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Erschienen in: Forensic Toxicology 1/2019

01.01.2019 | Original Article

Effects of aromatic ring-substituted phenethylamines on the release of dopamine and serotonin

verfasst von: Minjeong Kim, Chae Ha Yang, Yong Sup Lee, Choon-Gon Jang, Seikwan Oh, Sooyeun Lee

Erschienen in: Forensic Toxicology | Ausgabe 1/2019

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Abstract

Purpose

Significant disturbances of the classical amphetamines on the dopamine (DA) and serotonin (5-HT) systems have been previously reported. However, few studies have been conducted on the effects of new psychoactive phenethylamines on the release of DA and 5-HT. In the present study, the effects of new psychoactive phenethylamines with a variety of aromatic ring substitutions (5-API, 3-FMA, 5-MAPB, and DMMA) on the release of DA and 5-HT were investigated.

Methods

Changes of DA, 5-HT and their metabolites in brain microdialysates from rats following exposure to the drugs were examined using a validated liquid chromatography–tandem mass spectrometry method. Their potencies of DA and 5-HT uptake inhibition as well as dopamine transporter (DAT) and serotonin transporter (SERT) binding were also determined.

Results

With the exception of DMMA, the drugs markedly affected the extracellular concentration of DA, 5-HT and/or their metabolites in rats and acted as potent inhibitors for DAT and/or SERT.  Especially, 5-API potently induced the nonselective release of both DA and 5-HT, which was strongly correlated with a high degree of uptake inhibition and binding affinity to DAT and SERT. The 3-FMA, a methamphetamine analog with a halogen-substituted benzene, induced greater 5-HT release than DA.

Conclusions

We found that new psychoactive phenethylamines, with a variety of aromatic ring substitutions, affected the extracellular levels of DA, 5-HT, and/or their metabolites in the nucleus accumbens of rats to varying degrees and in different ways. The current results may assist further research into monoamine neurotransmitter-related mechanisms of new psychoactive phenethylamines.

Graphical abstract

Literatur
5.
Zurück zum Zitat Gingrich JA, Hen R (2001) Dissecting the role of the serotonin system in neuropsychiatric disorders using knockout mice. Psychopharmacology 155:1–10 (PMID: 11374326) CrossRefPubMed Gingrich JA, Hen R (2001) Dissecting the role of the serotonin system in neuropsychiatric disorders using knockout mice. Psychopharmacology 155:1–10 (PMID: 11374326) CrossRefPubMed
6.
Zurück zum Zitat Sanders-Bush E, Hazelwood L (2011) 5-Hydroxytryptamine (serotonin) and dopamine. In: Brunton LL, Chabner BA, Knollmann BC (eds) Goodman & Gilman’s pharmacological basis of therapeutics, 12th edn. McGraw-Hill, New York, pp 335–361 Sanders-Bush E, Hazelwood L (2011) 5-Hydroxytryptamine (serotonin) and dopamine. In: Brunton LL, Chabner BA, Knollmann BC (eds) Goodman & Gilman’s pharmacological basis of therapeutics, 12th edn. McGraw-Hill, New York, pp 335–361
8.
Zurück zum Zitat Lyles J, Cadet JL (2003) Methylenedioxymethamphetamine (MDMA, Ecstasy) neurotoxicity: cellular and molecular mechanisms. Brain Res Rev 42:155–168 (PMID: 12738056) CrossRefPubMed Lyles J, Cadet JL (2003) Methylenedioxymethamphetamine (MDMA, Ecstasy) neurotoxicity: cellular and molecular mechanisms. Brain Res Rev 42:155–168 (PMID: 12738056) CrossRefPubMed
13.
Zurück zum Zitat Torres GE, Yao WD, Mohn AR, Quan H, Kim KM, Levey AI, Staudinger J, Caron MG (2001) Functional interaction between monoamine plasma membrane transporters and the synaptic PDZ domain-containing protein PICK1. Neuron 30:121–134 (PMID: 11343649) CrossRefPubMed Torres GE, Yao WD, Mohn AR, Quan H, Kim KM, Levey AI, Staudinger J, Caron MG (2001) Functional interaction between monoamine plasma membrane transporters and the synaptic PDZ domain-containing protein PICK1. Neuron 30:121–134 (PMID: 11343649) CrossRefPubMed
Metadaten
Titel
Effects of aromatic ring-substituted phenethylamines on the release of dopamine and serotonin
verfasst von
Minjeong Kim
Chae Ha Yang
Yong Sup Lee
Choon-Gon Jang
Seikwan Oh
Sooyeun Lee
Publikationsdatum
01.01.2019
Verlag
Springer Japan
Erschienen in
Forensic Toxicology / Ausgabe 1/2019
Print ISSN: 1860-8965
Elektronische ISSN: 1860-8973
DOI
https://doi.org/10.1007/s11419-018-0440-y

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