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Current Nutrition Reports
Erschienen in:

06.09.2024 | REVIEW

Effects of Caloric Restriction and Intermittent Fasting and Their Combined Exercise on Cognitive Functioning: A Review

verfasst von: Junming Wang, Yifeng Rang, Chunhong Liu

Erschienen in: Current Nutrition Reports | Ausgabe 4/2024

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Abstract

Purpose of Review

The impact of dietary habits on cognitive function is increasingly gaining attention. The review is to discuss how caloric restriction (CR) and intermittent fasting (IF) can enhance cognitive function in healthy states through multiple pathways that interact with one another. Secondly, to explore the effects of CR and IF on cognitive function in conditions of neurodegenerative diseases, obesity diabetes and aging, as well as potential synergistic effects in combination with exercise to prevent cognitively related neurodegenerative diseases.

Recent Findings

With age, the human brain ages and develops corresponding neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and epilepsy, which in turn trigger cognitive impairment. Recent research indicates that the impact of diet and exercise on cognitive function is increasingly gaining attention.

Summary

The benefits of exercise for cognitive function and brain plasticity are numerous, and future research can examine the efficacy of particular dietary regimens during physical activity when combined with diet which can prevent cognitive decline.
Literatur
1.
2.
3.
Martin B, Mattson MP, Maudsley S. Caloric restriction and intermittent fasting: Two potential diets for successful brain aging. Ageing Res Rev. 2006;5:332–53.PubMedPubMedCentralCrossRef
4.
Spuch C, Navarro C. Liposomes for Targeted Delivery of Active Agents against Neurodegenerative Diseases (Alzheimer’s Disease and Parkinson’s Disease). J Drug Deliv. 2011;2011:1–12.CrossRef
5.
Adlimoghaddam A, Neuendorff M, Roy B, Albensi BC. A review of clinical treatment considerations of donepezil in severe Alzheimer’s disease. CNS Neurosci Ther. 2018;24:876–88.PubMedPubMedCentralCrossRef
6.
7.
Yu Q, Zou L, Kong Z, Yang L. Cognitive Impact of Calorie Restriction: A Narrative Review. J Am Med Dir Assoc. 2020;21:1394–401.PubMedCrossRef
8.
Schafer MJ, Dolgalev I, Alldred MJ, Heguy A, Ginsberg SD. Calorie Restriction Suppresses Age-Dependent Hippocampal Transcriptional Signatures. Anderson RM, editor. PLoS ONE. 2015;10:e0133923.
9.
Cherif A, Roelands B, Meeusen R, Chamari K. Effects of Intermittent Fasting, Caloric Restriction, and Ramadan Intermittent Fasting on Cognitive Performance at Rest and During Exercise in Adults. Sports Med. 2016;46:35–47.PubMedCrossRef
10.
11.
Singh R, Lakhanpal D, Kumar S, Sharma S, Kataria H, Kaur M, et al. Late-onset intermittent fasting dietary restriction as a potential intervention to retard age-associated brain function impairments in male rats. Age. 2012;34:917–33.PubMedCrossRef
12.
Lee J, Duan W, Mattson MP. Evidence that brain-derived neurotrophic factor is required for basal neurogenesis and mediates, in part, the enhancement of neurogenesis by dietary restriction in the hippocampus of adult mice. J Neurochem. 2002;82:1367–75.PubMedCrossRef
13.
