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Inflammation

Erschienen in:

01.12.2007

Effects of Enalaprilat on Acute Necrotizing Pancreatitis in Rats

verfasst von: Serdar Turkyilmaz, Etem Alhan, Cengiz Ercin, Birgul Kural Vanizor

Erschienen in: Inflammation | Ausgabe 6/2007

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Abstract

The aim of this study was to investigate the influence of enalaprilat on acute necrotizing pancreatitis (ANP) induced by glycodeoxycholic acid in rats. The induction of ANP resulted in a significant increase in the mortality rate, pancreatic necrosis, serum activity of amylase, alanine aminotransferase (ALT), and interleukin-6 (IL-6), lactate dehydrogenase (LDH) in bronchoalveolar lavage (BAL) fluid, serum concentration of urea, and tissue activity of myeloperoxidase (MPO) and maondialdehyde (MDA) in the pancreas and lung, and a significant decrease in concentrations of calcium, blood pressure, urine output and p0₂. The use of enalaprilat inhibited the changes in urine output, blood pressure, serum concentration of urea, p0₂, and tissue activity of MPO and MDA in the pancreas and lungs. It reduced the mortality and pancreatic damage. Enalaprilat demonstrated a beneficial effect on the course of ANP in rats; therefore, it may be used in the treatment of acute pancreatitis.

Schwarz, M., J. Thomson, H. Meyer, M. W. Büchler, and H. G. Beger. 2000. Frequency and time course of pancreatic and extra pancreatic bacterial infection in experimental pancreatitis in rats. Surgery 127:427–432.PubMedCrossRef

Saluja, A. K., and M. L. Steer. 1999. Pathophysiology of pancreatitis. Role of cytokines and inflammatory mediators. Digestion 60(Suppl 1):27–33.PubMedCrossRef

Klar, E., K. Messmer, A. L. Warshaw, and Herfarth C. 1990. Pancreatic ischemia in experimental acute pancreatitis: mechanism, significance and therapy. Br. J. Surg. 77:1205–1210.PubMedCrossRef

Alhan, E., U. Kücüktülü, C. Ercin, O. Deger, and R. Cicek. 2001. The effects of dopexamine on acute necrotizing pancreatitis in rats. Eur. J. Surg. 167:761–766.PubMedCrossRef

Norman J. 1998. The role of cytokines in the pathogenesis of acute pancreatitis. Am. J. Surg. 1175:76–83.CrossRef

Alhan, E., N. I. Kalyoncu, B. Vanizor, and C. Erçin. 2004. Effects of melatonin on acute pancreatitis in rats. Z. Gastroenterol. 42:967–972.PubMedCrossRef

Beger, H. G., R. Bittner, and M. Büchler. 1986. Hemodynamic data pattern in patients with acute pancreatitis. Gastroenterology 90:74–79.PubMed

Reid, I. A., B. J. Morris, W. F. Ganong. 1978. The renin–angiotensin system. Ann. Rev. Physiol. 40:377–410.CrossRef

Leung, P. S. 2003. Pancreatic renin–angiotensin system: a novel target for the potential treatment of pancreatic disease. J. Pancreas 4:89–91.

10.

Leung, P. S. 2002. Intrinsic angiotensin-generating system: its tissue specific functions and clinical implications. Panminerva. Med. 44:93–97.PubMed

11.

Leung, P. S, and M. C. Chappell. 2001. Tissue renin angiotensin system: its expression, localization, regulation and potential role in the pancreas. J. Mol. Endocrinol. 26:155–164.PubMedCrossRef

12.

Leung, P. S., W. P. Chan, and R. Nobiling. 2000. Regulated expression of pancreatic renin–angiotensin system in experimental pancreatitis. Mol. Cell Endocrinol. 166:121–128.PubMedCrossRef

13.

Schmidt, J., M. D. Rattner, and K. Lewandrowski. 1992. A better model of acute pancreatitis for evaluating therapy. Ann. Surg. 215:44–56.PubMedCrossRef

14.

Sookhal, S., J. J. Wang, M. McCourt, W. Kwan, D. H. Bouchier, and P. Redmond. 2002. A novel therapeutic strategy for attenuating neutrophil-mediated lung injury in vivo. Ann. Surg. 235:283–291.

15.

Lankisch, P. G., U. Pohl, J. Otto, and G. Rahlf. 1988. When should treatment of acute experimental pancreatitis be started? The early phase of bile-induced acute pancreatitis. Res. Exp. Med. 188:123–129.CrossRef

16.

Schierwagen, C., A. C. Bylund-Fellenius, and C. Lundberg. 1990. Improved method for quantification of tissue PMN accumulation measured by myeleperoxidase. J. Pharmacol. Meths. 23:179–186.CrossRef

17.

Lowry, O. H., N. L. Roseburgh, and A. L. Farr. 1951. Protein measurement with folin phenol reagent. J. Biol. Chem. 193:265–275.PubMed

18.

Buege, T. A., and S. D. Aust. 1978. Microsomal lipide peroxidation. Meth. Enzymol. 52:302–310.PubMedCrossRef

19.

Banks, P. A., S. Tenner, E. C. Noordhoek, G. Sica, S. Feng, and M. Zinner. 1996. Does pancreatic necrosis predict severity in patients with acute necrotizing pancreatitis? Digestion 57:218–223.

