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01.12.2012 | Original investigation | Ausgabe 1/2012 Open Access

Cardiovascular Diabetology 1/2012

Effects of bezafibrate on lipid and glucose metabolism in dyslipidemic patients with diabetes: the J-BENEFIT study

Zeitschrift:
Cardiovascular Diabetology > Ausgabe 1/2012
Autoren:
Tamio Teramoto, Kohji Shirai, Hiroyuki Daida, Nobuhiro Yamada
Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1186/​1475-2840-11-29) contains supplementary material, which is available to authorized users.

Competing interests

This work was sponsored by KISSEI Pharmaceutical Company, Japan. TT is currently an active member of the GlaxoSmithKline KK scientific advisory board. TT has received research grants from Daiichi-Sankyo Co. Ltd., Astellas Pharma Inc., Kowa Co. Ltd., Shionogi Co. Ltd., Bayer Yakuhin Ltd. and Kissei Pharmaceutical Co. Ltd. KS has received research grants from Daichi Sankyo Co. Ltd., Astellas Pharma Inc., Ohtsuka Pharmaceutical Company, Kowa Co. Ltd., Kissei Pharmaceutical Co. Ltd., Banyu Pharmaceutical Co. Ltd. and Fukuda Denshi Co. Ltd. and has received honoraria as a lecturer from Kowa Co. Ltd., Daiichi Sankyo Co. Ltd., Sunny Health Co. Ltd., Takeda Pharmaceutical Co. Ltd., Fukuda Densi Co. Ltd., and Shionogi Pharmaceutical Co. Ltd. HD is an advisory member of Kowa Co. Ltd. and Sanofi-Aventis KK and has received honoraria for lectures and research grants from Kowa Co. Ltd., Pfizer Inc., Daiichi Sankyo Co. Ltd., AstraZeneca PLC, Astellas Pharma Inc., The Boston Scientific Corporation, Sanofi-aventis KK, Mochida Pharmaceutical Co. Ltd., Takeda Pharmaceutical Co. Ltd. and Dainippon Sumitomo Pharma Co. Ltd.

Authors' contributions

KS participated in drafting the manuscript. HD performed the statistical analysis. NY participated in the design of the study. TT conceived of the study and participated in its design and coordination and helped draft the manuscript. All authors read and approved the final manuscript.

Abstract

Background

The hypoglycemic effect of bezafibrate is well established, but administration to a large population of patients with diabetes has not been reported. We investigated glycemic control, relationship between lipid metabolism and HbA1c, and safety in diabetic patients treated with bezafibrate.

Methods

A prospective, observational analysis was conducted on 6,407 dyslipidemic patients suffering from diabetes or hyperglycemia who had not received bezafibrate previously. Subanalyses were performed on the concomitant use of diabetes drugs, diabetes duration, and baseline HbA1c levels.

Results

Bezafibrate significantly decreased HbA1c irrespective of concomitant use of other diabetes drugs in a baseline-HbA1c-dependent manner, with patients with a shorter diabetes duration showing a greater decrease in HbA1c than those with longer-term disease. The rate of change in triglyceride levels was significantly associated with that in HbA1c. Adverse drug reactions occurred in 306 patients (5.1%), of which reactions in 289 were not severe (94.4%).

Conclusions

Bezafibrate significantly improved HbA1c in patients with diabetes given individualized treatment. Bezafibrate may offer clinicians an improved modality for the amelioration of disease course and improvement of outcome in these patients.
Zusatzmaterial
Authors’ original file for figure 1
12933_2011_451_MOESM1_ESM.jpeg
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