Wu A, Sun X, Liu Y. Effects of caloric restriction on cognition and behavior in developing mice. Neurosci Lett. 2003;339(2):166–8.PubMedCrossRef
14.
Willcox DC, Willcox BJ, Todoriki H, Curb JD, Suzuki M. Caloric restriction and human longevity: what can we learn from the Okinawans? Biogerontology. 2006;7:173–7.PubMedCrossRef
15.
Leclerc E, Trevizol AP, Grigolon RB, Subramaniapillai M, McIntyre RS, Brietzke E, et al. The effect of caloric restriction on working memory in healthy non-obese adults. CNS Spectr. 2020;25:2–8.PubMedCrossRef
16.
Witte AV, Fobker M, Gellner R, Knecht S, Flöel A. Caloric restriction improves memory in elderly humans. Proc Natl Acad Sci USA. 2009;106:1255–60.PubMedPubMedCentralCrossRef
17.
18.
Fenneni MA, Latiri I, Aloui A, Rouatbi S, Saafi MA, Bougmiza I, et al. Effects of Ramadan on physical capacities of North African boys fasting for the first time. Libyan J Med. 2014;9:25391.PubMedCrossRef
19.
Michalsen A, Li C. Fasting Therapy for Treating and Preventing Disease - Current State of Evidence. Complement Med Res. 2013;20:444–53.CrossRef
20.
21.
Li L, Wang Z, Zuo Z. Chronic Intermittent Fasting Improves Cognitive Functions and Brain Structures in Mice. Xie Z, editor. PLoS ONE. 2013;8:e66069.
22.
Zheng H, Ton H, Yang L, Liufu N, Dong Y, Zhang Y, et al. Acute Fasting Does Not Induce Cognitive Impairment in Mice. Front Neurosci. 2019;13:896.PubMedPubMedCentralCrossRef
23.
Mattson MP, Longo VD, Harvie M. Impact of intermittent fasting on health and disease processes. Ageing Res Rev. 2017;39:46–58.PubMedCrossRef
24.
Currenti W, Godos J, Castellano S, Mogavero MP, Ferri R, Caraci F, et al. Time restricted feeding and mental health: a review of possible mechanisms on affective and cognitive disorders. Int J Food Sci Nutr. 2021;72:723–33.PubMedCrossRef
25.
Murray AJ, Knight NS, Cole MA, Cochlin LE, Carter E, Tchabanenko K, et al. Novel ketone diet enhances physical and cognitive performance. FASEB J. 2016;30:4021–32.PubMedPubMedCentralCrossRef
26.
27.
28.
Müller L, Power Guerra N, Stenzel J, Rühlmann C, Lindner T, Krause BJ, et al. Long-Term Caloric Restriction Attenuates β-Amyloid Neuropathology and Is Accompanied by Autophagy in APPswe/PS1delta9 Mice. Nutrients. 2021;13:985.PubMedPubMedCentralCrossRef
29.
Ntsapi CM, Loos B. Neurons die with heightened but functional macro- and chaperone mediated autophagy upon increased amyloid-ß induced toxicity with region-specific protection in prolonged intermittent fasting. Exp Cell Res. 2021;408: 112840.PubMedCrossRef
30.
Alirezaei M, Kemball CC, Flynn CT, Wood MR, Whitton JL, Kiosses WB. Short-term fasting induces profound neuronal autophagy. Autophagy. 2010;6:702–10.PubMedPubMedCentralCrossRef
31.
Srivastava SC, Haigis M. Role of Sirtuins and Calorie Restriction in Neuroprotection: Implications in Alzheimers and Parkinsons Diseases. Curr Pharm Des. 2011;17:3418–33.PubMedCrossRef
32.
Mattson MP. Interventions that Improve Body and Brain Bioenergetics for Parkinson’s Disease Risk Reduction and Therapy. J Parkinson’s Dis. 2014;4:1–13.CrossRef
33.
Maswood N, Young J, Tilmont E, Zhang Z, Gash DM, Gerhardt GA, et al. Caloric restriction increases neurotrophic factor levels and attenuates neurochemical and behavioral deficits in a primate model of Parkinson’s disease. Proc Natl Acad Sci USA. 2004;101:18171–6.PubMedPubMedCentralCrossRef