20.

Rau, B., B. Poch, F. Gansauge, A. Bauer, K. A. Nüssler, T. Nevalainen, M. H. Schoenberg, and H. G. Beger. 2000. Pathophysiologic role of oxygen free radicals in acute pancreatitis. Ann. Surg. 31:352–360.CrossRef

21.

Ip, S. P., P. C. Kwan, C. H. Williams, S. Pang, N. M. Hooper, and P. S. Leung. 2003. Changes of angiotensin-converting enzyme activity in the pancreas of chronic hypoxia and acute pancreatitis. Int. J. Biochem. Cell Biol. 35:944–954.PubMedCrossRef

22.

Tsang, S. W., S. P. Ip, T. P. Wong, C. T. Che, and P. S. Leung. 2003. Differential effects of saralasin and ramiprilat, the inhibitors of renin–angiotensin system, on cerulein-induced acute pancreatitis. Regul. Pept. 111:47–53.PubMedCrossRef

23.

Murakami, H., A. Nakao, W. Kishimoto, M. Nakano, and H. Takagel. 1995. Detection of \({\text{O}}^{ - }_{2} \) generation and neutrophil accumulation in rat lungs after acute necrotizing pancreatitis. Surgery 118:547–554.PubMedCrossRef

24.

Pupilli, C., L. Lasagni, P. Romagnani, F. Bellini, M. Mannelli, N. Misciglia, C. Mavilia, U. Vellei, D. Villari, and M. Serio. 1999. Angiotensin II stimulates the synthesis and secretion of vascular permeability factor/vascular endothelial growth factor in human mesangial cells. J. Am. Soc. Nephrol. 10:245–255.PubMedCrossRef

25.

Williams, B., A. Q. Baker, B. Gallacher, and D. Lodwick. 1995. Angiotensin II increases vascular permeability factor gene expression by human vascular smooth muscle cells. Hypertension 25:913–917.PubMed

26.

Marshall, R. P., P. Gohlke, R. C. Chambers, D. C. Howell, S. E. Bottoms, T. Unger, R. J. McAnulty, and G. J. Lauren. 2004. Angiotensin II and fibroproliferative response to acute lung injury. Am. J. Physiol. Lung Cell Mol. Physiol. 286:156–164.CrossRef

27.

Weidenhach, H., M. M. Lerch, T. M. Gress, D. Pfaff, S. Turi, and G. Adler. 1995. Vasoactive mediators and the progression from edematous to necrotizing experimental acute pancreatitis. Gut 37:434–440.CrossRef

28.

Mezzano, S., A. Droguett, M. E. Burgos, L. G. Ardiles, C. A. Flores, C. A. Aros, I. Caorsi, C. P. Vio, M. Ruiz-Ortega, and J. Egido. 2003. Renin–angiotensin system activation and interstitial inflammation in human diabetic nephropathy. Kidney Int. Suppl. 86:64–70.CrossRef

29.

Brewster, U. C., and M. A. Perazella. 2004. The renin–angiotensin–aldosterone system and the kidney: effects on kidney disease. Am. J. Med. 116:263–272.PubMedCrossRef

30.

Johnson, D. W., H. J. Saunders, D. A. Vesey, W. Qi, M. J. Field, and C. A. Pollock. 2000. Enalaprilat directly ameliorates in vitro cyclosporine nephrotoxicity in human tubulo–interstitial cells. Nephron 86:473–481.PubMedCrossRef

31.

Ohishi, T., H. Saito, K. Tsusaka, K. Toda, H. Inagaki, Y. Hamada, N. Kumagai, K. Atsukawa, and H. Ishii. 2001. Anti-fibrogenic effect of an angiotensin converting enzyme inhibitor on chronic carbon tetrachloride-induced hepatic fibrosis in rats. Hepatol. Res. 21:147–158.PubMedCrossRef

32.

Patel, T. 2003. Aberrant local renin–angiotensin II responses in the pathogenesis of primary sclerosing cholangitis. Med. Hypotheses 61:64–67.PubMedCrossRef

33.

Tsang, S. W., C. H. K. Cheng, and P. S. Leung. 2004. The role of pancreatic renin–angiotensin system in acinar digestive enzyme secretion and in acute pancreatitis. Regul. Pept. 119:213–219.PubMedCrossRef

34.

Borgström, A., S. Appelros, C. A. Müller, W. Uhl, and M. Büchler. 2002. Role of activation peptides from pancreatic proenzymes in the diagnosis and prognosis of acute pancreatitis. Surgery 131:125–128.PubMedCrossRef

Titel: Effects of Enalaprilat on Acute Necrotizing Pancreatitis in Rats
verfasst von: Serdar Turkyilmaz
Etem Alhan
Cengiz Ercin
Birgul Kural Vanizor
Publikationsdatum: 01.12.2007
Verlag: Springer US
Erschienen in: Inflammation / Ausgabe 6/2007
Print ISSN: 0360-3997
Elektronische ISSN: 1573-2576
DOI: https://doi.org/10.1007/s10753-007-9038-y

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Effects of Enalaprilat on Acute Necrotizing Pancreatitis in Rats

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