh, Sue Kim, Ki-Yong An, Jihee Min, Hyuk In Yang, Junga Lee, Mi Kyung Lee, Dong-Il Kim, Hye-Sun Lee, Ji-Won Lee, Justin Y. Jeon
Wichtige Hinweise

Electronic supplementary material

The online version of this article (https://​doi.​org/​10.​1186/​s12889-018-6009-1) contains supplementary material, which is available to authorized users.

Abstract

Background

It has been recognized that alternate day calorie restriction (ADCR) or exercise has positive effects on cardio-metabolic risk factors. It is unclear whether the combined effect of ADCR and exercise (aerobic + resistance training) influences risk. We investigated effects of an 8-week ADCR and exercise program (aerobic + resistance training) on cardio-metabolic risk factors in overweight and obese adults.

Methods

This study randomized 45 overweight or obese but healthy adults (F = 26, M = 19; aged about 32 to 40 years) into 4 groups: ADCR (n = 13), exercise (n = 10), exercise plus ADCR (n = 12), and control (n = 10) for 8 weeks. Body composition, blood lipids profile, and insulin resistance were measured. The intention to treat (ITT) method was used to analyze all participants that were randomized.

Results

A total of 35 participants completed the trial (78%). Body weight, body mass index, waist circumference, fat mass and percent body fat were reduced in the exercise plus ADCR group (− 3.3 ± 2.4 kg, p < 0.01; − 1.3 ± 1.0 kg/m2, p < 0.01; − 4.1 ± 3.9 cm, p < 0.01; − 2.7 ± 2.0 kg, p < 0.01; − 2. 5 ± 2.2%, p < 0.01). Insulin, glucose, homeostasis model assessment insulin resistance and triglyceride (− 2.9 ± 4.1 μIU/ml, p < 0.05; − 10.9 ± 16.9 mg/dl, p < 0.05; − 0.9 ± 1.3, p < 0.05; − 43.8 ± 41.9 mg/dl, p < 0.01) decreased in the exercise plus ADCR group only.

Conclusions

ADCR and exercise both proved to be beneficial, but the combined intervention was most effective at inducing beneficial changes in body weight, body composition, glucose, insulin, insulin resistance and triglyceride in overweight and obese adults.

Trial registration

ClinicalTrials.gov: NCT03652532, Registered August 28, 2018, ‘retrospectively registered’.
Zusatzmaterial
Additional file 1: Table S1. Effect of intervention on anthropometric and body measurements (PP). Table S2. Effect of intervention on blood lipids and insulin resistance (PP). (DOCX 26 kb)
12889_2018_6009_MOESM1_ESM.docx
Literatur
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