34.
Coppens J, Bentea E, Bayliss J, Demuyser T, Walrave L, Albertini G, et al. Caloric Restriction Protects against Lactacystin-Induced Degeneration of Dopamine Neurons Independent of the Ghrelin Receptor. IJMS. 2017;18:558.PubMedPubMedCentralCrossRef
35.
Ojha U, Khanal S, Park P-H, Hong JT, Choi D-Y. Intermittent fasting protects the nigral dopaminergic neurons from MPTP-mediated dopaminergic neuronal injury in mice. J Nutr Biochem. 2023;112: 109212.PubMedCrossRef
36.
Freeman LR, Haley-Zitlin V, Rosenberger DS, Granholm A-C. Damaging effects of a high-fat diet to the brain and cognition: A review of proposed mechanisms. Nutr Neurosci. 2014;17:241–51.PubMedCrossRef
37.
Khan NA, Raine LB, Donovan SM, Hillman CH IV. The Cognitive Implications Of Obesity And Nutrition In Childhood. Monographs Society Res Child. 2014;79:51–71.CrossRef
38.
Yilmaz N, Vural H, Yilmaz M, Sutcu R, Sirmali R, Hicyilmaz H, et al. Calorie restriction modulates hippocampal NMDA receptors in diet-induced obese rats. J Recept Signal Transduct Res. 2011;31:214–9.PubMedCrossRef
39.
Kim H, Kang H, Heo RW, Jeon BT, Yi C, Shin HJ, et al. Caloric restriction improves diabetes-induced cognitive deficits by attenuating neurogranin-associated calcium signaling in high-fat diet-fed mice. J Cereb Blood Flow Metab. 2016;36:1098–110.PubMedCrossRef
40.
Ebrahim HA, El-Gamal R, Sherif RN. Intermittent Fasting Attenuates High-Fat Diet-Induced Cerebellar Changes in Rats: Involvement of TNF-α, Autophagy, and Oxidative Stress. Cells Tissues Organs. 2021;210:351–67.PubMedCrossRef
41.
Solianik R, Sujeta A, Čekanauskaitė A. Effects of 2-day calorie restriction on cardiovascular autonomic response, mood, and cognitive and motor functions in obese young adult women. Exp Brain Res. 2018;236:2299–308.PubMedCrossRef
42.
Solianik R, Sujeta A. Two-day fasting evokes stress, but does not affect mood, brain activity, cognitive, psychomotor, and motor performance in overweight women. Behav Brain Res. 2018;338:166–72.PubMedCrossRef
43.
Teong XT, Hutchison AT, Liu B, Wittert GA, Lange K, Banks S, et al. Eight weeks of intermittent fasting versus calorie restriction does not alter eating behaviors, mood, sleep quality, quality of life and cognitive performance in women with overweight. Nutr Res. 2021;92:32–9.PubMedCrossRef
44.
Anton SD, Lee SA, Donahoo WT, McLaren C, Manini T, Leeuwenburgh C, et al. The Effects of Time Restricted Feeding on Overweight Older Adults: A Pilot Study. Nutrients. 2019;11:1500.PubMedPubMedCentralCrossRef
45.
Stanek A, Brożyna-Tkaczyk K, Zolghadri S, Cholewka A, Myśliński W. The Role of Intermittent Energy Restriction Diet on Metabolic Profile and Weight Loss among Obese Adults. Nutrients. 2022;14:1509.PubMedPubMedCentralCrossRef
46.
Coker LH, Shumaker SA. Type 2 diabetes mellitus and cognition An understudied issue in women’s health. J Psychosom Res. 2003;54(2):129–39.PubMedCrossRef
47.
Biessels GJ. Caffeine, Diabetes, Cognition, and Dementia. Cunha RA, De Mendonça A, editors. JAD. 2010;20:S143–50.
48.
49.
50.
Farzi A, Hassan AM, Zenz G, Holzer P. Diabesity and mood disorders: Multiple links through the microbiota-gut-brain axis. Mol Aspects Med. 2019;66:80–93.PubMedCrossRef
51.
52.
Liu Z, Dai X, Zhang H, Shi R, Hui Y, Jin X, et al. Gut microbiota mediates intermittent-fasting alleviation of diabetes-induced cognitive impairment. Nat Commun. 2020;11:855.PubMedPubMedCentralCrossRef
53.
Elesawy BH, Raafat BM, Muqbali AA, Abbas AM, Sakr HF. The Impact of Intermittent Fasting on Brain-Derived Neurotrophic Factor, Neurotrophin 3, and Rat Behavior in a Rat Model of Type 2 Diabetes Mellitus. Brain Sci. 2021;11:242.PubMedPubMedCentralCrossRef
54.
Ugochukwu NH, Mukes JD, Figgers CL. Ameliorative effects of dietary caloric restriction on oxidative stress and inflammation in the brain of streptozotocin-induced diabetic rats. Clin Chim Acta. 2006;370:165–73.PubMedCrossRef
55.
Parr EB, Devlin BL, Lim KHC, Moresi LNZ, Geils C, Brennan L, et al. Time-Restricted Eating as a Nutrition Strategy for Individuals with Type 2 Diabetes: A Feasibility Study. Nutrients. 2020;12:3228.PubMedPubMedCentralCrossRef
56.
Sutton EF, Beyl R, Early KS, Cefalu WT, Ravussin E, Peterson CM. Early Time-Restricted Feeding Improves Insulin Sensitivity, Blood Pressure, and Oxidative Stress Even without Weight Loss in Men with Prediabetes. Cell Metab. 2018;27:1212-1221.e3.PubMedPubMedCentralCrossRef
57.
Pearce KL, Noakes M, Wilson C, Clifton PM. Continuous Glucose Monitoring and Cognitive Performance in Type 2 Diabetes. Diabetes Technol Ther. 2012;14:1126–33.PubMedCrossRef
58.
Seidler K. Intermittent fasting and cognitive performance – Targeting BDNF as potential strategy to optimise brain health. Front Neuroendocrinol. 2022;65:100971.PubMedCrossRef
59.
Liu R, Liu IY, Bi X, Thompson RF, Doctrow SR, Malfroy B, et al. Reversal of age-related learning deficits and brain oxidative stress in mice with superoxide dismutase/catalase mimetics. Proc Natl Acad Sci USA. 2003;100:8526–31.PubMedPubMedCentralCrossRef
60.
Singh R, Manchanda S, Kaur T, Kumar S, Lakhanpal D, Lakhman SS, et al. Middle age onset short-term intermittent fasting dietary restriction prevents brain function impairments in male Wistar rats. Biogerontology. 2015;16:775–88.PubMedCrossRef
61.
Zhao Y, Jia M, Chen W, Liu Z. The neuroprotective effects of intermittent fasting on brain aging and neurodegenerative diseases via regulating mitochondrial function. Free Radical Biol Med. 2022;182:206–18.CrossRef
62.
Yang F, Chu X, Yin M, Liu X, Yuan H, Niu Y, et al. mTOR and autophagy in normal brain aging and caloric restriction ameliorating age-related cognition deficits. Behav Brain Res. 2014;264:82–90.CrossRef
63.
Lin A-L, Coman D, Jiang L, Rothman DL, Hyder F. Caloric Restriction Impedes Age-Related Decline of Mitochondrial Function and Neuronal Activity. J Cereb Blood Flow Metab. 2014;34:1440–3.PubMedPubMedCentralCrossRef
64.
Pronk NP. Neuroplasticity and the role of exercise and diet on cognition. Am J Clin Nutr. 2021;113:1392–3.PubMedCrossRef
65.
Komulainen P, Tuomilehto J, Savonen K, Männikkö R, Hassinen M, Lakka TA, et al. Exercise, diet, and cognition in a 4-year randomized controlled trial: Dose-Responses to Exercise Training (DR’s EXTRA). Am J Clin Nutr. 2021;113:1428–39.PubMedPubMedCentralCrossRef
66.
Marosi K, Mattson MP. BDNF mediates adaptive brain and body responses to energetic challenges. Trends Endocrinol Metab. 2014;25:89–98.PubMedCrossRef
67.
Gibbons TD, Cotter JD, Ainslie PN, Abraham WC, Mockett BG, Campbell HA, et al. Fasting for 20 h does not affect exercise-induced increases in circulating BDNF in humans. J Physiol. 2023;601:2121–37.PubMedCrossRef
68.
Khabour OF, Alzoubi KH, Alomari MA, Alzubi MA. Changes in spatial memory and BDNF expression to concurrent dietary restriction and voluntary exercise. Hippocampus. 2010;20:637–45.PubMedCrossRef
69.
Cheng A, Wan R, Yang J-L, Kamimura N, Son TG, Ouyang X, et al. Involvement of PGC-1α in the formation and maintenance of neuronal dendritic spines. Nat Commun. 2012;3:1250.PubMedCrossRef
70.
71.
Pratchayasakul W, Arunsak B, Suparan K, Sriwichaiin S, Chunchai T, Chattipakorn N, et al. Combined caloric restriction and exercise provides greater metabolic and neurocognitive benefits than either as a monotherapy in obesity with or without estrogen deprivation. J Nutr Biochem. 2022;110: 109125.PubMedCrossRef
72.
Kishi T. Exercise training plus calorie restriction causes synergistic protection against cognitive decline via up-regulation of BDNF in hippocampus of stroke-prone hypertensive rats. Annu Int Conf IEEE Eng Med Biol Soc. 2012;2012:6764–7.
73.
Stranahan AM, Lee K, Martin B, Maudsley S, Golden E, Cutler RG, et al. Voluntary exercise and caloric restriction enhance hippocampal dendritic spine density and BDNF levels in diabetic mice. Hippocampus. 2009;19:951–61.PubMedPubMedCentralCrossRef
74.
Tay J, Zajac IT, Thompson CH, Luscombe-Marsh ND, Danthiir V, Noakes M, et al. A randomised-controlled trial of the effects of very low-carbohydrate and high-carbohydrate diets on cognitive performance in patients with type 2 diabetes. Br J Nutr. 2016;116:1745–53.CrossRef
75.
76.
Pelc MA. The effects of intermittent fasting and a low-carbohydrate diet on type 2 diabetes. JAAPA. 2023;36:26–9.PubMedCrossRef
77.
Trepanowski JF, Kroeger CM, Barnosky A, Klempel MC, Bhutani S, Hoddy KK, et al. Effect of Alternate-Day Fasting on Weight Loss, Weight Maintenance, and Cardioprotection Among Metabolically Healthy Obese Adults: A Randomized Clinical Trial. JAMA Intern Med. 2017;177:930.PubMedPubMedCentralCrossRef
78.
Mattson MP, Moehl K, Ghena N, Schmaedick M, Cheng A. Intermittent metabolic switching, neuroplasticity and brain health. Nat Rev Neurosci. 2018;19:81–94.CrossRef
79.
Hwang DS, Kwak HB, Ko IG, Kim SE, Jin JJ, Ji ES, et al. Treadmill Exercise Improves Memory Function Depending on Circadian Rhythm Changes in Mice. Int Neurourol J. 2016;20:S141-149.PubMedPubMedCentralCrossRef
80.
George & Anne Ryan Institute for Neuroscience, University of Rhode Island, 130 Flagg Road, Kingston, RI, 02881, US, Francis N, Department of Psychology, Stony Brook University, 100 Nicolls Rd, Stony Brook, NY, 11794, US. Intermittent Fasting and Brain Health: Efficacy and Potential Mechanisms of Action. OBM Geriatrics. 2020;4:1–19.
Metadaten
Titel
Effects of Caloric Restriction and Intermittent Fasting and Their Combined Exercise on Cognitive Functioning: A Review
verfasst von
Junming Wang
Yifeng Rang
Chunhong Liu
Publikationsdatum
06.09.2024
Verlag
Springer US
Erschienen in
Current Nutrition Reports / Ausgabe 4/2024
Elektronische ISSN: 2161-3311
DOI
https://doi.org/10.1007/s13668-024-00570-8

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